{"id":398733,"date":"2021-08-18T13:30:54","date_gmt":"2021-08-18T10:30:54","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=398733"},"modified":"2021-08-19T18:01:45","modified_gmt":"2021-08-19T15:01:45","slug":"pourquoi-les-personnes-agees-sont-davantage-menacees-par-le-coronavirus-une-etude-israelienne-a-permis-de-trouver-la-reponse","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/pourquoi-les-personnes-agees-sont-davantage-menacees-par-le-coronavirus-une-etude-israelienne-a-permis-de-trouver-la-reponse\/","title":{"rendered":"Pourquoi les personnes \u00e2g\u00e9es sont davantage menac\u00e9es par le Coronavirus? Une \u00e9tude isra\u00e9lienne a permis de trouver la r\u00e9ponse!"},"content":{"rendered":"

Davantage de rappels ou la combinaison de diff\u00e9rents types de vaccins pourraient mieux fonctionner chez les personnes \u00e2g\u00e9es, d’apr\u00e8s les connaissances du Technion sur le vieillissement du syst\u00e8me immunitaire.<\/strong><\/em><\/p>\n

Par Abigail Klein Leichman, ISRAEL21c<\/em><\/p>\n

La population \u00e2g\u00e9e semble \u00eatre plus vuln\u00e9rable au Covid-19, et les vaccins sont moins efficaces pour les prot\u00e9ger. D\u00e9sormais, nous savons pourquoi.<\/p>\n

Pour sa th\u00e8se de doctorat, sous la direction du professeur d’immunologie Doron Melamed, Reem Dowery, \u00e9tudiante dipl\u00f4m\u00e9e du Technion-Israel Institute of Technology, a explor\u00e9 le processus de vieillissement du syst\u00e8me immunitaire et les moyens de le rajeunir.<\/p>\n

Les r\u00e9sultats apparaissent dans la revue Blood.<\/p>\n

Dowery a expliqu\u00e9 que les cellules du syst\u00e8me immunitaire appel\u00e9es lymphocytes B m\u00e9moire \u00e9taient responsables de la production \u00e0 long terme d’anticorps efficaces. Ils se forment en r\u00e9ponse \u00e0 un nouvel agent pathog\u00e8ne tel qu’un virus. Les expositions ult\u00e9rieures \u00e0 cet agent pathog\u00e8ne d\u00e9clenchent une r\u00e9ponse immunitaire acc\u00e9l\u00e9r\u00e9e et augment\u00e9e de ces cellules m\u00e9moires pendant de nombreuses ann\u00e9es.<\/p>\n

Les scientifiques savaient d\u00e9j\u00e0 que la formation de lymphocytes B m\u00e9moire n’\u00e9tait pas aussi efficace chez la population \u00e2g\u00e9e, ce qui les expose \u00e0 un plus grand risque face \u00e0 de nouveaux agents pathog\u00e8nes tels que le coronavirus SARS-CoV-2.<\/p>\n

L’\u00e9tude men\u00e9e dans le laboratoire de Melamed a r\u00e9v\u00e9l\u00e9 que, dans le cadre du processus de vieillissement, les lymphocytes B m\u00e9moire existants utilisent des signaux hormonaux pour entraver la production de nouveaux lymphocytes. En cons\u00e9quence, le syst\u00e8me immunitaire r\u00e9agit mieux aux agents pathog\u00e8nes qu’il a rencontr\u00e9s auparavant, mais se r\u00e9v\u00e8le moins capable de s’adapter aux nouvelles menaces.<\/p>\n

\u00c0 la recherche d’une solution \u00e0 ce probl\u00e8me, le laboratoire de Melamed a collabor\u00e9 avec les d\u00e9partements d’h\u00e9matologie et de rhumatologie du Tel Aviv Sourasky Medical Center et du Rambam Health Care Campus \u00e0 Ha\u00effa, respectivement.<\/p>\n

Ils ont examin\u00e9 des patients \u00e2g\u00e9s qui avaient subi une d\u00e9pl\u00e9tion en lymphocytes B comme traitement pour des affections telles que le lupus, le lymphome et la scl\u00e9rose en plaques. Ils ont d\u00e9couvert qu’apr\u00e8s l’\u00e9limination d’une quantit\u00e9 importante de lymphocytes B m\u00e9moire, le syst\u00e8me immunitaire des patients \u00e9tait rajeuni et recommen\u00e7ait \u00e0 produire de nouveaux lymphocytes B m\u00e9moire tr\u00e8s puissants.<\/p>\n

Dowery et Melamed offrent la possibilit\u00e9 d’utiliser l’hormonoth\u00e9rapie pour d\u00e9clencher l’\u00e9puisement des cellules B et le rajeunissement du syst\u00e8me immunitaire.<\/p>\n

Melamed a d\u00e9clar\u00e9 \u00e0 ISRAEL21c que les nouvelles informations pourraient entra\u00eener des changements pratiques dans la pr\u00e9vention de l’infection \u00e0 Covid chez les personnes \u00e2g\u00e9es.<\/p>\n

\u00ab Un bon exemple est d’adapter une strat\u00e9gie de vaccination appropri\u00e9e pour les personnes \u00e2g\u00e9es. Si ce groupe de personnes ne parvient pas \u00e0 g\u00e9n\u00e9rer une bonne m\u00e9moire durable au Covid, peut-\u00eatre qu’en utilisant une strat\u00e9gie de vaccination plus fr\u00e9quente comme approche pr\u00e9ventive, cette population sera plus prot\u00e9g\u00e9e<\/em> \u00bb, dit-il.<\/p>\n

\u00ab Un autre exemple consiste \u00e0 envisager d’utiliser une technologie vaccinale diff\u00e9rente en combinaison avec la strat\u00e9gie actuelle de vaccination bas\u00e9e sur l’ARNm. Cela pourrait peut-\u00eatre activer des voies immunologiques suppl\u00e9mentaires qui pourraient compenser la formation alt\u00e9r\u00e9e de la m\u00e9moire [immune].<\/em>\u00ab\u00a0<\/p>\n

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Davantage de rappels ou la combinaison de diff\u00e9rents types de vaccins pourraient mieux fonctionner chez les personnes \u00e2g\u00e9es, d’apr\u00e8s les connaissances du Technion sur le vieillissement du syst\u00e8me immunitaire. Par Abigail Klein Leichman, ISRAEL21c La population \u00e2g\u00e9e semble \u00eatre plus vuln\u00e9rable au Covid-19, et les vaccins sont moins efficaces pour les prot\u00e9ger. D\u00e9sormais, nous savons… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":398736,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[41155,28414],"tags":[37426,37424,28978,29798,29313,29783,29952],"class_list":["post-398733","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-combat-disrael-contre-le-covid-19","category-influence-israelienne","tag-coronavirus-fr","tag-epidemie","tag-etude","tag-medecine","tag-recherche","tag-sante","tag-vaccin"],"better_featured_image":{"id":398736,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1707,"file":"2021\/08\/shutterstock_1944759274-scaled.jpg","sizes":{"medium":{"file":"shutterstock_1944759274-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-300x200.jpg"},"large":{"file":"shutterstock_1944759274-1024x683.jpg","width":1024,"height":683,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-1024x683.jpg"},"thumbnail":{"file":"shutterstock_1944759274-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-150x150.jpg"},"medium_large":{"file":"shutterstock_1944759274-768x512.jpg","width":768,"height":512,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-768x512.jpg"},"1536x1536":{"file":"shutterstock_1944759274-1536x1024.jpg","width":1536,"height":1024,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-1536x1024.jpg"},"2048x2048":{"file":"shutterstock_1944759274-2048x1365.jpg","width":2048,"height":1365,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-2048x1365.jpg"},"uwi-full-width":{"file":"shutterstock_1944759274-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1944759274-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1944759274-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1944759274-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1944759274-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1944759274-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1944759274-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-250x170.jpg"},"uwi-email":{"file":"shutterstock_1944759274-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1944759274-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_1944759274-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_1944759274-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/08\/shutterstock_1944759274-1024x768.jpg"},"uwi-ipad-x2":{"file":"shut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