{"id":385321,"date":"2021-04-16T00:35:00","date_gmt":"2021-04-15T21:35:00","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=385321"},"modified":"2021-04-13T11:51:59","modified_gmt":"2021-04-13T08:51:59","slug":"des-israeliens-font-une-decouverte-revolutionnaire-contre-le-cancer-du-cerveau","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/des-israeliens-font-une-decouverte-revolutionnaire-contre-le-cancer-du-cerveau\/","title":{"rendered":"Des isra\u00e9liens font une d\u00e9couverte r\u00e9volutionnaire contre le cancer du cerveau"},"content":{"rendered":"

Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert que le blocage d’une certaine prot\u00e9ine aidait \u00e0 pr\u00e9venir la propagation des cellules canc\u00e9reuses du cerveau.<\/strong><\/em><\/p>\n

Par Yakir Benzion, Unis avec Isra\u00ebl<\/em><\/p>\n

Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert une solution pour emp\u00eacher certaines cellules du cerveau d’aider \u00e0 propager des excroissances canc\u00e9reuses, a annonc\u00e9 dimanche l’universit\u00e9.<\/p>\n

Ils se sont concentr\u00e9s sur un probl\u00e8me qui avait frustr\u00e9 les scientifiques concernant la raison pour laquelle le syst\u00e8me immunitaire du cerveau ne parvenait pas \u00e0 lutter contre la maladie et encourageait plut\u00f4t la division et la propagation de cellules canc\u00e9reuses mortelles du glioblastome.<\/p>\n

\u00ab\u00a0Nous \u00e9tudions le glioblastome depuis une dizaine d’ann\u00e9es. Nous sommes intrigu\u00e9s par la fa\u00e7on dont le glioblastome, un cancer du cerveau tr\u00e8s agressif, progresse si rapidement dans le cerveau et que la plupart des traitements se r\u00e9v\u00e8lent inutiles<\/em>\u00ab\u00a0, a d\u00e9clar\u00e9 le professeur Ronit Satchi-Fainaro. , Directrice du centre de recherche en biologie du cancer et chef du laboratoire de recherche sur le cancer et de nanom\u00e9decine de l’universit\u00e9.<\/p>\n

Le glioblastome est le type de cancer le plus mortel du syst\u00e8me nerveux central, repr\u00e9sentant la plupart des tumeurs c\u00e9r\u00e9brales malignes. Il est agressif, invasif et sa croissance est rapide, ce qui le rend r\u00e9sistant aux traitements existants, les patients mourant moins d’un an apr\u00e8s l’apparition du cancer. De plus, le glioblastome produit des \u00abtumeurs froides\u00bb, qui ne r\u00e9pondent pas aux tentatives immunoth\u00e9rapeutiques pour activer le syst\u00e8me immunitaire contre lui.<\/p>\n

\u00abIl y a cinq ans, nous avons d\u00e9cid\u00e9 de nous concentrer sur les interactions entre les cellules du glioblastome et les cellules r\u00e9sidentes dans le microenvironnement du cerveau. Nous nous sommes concentr\u00e9s sur la microglie. Ce sont les cellules immunitaires du cerveau<\/em>\u00bb, a-t-elle expliqu\u00e9.<\/p>\n

\u00ab\u00c0 notre grande surprise, nous avons constat\u00e9 que non seulement les cellules microgliales ne faisaient rien pour arr\u00eater les cellules canc\u00e9reuses, mais qu’elles jouaient en fait un r\u00f4le crucial et n\u00e9gatif en acc\u00e9l\u00e9rant la division, la propagation et la mobilisation des cellules du glioblastome<\/em>\u00bb, a-t-elle d\u00e9clar\u00e9.<\/p>\n

L’\u00e9quipe de Satchi-Fainaro a d\u00e9couvert que le cerveau s\u00e9cr\u00e9tait une prot\u00e9ine appel\u00e9e P-Selectin (SELP), qui modifie les cellules immunitaires du cerveau de sorte qu’au lieu d’inhiber la propagation des cellules canc\u00e9reuses, elles faisaient le contraire, leur permettant de prolif\u00e9rer et de p\u00e9n\u00e9trer dans les tissus c\u00e9r\u00e9braux. Ils ont ensuite cherch\u00e9 un moyen d’inhiber la prot\u00e9ine SELP afin que la microglie fasse ce qu’elle est cens\u00e9e faire et bloque la propagation de ce qui est normalement un cancer incurable.<\/p>\n

\u00abLa SELP est une prot\u00e9ine connue qui aide normalement les cellules \u00e0 voyager \u00e0 l’int\u00e9rieur du corps, en particulier les globules blancs et les cellules endoth\u00e9liales qui tapissent l’int\u00e9rieur des vaisseaux sanguins<\/em>\u00bb, explique Satchi-Fainaro. \u00ab\u00a0La rencontre entre les cellules de glioblastome et les cellules de microglie les am\u00e8ne \u00e0 exprimer SELP en grande quantit\u00e9. Dans l’\u00e9tude, nous avons pu montrer que le SELP surexprim\u00e9 aidait les cellules canc\u00e9reuses \u00e0 voyager et \u00e0 p\u00e9n\u00e9trer dans le tissu c\u00e9r\u00e9bral.<\/em>\u00a0\u00bb<\/p>\n

\u00abEn inhibant la s\u00e9cr\u00e9tion de cette prot\u00e9ine, nous avons en fait stopp\u00e9 la progression du glioblastome dans plusieurs mod\u00e8les, chez la souris et dans des mod\u00e8les 3D uniques de tissus c\u00e9r\u00e9braux atteints de glioblastome (pr\u00e9lev\u00e9) sur des patients<\/em>\u00bb, a d\u00e9clar\u00e9 Satchi-Fainaro.<\/p>\n

Les r\u00e9sultats de l’\u00e9tude peuvent avoir des implications th\u00e9rapeutiques vitales et par pure co\u00efncidence, une \u00e9tude clinique est d\u00e9j\u00e0 en cours pour inhiber la SELP pour une raison diff\u00e9rente – le traitement de la douleur associ\u00e9e \u00e0 la dr\u00e9panocytose.<\/p>\n

Satchi-Fainaro esp\u00e8re que puisque ce traitement semble montrer que l’inhibition de la SELP s’av\u00e8re s\u00fbre chez l’homme, les r\u00e9sultats positifs de cet essai pourraient ouvrir la voie \u00e0 l’approbation relativement rapide d’un essai clinique r\u00e9orientant le nouveau traitement du glioblastome.<\/p>\n

\u00ab\u00a0Malheureusement, les patients atteints de glioblastome ont besoin de nouveaux traitements imm\u00e9diatement. Notre traitement peut \u00eatre la perc\u00e9e n\u00e9cessaire dans la bataille contre le cancer le plus redoutable de tous<\/em>\u00ab\u00a0, a-t-elle d\u00e9clar\u00e9.<\/p>\n

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Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert que le blocage d’une certaine prot\u00e9ine aidait \u00e0 pr\u00e9venir la propagation des cellules canc\u00e9reuses du cerveau. Par Yakir Benzion, Unis avec Isra\u00ebl Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9couvert une solution pour emp\u00eacher certaines cellules du cerveau d’aider \u00e0 propager des excroissances canc\u00e9reuses, a… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":298971,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[33896,29951,34044,29306,29798,29313,29783,41087],"class_list":["post-385321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-cancer-fr","tag-cerveau","tag-decouverte","tag-maladie","tag-medecine","tag-recherche","tag-sante","tag-univeriste"],"better_featured_image":{"id":298971,"alt_text":"Cancer Cells","caption":"Cancer Cells","description":"Cancer Cells 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