{"id":426650,"date":"2022-05-24T13:33:46","date_gmt":"2022-05-24T10:33:46","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=426650"},"modified":"2022-05-31T09:37:49","modified_gmt":"2022-05-31T06:37:49","slug":"autisme-schizophrenie-et-alzheimer-des-resultats-encourageants-pour-un-futur-traitement-en-israel","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/autisme-schizophrenie-et-alzheimer-des-resultats-encourageants-pour-un-futur-traitement-en-israel\/","title":{"rendered":"Autisme, schizophr\u00e9nie et alzheimer: des r\u00e9sultats encourageants pour un futur traitement en Isra\u00ebl!"},"content":{"rendered":"

Des r\u00e9sultats encourageants pourraient conduire \u00e0 des traitements efficaces pour une gamme de syndromes rares qui alt\u00e8rent les fonctions c\u00e9r\u00e9brales.<\/strong><\/em><\/p>\n

Par TPS<\/em><\/p>\n

Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert un m\u00e9canisme partag\u00e9 par des mutations dans deux g\u00e8nes sp\u00e9cifiques qui causent l’autisme, la schizophr\u00e9nie et d’autres conditions. Ils ont \u00e9galement d\u00e9couvert qu’un m\u00e9dicament exp\u00e9rimental est efficace dans les mod\u00e8les de laboratoire pour ces mutations et peut convenir au traitement d’une gamme de syndromes rares qui alt\u00e8rent les fonctions c\u00e9r\u00e9brales.<\/p>\n

Selon les chercheurs, les r\u00e9sultats encourageants pourraient conduire \u00e0 des traitements efficaces pour une gamme de syndromes rares qui alt\u00e8rent les fonctions c\u00e9r\u00e9brales et provoquent l’autisme, la schizophr\u00e9nie et des maladies neurod\u00e9g\u00e9n\u00e9ratives comme la maladie d’Alzheimer.<\/p>\n

La professeure Illana Gozes, directrice de recherche du D\u00e9partement de g\u00e9n\u00e9tique mol\u00e9culaire humaine et de biochimie de la Facult\u00e9 de m\u00e9decine Sackler et de la Sagol School of Neuroscience, a expliqu\u00e9 que certains cas d’autisme \u00e9taient caus\u00e9s par des mutations dans divers g\u00e8nes.<\/p>\n

\u00ab\u00a0Nous connaissons aujourd’hui plus de 100 syndromes g\u00e9n\u00e9tiques associ\u00e9s \u00e0 l’autisme, dont 10 sont consid\u00e9r\u00e9s comme relativement courants. Dans notre laboratoire, nous nous concentrons principalement sur l’un d’entre eux, le syndrome ADNP, caus\u00e9 par des mutations du g\u00e8ne ADNP, qui perturbent la fonction de la prot\u00e9ine ADNP, entra\u00eenant des d\u00e9fauts structurels dans le squelette des neurones du cerveau<\/em> \u00bb, a-t-elle d\u00e9clar\u00e9.<\/p>\n

\u00ab\u00a0Dans l’\u00e9tude actuelle, nous avons identifi\u00e9 un m\u00e9canisme sp\u00e9cifique qui provoque ces dommages dans les mutations de deux g\u00e8nes diff\u00e9rents\u00a0: ADNP et SHANK3 – un g\u00e8ne associ\u00e9 \u00e0 l’autisme et \u00e0 la schizophr\u00e9nie. Selon les estimations, ces deux mutations sont responsables de milliers de cas d’autisme dans le monde<\/em> \u00bb, a-t-elle d\u00e9clar\u00e9.<\/p>\n

Les chercheurs ont obtenu des cellules de patients atteints du syndrome ADNP. Ils ont d\u00e9couvert que lorsque la prot\u00e9ine ADNP est d\u00e9fectueuse, des neurones au squelette d\u00e9fectueux se forment, alt\u00e9rant les fonctions c\u00e9r\u00e9brales.<\/p>\n

\u00ab Nous avons d\u00e9couvert que dans certaines mutations, une section ajout\u00e9e \u00e0 la prot\u00e9ine la prot\u00e8ge et r\u00e9duit les dommages en se connectant \u00e0 un site de contr\u00f4le du syst\u00e8me squelettique du neurone. Nous savons que ce m\u00eame site de contr\u00f4le se trouve sur SHANK3 – une prot\u00e9ine tr\u00e8s \u00e9tudi\u00e9e, avec des mutations associ\u00e9es \u00e0 l’autisme et \u00e0 la schizophr\u00e9nie. Nous avons conclu que la capacit\u00e9 de se lier \u00e0 SHANK3 et \u00e0 d’autres prot\u00e9ines similaires offre une certaine protection contre les effets n\u00e9fastes de la mutation<\/em> \u00bb, a expliqu\u00e9 Gozes.<\/p>\n

\u00c0 l’\u00e9tape suivante de l’\u00e9tude, les chercheurs ont trouv\u00e9 des sites suppl\u00e9mentaires sur la prot\u00e9ine ADNP qui peuvent se lier \u00e0 SHANK3 et \u00e0 des prot\u00e9ines similaires. L’un de ces sites est situ\u00e9 sur NAP, une section de l’ADNP qui a \u00e9t\u00e9 d\u00e9velopp\u00e9e en un m\u00e9dicament exp\u00e9rimental, nomm\u00e9 Davunetide, par le laboratoire du professeur Gozes.<\/p>\n

Davunetide a \u00e9t\u00e9 reconnu par la FDA comme un m\u00e9dicament p\u00e9diatrique orphelin et rare pour le traitement futur du syndrome de d\u00e9veloppement ADNP et est prot\u00e9g\u00e9 par des brevets par l’interm\u00e9diaire de Ramot, la soci\u00e9t\u00e9 de transfert de technologie de l’Universit\u00e9 de Tel Aviv et sous licence exclusive \u00e0 ATED Therapeutics Ltd.<\/p>\n

Les chercheurs ont r\u00e9ussi \u00e0 d\u00e9montrer qu’un traitement prolong\u00e9 avec Davunetide am\u00e9liorait consid\u00e9rablement le comportement d’animaux mod\u00e8les atteints d’autisme caus\u00e9 par SHANK3.<\/p>\n

Gozes a not\u00e9 \u00ab dans des \u00e9tudes pr\u00e9c\u00e9dentes, nous avons montr\u00e9 que Davunetide est efficace pour traiter les mod\u00e8les de syndrome ADNP. La nouvelle \u00e9tude nous a amen\u00e9s \u00e0 croire qu’il pourrait \u00e9galement \u00eatre efficace dans le cas du syndrome de Phelan McDermid, caus\u00e9 par une mutation de SHANK3, ainsi que d’autres syndromes qui provoquent l’autisme par le m\u00eame m\u00e9canisme.<\/em>\u00ab\u00a0<\/p>\n

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Des r\u00e9sultats encourageants pourraient conduire \u00e0 des traitements efficaces pour une gamme de syndromes rares qui alt\u00e8rent les fonctions c\u00e9r\u00e9brales. Par TPS Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert un m\u00e9canisme partag\u00e9 par des mutations dans deux g\u00e8nes sp\u00e9cifiques qui causent l’autisme, la schizophr\u00e9nie et d’autres conditions. Ils ont \u00e9galement d\u00e9couvert qu’un m\u00e9dicament… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":378889,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[34843,36793,29798,29313,29783,43973],"class_list":["post-426650","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-alzheimer-fr","tag-autisme","tag-medecine","tag-recherche","tag-sante","tag-schizophrenie"],"better_featured_image":{"id":378889,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1362,"file":"2021\/02\/shutterstock_408591208-scaled.jpg","sizes":{"medium":{"file":"shutterstock_408591208-300x160.jpg","width":300,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-300x160.jpg"},"large":{"file":"shutterstock_408591208-1024x545.jpg","width":1024,"height":545,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1024x545.jpg"},"thumbnail":{"file":"shutterstock_408591208-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-150x150.jpg"},"medium_large":{"file":"shutterstock_408591208-768x409.jpg","width":768,"height":409,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-768x409.jpg"},"1536x1536":{"file":"shutterstock_408591208-1536x817.jpg","width":1536,"height":817,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1536x817.jpg"},"uwi-full-width":{"file":"shutterstock_408591208-780x415.jpg","width":780,"height":415,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-780x415.jpg"},"uwi-featured-carousel":{"file":"shutterstock_408591208-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_408591208-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_408591208-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_408591208-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_408591208-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_408591208-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-250x170.jpg"},"uwi-email":{"file":"shutterstock_408591208-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_408591208-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_408591208-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_408591208-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_408591208-2048x1536.jpg","width":2048,"height":1536,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-2048x1536.jpg"},"uwi-full-width-video":{"file":"shutterstock_408591208-779x414.jpg","width":779,"height":414,"mime-type":"image\/jpeg","source_u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