{"id":399084,"date":"2021-08-23T14:15:53","date_gmt":"2021-08-23T11:15:53","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=399084"},"modified":"2021-08-24T11:37:50","modified_gmt":"2021-08-24T08:37:50","slug":"coronavirus-israel-decouvre-un-medicament-ultra-efficace","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/coronavirus-israel-decouvre-un-medicament-ultra-efficace\/","title":{"rendered":"Coronavirus: Isra\u00ebl d\u00e9couvre un m\u00e9dicament ultra efficace"},"content":{"rendered":"

Les patients ayant re\u00e7u du TriCor hypolip\u00e9miant ont pu arr\u00eater l’oxyg\u00e9noth\u00e9rapie au bout d’une semaine.<\/strong><\/em><\/p>\n

Par TPS<\/em><\/p>\n

Une \u00e9tude de l’Universit\u00e9 h\u00e9bra\u00efque a d\u00e9montr\u00e9 qu’un m\u00e9dicament hypolipid\u00e9miant r\u00e9duisait l’inflammation chez les patients atteints de coronavirus (COVID-19) en 48 heures et supprimait le besoin d’oxyg\u00e8ne en cinq \u00e0 sept jours.<\/p>\n

Le virus SARS-CoV-2 a infect\u00e9 plus de 165 millions de personnes dans le monde, causant pr\u00e8s de 3,5 millions de d\u00e9c\u00e8s. Les r\u00e9cents efforts de vaccination ont \u00e9t\u00e9 entrav\u00e9s par de multiples variants du coronavirus qui remettent en cause les vaccins existants.<\/p>\n

Alors que l’infection produit g\u00e9n\u00e9ralement une maladie b\u00e9nigne, chez certains patients, elle peut se transformer en un COVID-19 inflammatoire s\u00e9v\u00e8re n\u00e9cessitant une intervention m\u00e9dicale.<\/p>\n

R\u00e9cemment, l’\u00e9quipe du professeur Yaakov Nahmias de l’Universit\u00e9 h\u00e9bra\u00efque de J\u00e9rusalem a signal\u00e9 que le nouveau coronavirus provoquait une accumulation anormale de lipides, connus pour d\u00e9clencher une inflammation s\u00e9v\u00e8re lors d’un processus appel\u00e9 lipotoxicit\u00e9.<\/p>\n

L’\u00e9quipe a identifi\u00e9 le m\u00e9dicament hypolipid\u00e9miant TriCor (f\u00e9nofibrate) comme un antiviral efficace l’ann\u00e9e derni\u00e8re, montrant en laboratoire qu’il r\u00e9duisait \u00e0 la fois les dommages caus\u00e9s aux cellules pulmonaires et permettait de bloquer la r\u00e9plication du virus. Ces r\u00e9sultats ont depuis \u00e9t\u00e9 confirm\u00e9s par plusieurs \u00e9quipes de recherche internationales.<\/p>\n

Une \u00e9tude observationnelle men\u00e9e dans plusieurs centres cliniques en Isra\u00ebl a \u00e9t\u00e9 rapport\u00e9e en octobre dernier pour \u00e9tayer les r\u00e9sultats originaux. L\u2019\u00e9quipe a ensuite lanc\u00e9 une \u00e9tude clinique interventionnelle pour traiter les patients atteints de COVID-19 s\u00e9v\u00e8res au centre m\u00e9dical isra\u00e9lien Barzilai avec le soutien des laboratoires Abbott.<\/p>\n

Aujourd’hui, l’\u00e9quipe de l’Universit\u00e9 H\u00e9bra\u00efque rapporte les r\u00e9sultats prometteurs d’une \u00e9tude clinique interventionnelle ouverte lanc\u00e9e par un chercheur, dirig\u00e9e par Nahmias et coordonn\u00e9e par le professeur Shlomo Maayan, chef de l’unit\u00e9 des maladies infectieuses \u00e0 Barzilai.<\/p>\n

Dans cette \u00e9tude ouverte, 15 patients COVID-19 hospitalis\u00e9s s\u00e9v\u00e8rement atteints de pneumonie n\u00e9cessitant une assistance en oxyg\u00e8ne ont \u00e9t\u00e9 trait\u00e9s. En plus des soins standard, les patients ont re\u00e7u 145 mg\/jour de TriCor pendant 10 jours et ont \u00e9t\u00e9 surveill\u00e9s en continu pour la progression de la maladie et les r\u00e9sultats.<\/p>\n

\u00ab Les r\u00e9sultats ont \u00e9t\u00e9 \u00e9poustouflants<\/em> \u00bb, a partag\u00e9 Nahmias. \u00ab\u00a0Les marqueurs d’inflammation progressive, qui sont la marque de fabrique de la d\u00e9t\u00e9rioration du COVID-19, ont chut\u00e9 dans les 48 heures suivant le traitement. De plus, 14 des 15 patients s\u00e9v\u00e8res n’ont pas eu besoin d’une assistance en oxyg\u00e8ne dans la semaine suivant le traitement, tandis que les archives historiques montrent que la grande majorit\u00e9 des patients s\u00e9v\u00e8res trait\u00e9s avec les soins standard n\u00e9cessitent une longue assistance respiratoire<\/em> \u00bb, a-t-il ajout\u00e9.<\/p>\n

Ces r\u00e9sultats sont prometteurs car TriCor a \u00e9t\u00e9 approuv\u00e9 par la FDA en 1975 pour une utilisation \u00e0 long terme et a un solide dossier de s\u00e9curit\u00e9.<\/p>\n

\u00ab\u00a0Il n’y a pas de solution miracle<\/em>\u00ab\u00a0, a soulign\u00e9 Nahmias, \u00ab\u00a0mais le f\u00e9nofibrate est bien plus s\u00fbr que les autres m\u00e9dicaments propos\u00e9s \u00e0 ce jour, et son m\u00e9canisme d’action le rend moins susceptible d’\u00eatre sp\u00e9cifique \u00e0 un variant<\/em>\u00ab\u00a0.<\/p>\n

\u00ab\u00a0Tous les patients ont pu quitter l’h\u00f4pital moins d’une semaine apr\u00e8s le d\u00e9but du traitement et ont termin\u00e9 le traitement de 10 jours \u00e0 domicile, sans qu’aucun effet ind\u00e9sirable li\u00e9 au m\u00e9dicament ne soit signal\u00e9<\/em>\u00ab\u00a0, a not\u00e9 Maayan.<\/p>\n

\u00ab De plus, moins de patients ont signal\u00e9 des effets secondaires du COVID-19 lors de leur rendez-vous de suivi de 4 semaines \u00bb<\/em>, a-t-il ajout\u00e9. \u00ab\u00a0Ces r\u00e9sultats pr\u00e9liminaires offrent la promesse de soulager les fardeaux de sant\u00e9 substantiels subis par les patients qui survivent \u00e0 la phase aigu\u00eb de COVID-19<\/em> \u00bb, a-t-il d\u00e9clar\u00e9.<\/p>\n

Les chercheurs ont soulign\u00e9 que m\u00eame si les r\u00e9sultats \u00e9taient extr\u00eamement prometteurs, seules des \u00e9tudes randomis\u00e9es contr\u00f4l\u00e9es par placebo pouvaient servir de base aux d\u00e9cisions cliniques. \u00ab Nous sommes entr\u00e9s dans la deuxi\u00e8me phase de l’\u00e9tude et recrutons activement des patients<\/em> \u00bb, a expliqu\u00e9 Nahmias, notant que deux \u00e9tudes de phase 3 sont d\u00e9j\u00e0 men\u00e9es en Am\u00e9rique du Sud, aux \u00c9tats-Unis et en Isra\u00ebl.<\/p>\n

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Les patients ayant re\u00e7u du TriCor hypolip\u00e9miant ont pu arr\u00eater l’oxyg\u00e9noth\u00e9rapie au bout d’une semaine. Par TPS Une \u00e9tude de l’Universit\u00e9 h\u00e9bra\u00efque a d\u00e9montr\u00e9 qu’un m\u00e9dicament hypolipid\u00e9miant r\u00e9duisait l’inflammation chez les patients atteints de coronavirus (COVID-19) en 48 heures et supprimait le besoin d’oxyg\u00e8ne en cinq \u00e0 sept jours. Le virus SARS-CoV-2 a infect\u00e9 plus… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":384171,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[37426,37424,34248,29798,31464,29783,28846],"class_list":["post-399084","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-coronavirus-fr","tag-epidemie","tag-innovation-fr","tag-medecine","tag-medicament","tag-sante","tag-traitement"],"better_featured_image":{"id":384171,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1810,"file":"2021\/03\/shutterstock_1899664549-scaled.jpg","sizes":{"medium":{"file":"shutterstock_1899664549-300x212.jpg","width":300,"height":212,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-300x212.jpg"},"large":{"file":"shutterstock_1899664549-1024x724.jpg","width":1024,"height":724,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-1024x724.jpg"},"thumbnail":{"file":"shutterstock_1899664549-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-150x150.jpg"},"medium_large":{"file":"shutterstock_1899664549-768x543.jpg","width":768,"height":543,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-768x543.jpg"},"1536x1536":{"file":"shutterstock_1899664549-1536x1086.jpg","width":1536,"height":1086,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-1536x1086.jpg"},"2048x2048":{"file":"shutterstock_1899664549-2048x1448.jpg","width":2048,"height":1448,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-2048x1448.jpg"},"uwi-full-width":{"file":"shutterstock_1899664549-736x520.jpg","width":736,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-736x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1899664549-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1899664549-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1899664549-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1899664549-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1899664549-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1899664549-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-250x170.jpg"},"uwi-email":{"file":"shutterstock_1899664549-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1899664549-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_1899664549-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_1899664549-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/03\/shutterstock_1899664549-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_1899664549-2048x1536.jpg","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