{"id":412057,"date":"2022-01-06T10:41:58","date_gmt":"2022-01-06T07:41:58","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=412057"},"modified":"2022-01-09T13:17:59","modified_gmt":"2022-01-09T10:17:59","slug":"israel-met-au-point-une-nouvelle-therapie-pour-lutter-contre-la-nephrite-lupique","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/israel-met-au-point-une-nouvelle-therapie-pour-lutter-contre-la-nephrite-lupique\/","title":{"rendered":"Isra\u00ebl met au point une nouvelle th\u00e9rapie pour lutter contre la n\u00e9phrite lupique"},"content":{"rendered":"

Une nouvelle th\u00e9rapie cibl\u00e9e inhibe des cellules immunitaires sp\u00e9cifiques associ\u00e9es \u00e0 la n\u00e9phrite lupique, apportant de l’espoir aux personnes atteintes.<\/strong><\/em><\/p>\n

Par Pessa’h Benson, Unis avec Isra\u00ebl<\/em><\/p>\n

Des chercheurs isra\u00e9liens ont d\u00e9velopp\u00e9 un traitement r\u00e9volutionnaire qui pourrait aider les personnes souffrant de n\u00e9phrite lupique, un trouble dans lequel le syst\u00e8me immunitaire attaque les reins du corps.<\/p>\n

Selon la Lupus Foundation of America, au moins cinq millions de personnes dans le monde souffrent d’une forme de lupus, qui peut \u00e9galement attaquer le cerveau, les articulations et la peau. On estime que la moiti\u00e9 des personnes atteintes de lupus souffrent de n\u00e9phrite lupique.<\/p>\n

Les traitements disponibles peuvent traiter efficacement la n\u00e9phrite lupique. Cependant, toutes les personnes ne r\u00e9pondent pas bien au traitement car les m\u00e9dicaments impliqu\u00e9s suppriment le syst\u00e8me immunitaire, ce qui rend les patients tr\u00e8s sensibles aux infections. Un patient dont les reins atteignent un certain point de cicatrisation ou d’inflammation n\u00e9cessitera une dialyse ou une greffe de rein pour rester en vie. Le traitement est encore compliqu\u00e9 par le fait que d’autres organes sont attaqu\u00e9s.<\/p>\n

Une nouvelle th\u00e9rapie cibl\u00e9e, d\u00e9velopp\u00e9e par des chercheurs de la Facult\u00e9 de m\u00e9decine Azrieli de l’Universit\u00e9 Bar-Ilan, du Coll\u00e8ge de m\u00e9decine Albert Einstein, de l’Universit\u00e9 de Houston et de la soci\u00e9t\u00e9 pharmaceutique Equillium, ainsi que plusieurs autres collaborateurs universitaires, inhibe des cellules immunitaires sp\u00e9cifiques associ\u00e9e \u00e0 la n\u00e9phrite lupique.<\/p>\n

Cette th\u00e9rapie s’est av\u00e9r\u00e9e efficace pour am\u00e9liorer l’inflammation des reins dans des mod\u00e8les animaux de lupus et de n\u00e9phrite lupique. La nouvelle approche pourrait servir d’alternative aux traitements actuels ciblant plusieurs cellules immunitaires et fournir un rem\u00e8de plus efficace et potentiellement personnalis\u00e9 pour la n\u00e9phrite lupique. Le d\u00e9veloppement a \u00e9t\u00e9 rapport\u00e9 dans une \u00e9tude publi\u00e9e dans le Journal of Clinical Investigation.<\/p>\n

De nombreux types diff\u00e9rents de cellules immunitaires sont impliqu\u00e9s dans les m\u00e9canismes sous-jacents aux l\u00e9sions des organes cibles dans le lupus et d’autres maladies auto-immunes. Parmi ces types cellulaires importants se trouvent les cellules T, qui affectent le rein en interagissant et en se liant avec d’autres cellules, de la m\u00eame mani\u00e8re qu’une cl\u00e9 est ins\u00e9r\u00e9e dans une serrure. Les chercheurs ont d\u00e9couvert que les lymphocytes T exprimant une glycoprot\u00e9ine appel\u00e9e CD6 (le verrou) se lieraient \u00e0 une mol\u00e9cule connue sous le nom d’ALCAM qui s’affiche sur d’autres cellules (la cl\u00e9). Lorsque cette liaison \u00e9tait termin\u00e9e, les cellules T s’activaient, entra\u00eenant une inflammation des reins.<\/p>\n

Pour emp\u00eacher ce d\u00e9veloppement dommageable, les chercheurs ont d\u00e9velopp\u00e9 un anticorps qui a perturb\u00e9 le processus en bloquant l’interaction entre CD6 et ALCAM. De mani\u00e8re imag\u00e9e, cela reviendrait \u00e0 verser de la colle dans une serrure pour \u00e9viter qu’une cl\u00e9 ne la d\u00e9verrouille.<\/p>\n

Lorsque l’activation de la voie CD6\/ALCAM a \u00e9t\u00e9 bloqu\u00e9e dans des mod\u00e8les animaux, les chercheurs ont observ\u00e9 une am\u00e9lioration th\u00e9rapeutique significative de l’inflammation r\u00e9nale.<\/p>\n

\u00ab\u00a0Jusqu’\u00e0 pr\u00e9sent, les interactions CD6\/ALCAM n’\u00e9taient pas consid\u00e9r\u00e9es comme pertinentes ou instrumentales dans la n\u00e9phrite lupique<\/em>\u00ab\u00a0, d\u00e9clare le professeur Chaim Putterman, de la facult\u00e9 de m\u00e9decine Azrieli de l’Universit\u00e9 Bar-Ilan (Safed, Isra\u00ebl) et de l’\u00e9cole de m\u00e9decine Albert Einstein. (Bronx, NY), qui a dirig\u00e9 l’\u00e9tude avec les co-auteurs principaux, le Dr Cherie Ng et le Dr Chandra Mohan.<\/p>\n

\u00ab\u00a0L’intervention que nous d\u00e9crivons, qui cible les cellules T plut\u00f4t que plusieurs types de cellules immunitaires, peut potentiellement fournir aux m\u00e9decins un autre outil efficace pour le traitement d’une maladie difficile et stimulante.<\/em>\u00a0\u00bb<\/p>\n

Les sympt\u00f4mes de la n\u00e9phrite lupique comprennent la prise de poids, la fatigue, l’hypertension art\u00e9rielle, la fi\u00e8vre, une \u00e9ruption cutan\u00e9e rouge, des douleurs articulaires, des mictions fr\u00e9quentes, du sang dans les urines et un gonflement des jambes, des pieds, des chevilles, des articulations, des mains ou du visage.<\/p>\n

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Une nouvelle th\u00e9rapie cibl\u00e9e inhibe des cellules immunitaires sp\u00e9cifiques associ\u00e9es \u00e0 la n\u00e9phrite lupique, apportant de l’espoir aux personnes atteintes. Par Pessa’h Benson, Unis avec Isra\u00ebl Des chercheurs isra\u00e9liens ont d\u00e9velopp\u00e9 un traitement r\u00e9volutionnaire qui pourrait aider les personnes souffrant de n\u00e9phrite lupique, un trouble dans lequel le syst\u00e8me immunitaire attaque les reins du corps…. Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":380477,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[34248,29798,29313],"class_list":["post-412057","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-innovation-fr","tag-medecine","tag-recherche"],"better_featured_image":{"id":380477,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1709,"file":"2021\/02\/shutterstock_751727689-scaled.jpg","sizes":{"medium":{"file":"shutterstock_751727689-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-300x200.jpg"},"large":{"file":"shutterstock_751727689-1024x683.jpg","width":1024,"height":683,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1024x683.jpg"},"thumbnail":{"file":"shutterstock_751727689-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-150x150.jpg"},"medium_large":{"file":"shutterstock_751727689-768x513.jpg","width":768,"height":513,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-768x513.jpg"},"1536x1536":{"file":"shutterstock_751727689-1536x1025.jpg","width":1536,"height":1025,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1536x1025.jpg"},"uwi-full-width":{"file":"shutterstock_751727689-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_751727689-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_751727689-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_751727689-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_751727689-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_751727689-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_751727689-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-250x170.jpg"},"uwi-email":{"file":"shutterstock_751727689-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_751727689-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_751727689-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_751727689-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-1024x768.jpg"},"uwi-full-width-video":{"file":"shutterstock_751727689-779x519.jpg","width":779,"height":519,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/02\/shutterstock_751727689-779x519.jpg"},"uwi-fb-share-video":{"file":"shutterstock_751727689-600x315.jpg","width":600,"height":315,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/u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