{"id":413941,"date":"2022-01-24T12:45:28","date_gmt":"2022-01-24T09:45:28","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=413941"},"modified":"2022-01-24T16:46:14","modified_gmt":"2022-01-24T13:46:14","slug":"des-chercheurs-israeliens-sur-le-point-de-trouver-comment-freiner-la-progression-du-cancer-du-pancreas","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/des-chercheurs-israeliens-sur-le-point-de-trouver-comment-freiner-la-progression-du-cancer-du-pancreas\/","title":{"rendered":"Des chercheurs isra\u00e9liens sur le point de trouver comment freiner la progression du cancer du pancr\u00e9as"},"content":{"rendered":"

L’\u00e9tude \u00ab\u00a0r\u00e9v\u00e8le le talon d’Achille de la cellule canc\u00e9reuse\u00a0\u00bb, a d\u00e9clar\u00e9 le professeur Ido Wolf, Directeur du service d’oncologie au Sourasky Medical Center.<\/strong><\/em><\/p>\n

Par Maayan Hoffman, JNS.org<\/em><\/p>\n

Une \u00e9quipe de chercheurs du Tel Aviv Sourasky Medical Center a d\u00e9couvert comment les cellules canc\u00e9reuses du pancr\u00e9as se propagent dans le foie, ce qui pourrait \u00eatre la cl\u00e9 du d\u00e9veloppement de traitements pour le ralentir et prolonger la vie des patients.<\/p>\n

L’\u00e9tude, dirig\u00e9e par le Dr Tami Rubinek, chef du laboratoire de recherche en oncologie de l’h\u00f4pital, en collaboration avec Ph.D. l’\u00e9tudiante Shani Journo, sous les auspices du Professeur Ido Wolf, a permis de d\u00e9couvrir qu’une mutation provoquant la disparition des prot\u00e9ines \u00ab\u00a0p15\u00a0\u00bb et \u00ab\u00a0p16\u00a0\u00bb apparaissait davantage dans les m\u00e9tastases h\u00e9patiques et moins dans les tumeurs canc\u00e9reuses du pancr\u00e9as au niveau du pancr\u00e9as ou d’autres zones du corps, comme les poumons ou l’abdomen.<\/p>\n

Les chercheurs ont pu montrer que lorsque ces prot\u00e9ines disparaissaient, la cellule canc\u00e9reuse modifiait ses propri\u00e9t\u00e9s et son activit\u00e9 m\u00e9tabolique d’une mani\u00e8re qui facilite sa croissance dans l’environnement unique du foie.<\/p>\n

Le foie est souvent \u00abl’organe tueur\u00bb, a d\u00e9clar\u00e9 Wolf \u00e0 JNS, ce qui signifie que les patients meurent souvent lorsque le cancer du pancr\u00e9as se propage jusqu’\u00e0 leur foie.<\/p>\n

En g\u00e9n\u00e9ral, le cancer du pancr\u00e9as est l’un des cancers les plus meurtriers. Wolf a d\u00e9clar\u00e9 qu’une fois que le cancer commen\u00e7ait \u00e0 se propager, les patients ne vivaient g\u00e9n\u00e9ralement qu’entre six mois et un an.<\/p>\n

Entre 800 et 900 cas de cancer du pancr\u00e9as sont diagnostiqu\u00e9s en Isra\u00ebl chaque ann\u00e9e, selon le site Internet du minist\u00e8re de la Sant\u00e9. Aux \u00c9tats-Unis, environ 60 000 nouveaux cas sont diagnostiqu\u00e9s. Et, a d\u00e9clar\u00e9 Wolf, les chiffres augmentent r\u00e9guli\u00e8rement.<\/p>\n

Selon lui, la prochaine \u00e9tape serait de trouver des traitements bas\u00e9s sur les r\u00e9sultats de l’\u00e9tude.<\/p>\n

Wolf a averti qu’il \u00e9tait peu probable que l’information conduise \u00e0 un rem\u00e8de contre le cancer. Cependant, il a d\u00e9clar\u00e9 que cela conduirait probablement \u00e0 des traitements qui pourraient prolonger la vie des patients.<\/p>\n

Jusqu’\u00e0 cette \u00e9tude, la plus vaste du genre, incluant 17 000 patients atteints d’un cancer du pancr\u00e9as \u00e0 travers monde entier, dont les informations \u00e9taient saisies dans une base de donn\u00e9es de FoundationOne, l’une des plus grandes soci\u00e9t\u00e9s de g\u00e9nomique du cancer au monde, on supposait que tous les cancers du pancr\u00e9as \u00e9taient similaires, niant l’existence de sous-groupes.<\/p>\n

\u00ab\u00a0L’\u00e9tude \u2026 r\u00e9v\u00e8le le talon d’Achille de la cellule canc\u00e9reus<\/em>e\u00a0\u00bb, a d\u00e9clar\u00e9 Wolf.<\/p>\n

Le Dr Ayelet Erez de l’Institut Weizmann des sciences, un expert de la dynamique du m\u00e9tabolisme cellulaire qui n’est pas li\u00e9 \u00e0 la recherche de Tel-Aviv, a confirm\u00e9 la nouveaut\u00e9 de l’\u00e9tude et ses implications potentielles.<\/p>\n

\u00ab\u00a0La nouveaut\u00e9 de l’article est de promouvoir le concept selon lequel le paysage m\u00e9tabolique de l’organe distant affecte le tropisme des m\u00e9tastases des cancers primaires<\/em>\u00ab\u00a0, a-t-elle d\u00e9clar\u00e9 \u00e0 JNS. \u00ab\u00a0Les r\u00e9sultats de ce travail ont des implications translationnelles car ils exposent les vuln\u00e9rabilit\u00e9s m\u00e9taboliques des cellules m\u00e9tastasantes qui peuvent \u00eatre cibl\u00e9es pour la th\u00e9rapie.<\/em>\u00ab\u00a0<\/p>\n

Do You Love Israel? Make a Donation - Show Your Support!<\/h2>
\"\"<\/a>

<\/p><\/div>

Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p>

Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p>

Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. Help us fight back!<\/strong><\/a> <\/p>

STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode>

\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"

L’\u00e9tude \u00ab\u00a0r\u00e9v\u00e8le le talon d’Achille de la cellule canc\u00e9reuse\u00a0\u00bb, a d\u00e9clar\u00e9 le professeur Ido Wolf, Directeur du service d’oncologie au Sourasky Medical Center. Par Maayan Hoffman, JNS.org Une \u00e9quipe de chercheurs du Tel Aviv Sourasky Medical Center a d\u00e9couvert comment les cellules canc\u00e9reuses du pancr\u00e9as se propagent dans le foie, ce qui pourrait \u00eatre la… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":380477,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[33896,34248,29798,34490,29313,29783],"class_list":["post-413941","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-cancer-fr","tag-innovation-fr","tag-medecine","tag-pancreas-fr","tag-recherche","tag-sante"],"better_featured_image":{"id":380477,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1709,"file":"2021\/02\/shutterstock_751727689-scaled.jpg","sizes":{"medium":{"file":"shutterstock_751727689-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-300x200.jpg"},"large":{"file":"shutterstock_751727689-1024x683.jpg","width":1024,"height":683,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1024x683.jpg"},"thumbnail":{"file":"shutterstock_751727689-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-150x150.jpg"},"medium_large":{"file":"shutterstock_751727689-768x513.jpg","width":768,"height":513,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-768x513.jpg"},"1536x1536":{"file":"shutterstock_751727689-1536x1025.jpg","width":1536,"height":1025,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1536x1025.jpg"},"uwi-full-width":{"file":"shutterstock_751727689-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_751727689-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_751727689-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_751727689-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_751727689-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_751727689-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_751727689-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-250x170.jpg"},"uwi-email":{"file":"shutterstock_751727689-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_751727689-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_751727689-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_751727689-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1024x768.jpg"},"uwi-full-width-video":{"file":"shutterstock_751727689-779x519.jpg","width":779,"height":519,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-779x519.jpg"},"uwi-fb-share-video":{"file":"shutterstock_751727689-600x315.jpg","width":600,"height":315,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-600x315.jpg"},"uwi-fb-share":{"file":"shutterstock_751727689-600x320.jpg","width":600,"height":320,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-600x320.jpg"},"uwi-featured-content-video":{"file":"shutterstock_751727689-289x159.jpg","width":289,"height":159,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-289x159.jpg"},"uwi-content-loop-video":{"file":"shutterstock_751727689-189x189.jpg","width":189,"height":189,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-189x189.jpg"},"uwi-category_list-video":{"file":"shutterstock_751727689-179x99.jpg","width":179,"height":99,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-179x99.jpg"},"uwi-tiny-video":{"file":"shutterstock_751727689-39x39.jpg","width":39,"height":39,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-39x39.jpg"},"uwi-email-featured-video":{"file":"shutterstock_751727689-249x169.jpg","width":249,"height":169,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-249x169.jpg"},"uwi-email-video":{"file":"shutterstock_751727689-209x139.jpg","width":209,"height":139,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-209x139.jpg"},"uwi-iphone-video":{"file":"shutterstock_751727689-959x639.jpg","width":959,"height":639,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-959x639.jpg"},"uwi-iphone-x2-video":{"file":"shutterstock_751727689-1135x639.jpg","width":1135,"height":639,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1135x639.jpg"},"uwi-ipad-video":{"file":"shutterstock_751727689-1123x767.jpg","width":1123,"height":767,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1123x767.jpg"},"post-thumbnail":{"file":"shutterstock_751727689-125x125.jpg","width":125,"height":125,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-125x125.jpg"}},"image_meta":{"aperture":"0","credit":"Shutterstock","camera":"","caption":"","created_timestamp":"0","copyright":"Copyright (c) 2017 Shutterstock. No use without permission.","focal_length":"0","iso":"0","shutter_speed":"0","title":"Medical,Worker,In,Lab,Coat,And,Sterile,Mask,,Doing,A","orientation":"0","keywords":["handsome,biotechnology,medical,occupation,sterile masks,technici"]},"original_image":"shutterstock_751727689.jpg"},"post":380476,"source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-scaled.jpg"},"aioseo_notices":[],"distributor_meta":false,"distributor_terms":false,"distributor_media":false,"distributor_original_site_name":"Unis avec Isra\u00ebl","distributor_original_site_url":"https:\/\/kinsta.unitedwithisrael.org\/fr\/","push-errors":false,"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts\/413941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/users\/4242"}],"replies":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/comments?post=413941"}],"version-history":[{"count":0,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts\/413941\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/media\/380477"}],"wp:attachment":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/media?parent=413941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/categories?post=413941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/tags?post=413941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}