{"id":416235,"date":"2022-02-14T11:22:13","date_gmt":"2022-02-14T08:22:13","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=416235"},"modified":"2022-02-14T18:35:56","modified_gmt":"2022-02-14T15:35:56","slug":"des-chercheurs-israeliens-decouvrent-des-indices-precoces-de-la-maladie-dalzheimer","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/des-chercheurs-israeliens-decouvrent-des-indices-precoces-de-la-maladie-dalzheimer\/","title":{"rendered":"Des chercheurs isra\u00e9liens d\u00e9couvrent des indices pr\u00e9coces de la maladie d’Alzheimer"},"content":{"rendered":"

La d\u00e9couverte d’une activit\u00e9 c\u00e9r\u00e9brale anormale peut permettre un diagnostic pr\u00e9coce de la maladie neurologique d\u00e9vastatrice.<\/strong><\/em><\/p>\n

Par Abigail Klein Leichman, Israel21c<\/em><\/p>\n

Une nouvelle \u00e9tude a r\u00e9v\u00e9l\u00e9 une activit\u00e9 c\u00e9r\u00e9brale pathologique qui pr\u00e9c\u00e8de de plusieurs ann\u00e9es les sympt\u00f4mes de la maladie d’Alzheimer : une activit\u00e9 accrue de l’hippocampe pendant l’anesth\u00e9sie et le sommeil, r\u00e9sultant d’une d\u00e9faillance du m\u00e9canisme qui stabilise le r\u00e9seau neuronal.<\/p>\n

La d\u00e9couverte de cette activit\u00e9 anormale peut permettre un diagnostic pr\u00e9coce de la maladie neurologique d\u00e9vastatrice.<\/p>\n

La chercheuse principale\u00a0Prof. Inna Slutsky\u00a0de l’Universit\u00e9 de Tel-Aviv a expliqu\u00e9 que les d\u00e9p\u00f4ts amylo\u00efdes, une caract\u00e9ristique de la pathologie de la maladie d’Alzheimer, se forment dans le cerveau des patients d\u00e8s 10 ou 20\u00a0ans avant l’apparition des sympt\u00f4mes typiques tels que les troubles de la m\u00e9moire et le d\u00e9clin cognitif.<\/p>\n

\u00ab\u00a0Nous pensons que l’identification d’une signature d’activit\u00e9 c\u00e9r\u00e9brale aberrante au stade pr\u00e9-symptomatique de la maladie d’Alzheimer et la compr\u00e9hension des m\u00e9canismes sous-jacents \u00e0 son d\u00e9veloppement sont la cl\u00e9 d’un traitement efficace<\/em>\u00ab\u00a0, a-t-elle d\u00e9clar\u00e9.<\/p>\n

Les chercheurs ont \u00e9tudi\u00e9 la r\u00e9gion hippocampique du cerveau dans des mod\u00e8les animaux de la maladie d’Alzheimer, mesurant l’activit\u00e9 cellulaire dans l’hippocampe lorsque les animaux \u00e9taient \u00e9veill\u00e9s et actifs, et lorsqu’ils \u00e9taient endormis ou anesth\u00e9si\u00e9s.<\/p>\n

M\u00eame s’il est connu que l’activit\u00e9 neuronale de l’hippocampe diminue chez les animaux sains endormis anesth\u00e9si\u00e9s, l’activit\u00e9 de l’hippocampe reste \u00e9lev\u00e9e chez les animaux atteints de la maladie d’Alzheimer.<\/p>\n

\u00ab\u00a0Cela est d\u00fb \u00e0 une d\u00e9faillance de la r\u00e9gulation physiologique, jamais observ\u00e9e auparavant dans le contexte de la maladie d’Alzheimer<\/em>\u00ab\u00a0, a d\u00e9clar\u00e9 l’\u00e9tudiant doctorant Daniel Zarhin.<\/p>\n

Cette activit\u00e9 anormale s’est av\u00e9r\u00e9e beaucoup plus fr\u00e9quente sous anesth\u00e9sie. Par cons\u00e9quent, dit Slutsky, \u00ab\u00a0il serait important de tester si une anesth\u00e9sie courte peut \u00eatre utilis\u00e9e pour le diagnostic pr\u00e9coce de la maladie d’Alzheimer<\/em>\u00ab\u00a0.<\/p>\n

Halit Baeloha, qui \u00e9tudie les probl\u00e8mes de sommeil li\u00e9s \u00e0 la maladie d’Alzheimer, a d\u00e9clar\u00e9 que la perturbation d\u00e9couverte commen\u00e7ait avant l’apparition des troubles du sommeil typiques observ\u00e9s chez les patients atteints de la maladie d’Alzheimer.<\/p>\n

Existe-t-il un m\u00e9dicament qui pourrait corriger le m\u00e9canisme de r\u00e9gulation alt\u00e9r\u00e9 ? Les chercheurs ont essay\u00e9 un m\u00e9dicament existant pour la scl\u00e9rose en plaques, souvent utilis\u00e9 pour aider \u00e0 r\u00e9guler l’activit\u00e9 neuronale chez les patients \u00e9pileptiques. En effet, ce m\u00e9dicament a stabilis\u00e9 l’activit\u00e9 et r\u00e9duit l’activit\u00e9 pathologique dans le mod\u00e8le Alzheimer pendant l’anesth\u00e9sie.<\/p>\n

L’\u00e9tude\u00a0a \u00e9t\u00e9 publi\u00e9e\u00a0dans la revue scientifique\u00a0Cell\u00a0Reports.<\/p>\n

Slutsky a d\u00e9clar\u00e9 que des projections r\u00e9centes montraient que le nombre de personnes atteintes de d\u00e9mence dans le monde passerait de 50 millions en 2019 \u00e0 plus de 150 millions en 2050.<\/p>\n

\u00ab Cette \u00e9norme augmentation de la pr\u00e9valence de la maladie d’Alzheimer due \u00e0 l’augmentation attendue de la croissance d\u00e9mographique et de l’esp\u00e9rance de vie se poursuivra \u00e0 moins que nous ne d\u00e9veloppions des traitements efficaces. Il s’agit clairement d’une alerte pour investir dans la recherche sur la d\u00e9mence et sa forme la plus fr\u00e9quente – la maladie d’Alzheimer<\/em> \u00bb, a-t-elle d\u00e9clar\u00e9.<\/p>\n

Les chercheurs pr\u00e9voient \u00e0 pr\u00e9sent de collaborer avec des centres m\u00e9dicaux en Isra\u00ebl et dans le monde pour tester si les m\u00e9canismes d\u00e9couverts dans des mod\u00e8les animaux pouvaient \u00e9galement \u00eatre identifi\u00e9s chez des patients atteints de la maladie d’Alzheimer \u00e0 un stade pr\u00e9coce.<\/p>\n

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La d\u00e9couverte d’une activit\u00e9 c\u00e9r\u00e9brale anormale peut permettre un diagnostic pr\u00e9coce de la maladie neurologique d\u00e9vastatrice. Par Abigail Klein Leichman, Israel21c Une nouvelle \u00e9tude a r\u00e9v\u00e9l\u00e9 une activit\u00e9 c\u00e9r\u00e9brale pathologique qui pr\u00e9c\u00e8de de plusieurs ann\u00e9es les sympt\u00f4mes de la maladie d’Alzheimer : une activit\u00e9 accrue de l’hippocampe pendant l’anesth\u00e9sie et le sommeil, r\u00e9sultant d’une d\u00e9faillance… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":364656,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[34843,29951,29306,29798,29313,29783],"class_list":["post-416235","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-alzheimer-fr","tag-cerveau","tag-maladie","tag-medecine","tag-recherche","tag-sante"],"better_featured_image":{"id":364656,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1786,"file":"2020\/09\/shutterstock_1176078337-scaled.jpg","sizes":{"medium":{"file":"shutterstock_1176078337-300x209.jpg","width":300,"height":209,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-300x209.jpg"},"large":{"file":"shutterstock_1176078337-1024x714.jpg","width":1024,"height":714,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-1024x714.jpg"},"thumbnail":{"file":"shutterstock_1176078337-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-150x150.jpg"},"medium_large":{"file":"shutterstock_1176078337-768x536.jpg","width":768,"height":536,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-768x536.jpg"},"1536x1536":{"file":"shutterstock_1176078337-1536x1071.jpg","width":1536,"height":1071,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-1536x1071.jpg"},"2048x2048":{"file":"shutterstock_1176078337-2048x1428.jpg","width":2048,"height":1428,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-2048x1428.jpg"},"uwi-full-width":{"file":"shutterstock_1176078337-746x520.jpg","width":746,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-746x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1176078337-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1176078337-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1176078337-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1176078337-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1176078337-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1176078337-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-250x170.jpg"},"uwi-email":{"file":"shutterstock_1176078337-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1176078337-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_1176078337-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_1176078337-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/09\/shutterstock_1176078337-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_1176078337-2048x1536.jpg","width":2048,"height":1536,"mime-typ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