{"id":406281,"date":"2021-11-15T12:16:11","date_gmt":"2021-11-15T09:16:11","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=406281"},"modified":"2021-11-15T16:06:39","modified_gmt":"2021-11-15T13:06:39","slug":"espoir-pour-les-diabetiques-un-pancreas-artificiel-made-in-israel-pourrait-etre-commercialise-dici-5-ans","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/espoir-pour-les-diabetiques-un-pancreas-artificiel-made-in-israel-pourrait-etre-commercialise-dici-5-ans\/","title":{"rendered":"Espoir pour les diab\u00e9tiques: un pancr\u00e9as artificiel made in Israel pourrait \u00eatre commercialis\u00e9 d’ici 5 ans"},"content":{"rendered":"

La start-up isra\u00e9lienne Betalin Therapeutics a annonc\u00e9 qu’elle avait lanc\u00e9 le processus de candidature pour les essais cliniques de son pancr\u00e9as artificiel r\u00e9volutionnaire.<\/strong><\/em><\/p>\n

Par Isra\u00ebl 21<\/em><\/p>\n

Le micro-pancr\u00e9as d’ing\u00e9nierie (EMP) de Betalin vise \u00e0 lib\u00e9rer les patients souffrant des types de diab\u00e8te les plus s\u00e9v\u00e8res de la surveillance constante de la glyc\u00e9mie et des injections d’insuline. Environ 160 millions de personnes dans le monde d\u00e9pendent de cette hormone pour survivre.<\/p>\n

Le chemin pour cr\u00e9er un pancr\u00e9as artificiel fabriqu\u00e9 en Isra\u00ebl est encore long. Lorsque ISRAEL21c en Espa\u00f1ol a signal\u00e9 pour la premi\u00e8re fois l’activit\u00e9 de Betalin en 2016, la soci\u00e9t\u00e9 venait d’\u00eatre fond\u00e9e sur la base de recherches men\u00e9es dans le laboratoire du professeur Eduardo Mitrani, qui si\u00e8ge toujours au conseil consultatif scientifique de la soci\u00e9t\u00e9 \u00e0 l’Universit\u00e9 h\u00e9bra\u00efque de J\u00e9rusalem.<\/p>\n

Dans le diab\u00e8te de type 1, les cellules productrices d’insuline du pancr\u00e9as ne fonctionnent pas correctement. Les m\u00e9decins ont essay\u00e9 d’implanter \u00e0 des patients des \u00eelots de cellules b\u00eata pr\u00e9lev\u00e9s sur le pancr\u00e9as d’un donneur. Malheureusement, les cellules implant\u00e9es ne survivent pas longtemps, m\u00eame avec la stimulation de m\u00e9dicaments immunosuppresseurs.
\nLa moiti\u00e9 de tous les patients transplant\u00e9s reviennent aux injections d’insuline un an plus tard, et 90 pour cent reviennent \u00e0 une d\u00e9pendance externe \u00e0 l’hormone dans les cinq ans.<\/p>\n

Le taux de rechute est tr\u00e8s \u00e9lev\u00e9 car les cellules b\u00eata ne sont pas naturellement con\u00e7ues pour survivre par elles-m\u00eames dans le corps.<\/p>\n

\u00ab\u00a0Ces cellules doivent \u00eatre entour\u00e9es d’une sorte de tissu de soutien, ce que nous appelons un \u00e9chafaudage<\/em>\u00ab\u00a0, a expliqu\u00e9 le PDG de Betalin, Nikolai Kunicher, \u00e0 ISRAEL21c. Il a ajout\u00e9 : \u00ab L’\u00e9chafaudage imite l’environnement naturel auquel les cellules du corps sont habitu\u00e9es. Cela les aide \u00e0 mieux fonctionner et \u00e0 vivre plus longtemps<\/em>.\u00a0\u00bb<\/p>\n

L’EMP est \u00ab l’\u00e9chafaudage<\/em> \u00bb de Betalin. Mesurant sept millim\u00e8tres de diam\u00e8tre et 300 microns d’\u00e9paisseur, l’appareil est compos\u00e9 de tissu pulmonaire de porc et de cellules b\u00eata s\u00e9cr\u00e9trices d’insuline, provenant soit d’un donneur, soit cr\u00e9\u00e9es en laboratoire.<\/p>\n

L’EMP ne d\u00e9clenche pas un pancr\u00e9as d\u00e9fectueux mais le remplace en fait. \u00ab\u00a0Le pancr\u00e9as artificiel d\u00e9tecte le niveau de glucose dans le corps et les cellules b\u00eata s\u00e9cr\u00e8tent la quantit\u00e9 optimale d’insuline\u00a0\u00bb<\/em>, a d\u00e9crit Kunicher, titulaire d’un doctorat en microbiologie.<\/p>\n

L’EMP est implant\u00e9 sous la peau – g\u00e9n\u00e9ralement dans la jambe – et seule une anesth\u00e9sie locale est utilis\u00e9e. Le dispositif adh\u00e8re alors rapidement au syst\u00e8me vasculaire. L’ensemble du processus prend g\u00e9n\u00e9ralement moins d’une heure.<\/p>\n

Betalin estime un prix d’environ 50 000 $ par implant bien que l’assurance maladie devrait couvrir la majeure partie des co\u00fbts : \u00ab Le co\u00fbt des complications li\u00e9es au diab\u00e8te et le prix de l’insuline sont si \u00e9lev\u00e9s que le gouvernement et les compagnies d’assurance vont ajouter<\/em> \u00bb, a d\u00e9clar\u00e9 Kunicher. .<\/p>\n

Le march\u00e9 mondial du diab\u00e8te de type 1 devrait repr\u00e9senter 25 milliards de dollars d’ici 2024. L’Organisation mondiale de la sant\u00e9 estime que pr\u00e8s de 500 millions de personnes dans le monde souffrent de diab\u00e8te de type 1 ou de type 2, soit environ 8,8 % de la population adulte. Le diab\u00e8te double le risque de d\u00e9c\u00e8s pr\u00e9matur\u00e9.<\/p>\n

Pour Betalin Therapeutics, le plus dur est d’acqu\u00e9rir suffisamment de cellules b\u00eata pour remplir un EMP. Actuellement, le seul moyen d’obtenir ces types de cellules humaines est d’utiliser un cadavre. Jusqu’\u00e0 trois donneurs sont n\u00e9cessaires pour chaque patient pour fournir les 400 000 \u00e0 500 000 \u00eelots requis par perfusion.<\/p>\n

Cela a conduit \u00e0 la cr\u00e9ation d’un cr\u00e9neau de technologie m\u00e9dicale tr\u00e8s pris\u00e9 pour les entreprises qui cr\u00e9ent des cellules b\u00eata en laboratoire. En septembre, par exemple, Vertex Pharmaceuticals a pay\u00e9 950 millions de dollars pour acqu\u00e9rir Semma Therapeutics, bas\u00e9e \u00e0 Boston, une soci\u00e9t\u00e9 qui d\u00e9rive des \u00eelots de cellules b\u00eata \u00e0 partir de cellules souches humaines.<\/p>\n

Selon Kunicher, Betalin peut utiliser des cellules b\u00eata de tiers comme Semma, mais la soci\u00e9t\u00e9 travaille \u00e9galement \u00e0 produire les siennes.
\nEn ce sens, Betalin a r\u00e9cemment re\u00e7u une subvention de collaboration binationale de l’Autorit\u00e9 isra\u00e9lienne de l’innovation et du gouvernement italien pour travailler avec le professeur Lorenzo Piemonti, expert en cellules b\u00eata et chercheur en transplantation.<\/p>\n

Les patients diab\u00e9tiques devront attendre quelques ann\u00e9es avant que la technologie ne soit enti\u00e8rement test\u00e9e. Jusqu’\u00e0 pr\u00e9sent, Betalin n’a effectu\u00e9 des tests que sur des souris.<\/p>\n

Kunicher a expliqu\u00e9 qu’il faudra encore un an et des d\u00e9penses suppl\u00e9mentaires de 5 millions de dollars pour que la soci\u00e9t\u00e9 termine tous les travaux r\u00e9glementaires n\u00e9cessaires pour commencer les tests humains. Betalin a \u00e9tabli des collaborations internationales de test avec des cliniques en Allemagne, en Angleterre, aux \u00c9tats-Unis, en Italie et en Chine.<\/p>\n

Si tout se passe bien, il faudra encore cinq ans avant que l’EMP n’arrive sur le march\u00e9.<\/p>\n

Laboratoires Betal sont situ\u00e9s dans le bioparc de J\u00e9rusalem, sur le campus du centre m\u00e9dical de l’universit\u00e9 h\u00e9bra\u00efque Hadassah. L\u00e0, o\u00f9 les espoirs sont berc\u00e9s pour des millions de diab\u00e9tiques \u00e0 travers le monde.<\/p>\n

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La start-up isra\u00e9lienne Betalin Therapeutics a annonc\u00e9 qu’elle avait lanc\u00e9 le processus de candidature pour les essais cliniques de son pancr\u00e9as artificiel r\u00e9volutionnaire. Par Isra\u00ebl 21 Le micro-pancr\u00e9as d’ing\u00e9nierie (EMP) de Betalin vise \u00e0 lib\u00e9rer les patients souffrant des types de diab\u00e8te les plus s\u00e9v\u00e8res de la surveillance constante de la glyc\u00e9mie et des injections… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":406290,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[35948,34248,29798,34490,29783,28445],"class_list":["post-406281","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-diabete","tag-innovation-fr","tag-medecine","tag-pancreas-fr","tag-sante","tag-technologie"],"better_featured_image":{"id":406290,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1707,"file":"2021\/11\/shutterstock_1044227548-scaled.jpg","sizes":{"medium":{"file":"shutterstock_1044227548-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-300x200.jpg"},"large":{"file":"shutterstock_1044227548-1024x683.jpg","width":1024,"height":683,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-1024x683.jpg"},"thumbnail":{"file":"shutterstock_1044227548-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-150x150.jpg"},"medium_large":{"file":"shutterstock_1044227548-768x512.jpg","width":768,"height":512,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-768x512.jpg"},"1536x1536":{"file":"shutterstock_1044227548-1536x1024.jpg","width":1536,"height":1024,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-1536x1024.jpg"},"2048x2048":{"file":"shutterstock_1044227548-2048x1365.jpg","width":2048,"height":1365,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-2048x1365.jpg"},"uwi-full-width":{"file":"shutterstock_1044227548-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1044227548-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1044227548-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1044227548-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1044227548-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1044227548-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1044227548-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-250x170.jpg"},"uwi-email":{"file":"shutterstock_1044227548-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1044227548-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_1044227548-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_1044227548-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/11\/shutterstock_1044227548-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_1044227548-2048x1536.jpg","width":2048,"height":1536,"m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