{"id":412670,"date":"2022-01-13T09:50:04","date_gmt":"2022-01-13T06:50:04","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=412670"},"modified":"2022-01-13T10:40:58","modified_gmt":"2022-01-13T07:40:58","slug":"les-chercheurs-israeliens-font-une-decouverte-susceptible-de-revolutionner-le-traitement-contre-le-cancer","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/les-chercheurs-israeliens-font-une-decouverte-susceptible-de-revolutionner-le-traitement-contre-le-cancer\/","title":{"rendered":"Les chercheurs isra\u00e9liens font une d\u00e9couverte susceptible de r\u00e9volutionner le traitement contre le cancer"},"content":{"rendered":"

Des scientifiques de l’Universit\u00e9 Ben Gourion du N\u00e9guev en Isra\u00ebl ont fait une d\u00e9couverte potentiellement r\u00e9volutionnaire sur le r\u00f4le biologique d’un peptide anticanc\u00e9reux en tant qu’inhibiteur de prot\u00e9ine kinase.<\/strong><\/em><\/p>\n

Source : Iton Gadol<\/em><\/p>\n

Les peptides sont de courtes cha\u00eenes d’acides amin\u00e9s li\u00e9s par des liaisons peptidiques. Les longues mol\u00e9cules constitu\u00e9es d’unit\u00e9s peptidiques sont ce que nous appelons des prot\u00e9ines, et les prot\u00e9ines kinases sont des enzymes qui peuvent modifier la fonction d’une prot\u00e9ine. La d\u00e9couverte des chercheurs, en se concentrant sur un peptide naturel dans la r\u00e9gion non codante de l’ARNm, pourrait grandement contribuer \u00e0 la fa\u00e7on de traiter le cancer \u00e0 l’avenir.<\/p>\n

L’ARNm, ou acide ribonucl\u00e9ique messager, remplit de nombreuses fonctions cl\u00e9s en biologie humaine, notamment le codage de prot\u00e9ines qui ont diff\u00e9rentes fonctions. Environ 40\u00a0% de l’ARNm d’une r\u00e9gion particuli\u00e8re contient des s\u00e9quences qui codent pour des peptides courts, bien que, jusqu’\u00e0 r\u00e9cemment, les scientifiques croyaient que la r\u00e9gion \u00e9tait ce qu’on appelle \u00ab\u00a0non codante\u00a0\u00bb et ne savaient pas si les peptides courts avaient une fonction.<\/p>\n

A travers leurs recherches, les scientifiques ont pu isoler et confirmer que l’un des courts peptides agit comme un inhibiteur de kinase, ce qui signifie qu’il inhibe la progression du cancer entre les stades de d\u00e9veloppement des cellules canc\u00e9reuses et la m\u00e9tastase. Les prot\u00e9ines envoient des signaux aux cellules qui leur donnent des instructions, et les chercheurs du BGU ont montr\u00e9 pour la premi\u00e8re fois que les inhibiteurs \u00e9taient capables de bloquer les messages de kinase qui indiquent aux cellules canc\u00e9reuses de se diviser.<\/p>\n

\u00ab D\u00e9montrer clairement le r\u00f4le de ce peptide n’est que la partie immerg\u00e9e de l’iceberg<\/em> \u00bb, a expliqu\u00e9 Etta Livneh, professeure et membre de la Facult\u00e9 des sciences de la sant\u00e9 de l’Universit\u00e9 Ben Gourion. \u00ab\u00a0Maintenant que nous savons qu’au moins certains peptides ont une fonction biologique, nous pouvons commencer \u00e0 d\u00e9couvrir les fonctions de bien d’autres.<\/em>\u00a0\u00bb<\/p>\n

Le professeur Livneh a collabor\u00e9 \u00e0 cette recherche avec les professeurs Esti Yeger-Lotem et Moshe Elkabets. Parmi les autres chercheurs figuraient Divya Ram Jayaram, Sigal Frost, Chanan Argov, Vijayasteltar Belsamma Liju, Nikhil Ponnoor Anto, Amitha Muraleedharan, Assaf Ben-Ari, Rose Sinay, Ilan Smoly, Ofra Novoplansky, Noah Isakov, Dr Debra Toiber et Chen Keasar.<\/em><\/p>\n

La recherche a \u00e9t\u00e9 soutenue par la Fondation isra\u00e9lienne pour la science (subvention n\u00b0 2368\/19).<\/em><\/p>\n

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Des scientifiques de l’Universit\u00e9 Ben Gourion du N\u00e9guev en Isra\u00ebl ont fait une d\u00e9couverte potentiellement r\u00e9volutionnaire sur le r\u00f4le biologique d’un peptide anticanc\u00e9reux en tant qu’inhibiteur de prot\u00e9ine kinase. Source : Iton Gadol Les peptides sont de courtes cha\u00eenes d’acides amin\u00e9s li\u00e9s par des liaisons peptidiques. Les longues mol\u00e9cules constitu\u00e9es d’unit\u00e9s peptidiques sont ce que… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":378889,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[33896,30152,29798,29313,29783,28846],"class_list":["post-412670","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-cancer-fr","tag-chercheurs","tag-medecine","tag-recherche","tag-sante","tag-traitement"],"better_featured_image":{"id":378889,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1362,"file":"2021\/02\/shutterstock_408591208-scaled.jpg","sizes":{"medium":{"file":"shutterstock_408591208-300x160.jpg","width":300,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-300x160.jpg"},"large":{"file":"shutterstock_408591208-1024x545.jpg","width":1024,"height":545,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1024x545.jpg"},"thumbnail":{"file":"shutterstock_408591208-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-150x150.jpg"},"medium_large":{"file":"shutterstock_408591208-768x409.jpg","width":768,"height":409,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-768x409.jpg"},"1536x1536":{"file":"shutterstock_408591208-1536x817.jpg","width":1536,"height":817,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1536x817.jpg"},"uwi-full-width":{"file":"shutterstock_408591208-780x415.jpg","width":780,"height":415,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-780x415.jpg"},"uwi-featured-carousel":{"file":"shutterstock_408591208-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_408591208-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_408591208-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_408591208-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_408591208-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_408591208-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-250x170.jpg"},"uwi-email":{"file":"shutterstock_408591208-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_408591208-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_408591208-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_408591208-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_408591208-2048x1536.jpg","width":2048,"height":1536,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_408591208-2048x1536.jpg"},"uwi-full-width-video":{"file":"shutterstock_408591208-779x414.jpg","width":779,"height":414,"mime-type":"image\/jpeg","source_url"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