{"id":395832,"date":"2021-07-22T12:48:43","date_gmt":"2021-07-22T09:48:43","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=395832"},"modified":"2021-07-23T10:22:58","modified_gmt":"2021-07-23T07:22:58","slug":"israel-sur-le-point-de-produire-plusieurs-medicaments-efficaces-contre-le-coronavirus","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/israel-sur-le-point-de-produire-plusieurs-medicaments-efficaces-contre-le-coronavirus\/","title":{"rendered":"Isra\u00ebl sur le point de produire plusieurs m\u00e9dicaments efficaces contre le coronavirus"},"content":{"rendered":"

Des recherches de l’Universit\u00e9 h\u00e9bra\u00efque indiquent certains bloqueurs de canaux prometteurs qui pourraient \u00eatre \u00e9tudi\u00e9s comme traitements antiviraux pour le SRAS-CoV-2.<\/strong><\/em><\/p>\n

Par Abigail Klein Leichman, Isra\u00ebl21c<\/em><\/p>\n

De nouvelles recherches du professeur Isaiah (Shy) Arkin du d\u00e9partement de chimie biologique de l’Universit\u00e9 h\u00e9bra\u00efque de J\u00e9rusalem sugg\u00e8rent que plusieurs m\u00e9dicaments existants devraient \u00eatre \u00e9tudi\u00e9s comme traitements prometteurs pour Covid-19.<\/p>\n

Arkin et son \u00e9quipe ont recherch\u00e9 des m\u00e9dicaments antiviraux qui exploitent un maillon faible dans de nombreux virus \u2013 des prot\u00e9ines appel\u00e9es canaux ioniques.<\/p>\n

Les canaux ioniques permettent au virus de r\u00e9guler l’acidit\u00e9 et la salinit\u00e9 de son environnement interne et externe. Le blocage de ces canaux rend difficile la propagation des infections.<\/p>\n

Jusqu’\u00e0 pr\u00e9sent, un seul bloqueur de canaux ioniques est approuv\u00e9 comme traitement antiviral, et c’est pour la grippe.<\/p>\n

Arkin et son groupe se sont concentr\u00e9s sur le canal ionique de la prot\u00e9ine E dans la membrane du coronavirus. Ils ont scann\u00e9 une petite biblioth\u00e8que de substances approuv\u00e9es pour une utilisation chez l’Homme et en ont trouv\u00e9 deux qui la bloquent : le gliclazide (un m\u00e9dicament utilis\u00e9 pour traiter le diab\u00e8te) et la m\u00e9mantine (un m\u00e9dicament utilis\u00e9 pour traiter la maladie d’Alzheimer).<\/p>\n

Ensuite, ils ont scann\u00e9 une biblioth\u00e8que plus large de 2 839 substances et ont trouv\u00e9 huit autres inhibiteurs de la prot\u00e9ine E, comme indiqu\u00e9 dans la revue scientifique Pharmaceuticals.<\/p>\n

\u00c9tant donn\u00e9 que tous les inhibiteurs trouv\u00e9s sont d\u00e9j\u00e0 approuv\u00e9s pour une utilisation chez l’Homme, Arkin s’attend \u00e0 une voie rapide vers l’approbation r\u00e9glementaire pour la recherche clinique.<\/p>\n

\u00ab\u00a0Trente pour cent des m\u00e9dicaments disponibles aujourd’hui ont \u00e9t\u00e9 approuv\u00e9s de cette mani\u00e8re, y compris les m\u00e9dicaments actuellement disponibles contre le coronavirus ou ceux r\u00e9cemment test\u00e9s contre ce virus<\/em>\u00ab\u00a0, a d\u00e9clar\u00e9 Arkin.<\/p>\n

En effet, des recherches isra\u00e9liennes ant\u00e9rieures ont identifi\u00e9 plusieurs autres m\u00e9dicaments existants qui pourraient \u00eatre utilis\u00e9s pour traiter le Covid-19.<\/p>\n

Il a ajout\u00e9 qu’il est prudent de supposer que les inhibiteurs de la prot\u00e9ine E \u2013 un composant essentiel du SRAS-CoV-2 \u2013 seraient pertinents contre les variants, m\u00eame ceux contre lesquelles les vaccins actuels sont moins efficaces.<\/p>\n

\u00ab Le sentiment g\u00e9n\u00e9ral en Isra\u00ebl et dans le monde est que s’il existe des vaccins, il n’y a aucune raison de continuer \u00e0 travailler sur [des traitements contre] le virus parce que nous avons trouv\u00e9 une solution. Malheureusement, si nous comptons sur une seule solution, le vaccin, nous pouvons nous retrouver dans une situation o\u00f9 un nouveau variant [r\u00e9siste au vaccin]<\/em> \u00bb, a d\u00e9clar\u00e9 Arkin. \u00ab\u00a0Nous n’en sommes pas encore l\u00e0, mais les variants \u00e0 travers le monde sont un feu d’avertissement<\/em>.\u00a0\u00bb<\/p>\n

Son groupe esp\u00e8re publier une autre \u00e9tude sur l’efficacit\u00e9 des inhibiteurs contre l’ensemble du virus et pas seulement contre la prot\u00e9ine E.<\/p>\n

\u00ab\u00a0La sc\u00e8ne est maintenant pr\u00eate pour des \u00e9tudes in vitro et in vivo (dans des installations de bios\u00e9curit\u00e9 appropri\u00e9es) pour examiner les effets des compos\u00e9s sur le virus<\/em>\u00ab\u00a0, ont conclu les chercheurs.<\/p>\n

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Des recherches de l’Universit\u00e9 h\u00e9bra\u00efque indiquent certains bloqueurs de canaux prometteurs qui pourraient \u00eatre \u00e9tudi\u00e9s comme traitements antiviraux pour le SRAS-CoV-2. Par Abigail Klein Leichman, Isra\u00ebl21c De nouvelles recherches du professeur Isaiah (Shy) Arkin du d\u00e9partement de chimie biologique de l’Universit\u00e9 h\u00e9bra\u00efque de J\u00e9rusalem sugg\u00e8rent que plusieurs m\u00e9dicaments existants devraient \u00eatre \u00e9tudi\u00e9s comme traitements prometteurs… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":395833,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[37426,37424,31464,29783,36278,29952],"class_list":["post-395832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-coronavirus-fr","tag-epidemie","tag-medicament","tag-sante","tag-traitements","tag-vaccin"],"better_featured_image":{"id":395833,"alt_text":"","caption":"Technicians carry out a diagnostic test for coronavirus in a lab at the Rambam Hospital in Haifa, on March 30, 2020. 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