{"id":384258,"date":"2021-04-01T11:40:16","date_gmt":"2021-04-01T08:40:16","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=384258"},"modified":"2021-04-01T12:33:57","modified_gmt":"2021-04-01T09:33:57","slug":"des-scientifiques-israeliens-font-une-decouverte-revolutionnaire-dans-la-lutte-contre-le-cancer","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/des-scientifiques-israeliens-font-une-decouverte-revolutionnaire-dans-la-lutte-contre-le-cancer\/","title":{"rendered":"Des scientifiques isra\u00e9liens font une d\u00e9couverte r\u00e9volutionnaire dans la lutte contre le cancer"},"content":{"rendered":"

Les scientifiques ont d\u00e9couvert que le syst\u00e8me immunitaire \u00e9tait capable de trouver des bact\u00e9ries r\u00e9sidant dans les cellules canc\u00e9reuses et de les utiliser pour provoquer une r\u00e9action immunitaire contre une tumeur.<\/strong><\/em><\/p>\n

Par Abigail Klein Leichman, Isra\u00ebl21c<\/em><\/p>\n

Le syst\u00e8me immunitaire peut trouver des bact\u00e9ries r\u00e9sidant dans les cellules canc\u00e9reuses et les exploiter pour provoquer une r\u00e9action immunitaire contre la tumeur, selon une \u00e9tude publi\u00e9e dans Nature.<\/p>\n

Une \u00e9quipe de recherche internationale, dirig\u00e9e par des chercheurs de l’Institut Weizmann des Sciences en Isra\u00ebl, affirme que cette d\u00e9couverte pourrait expliquer pourquoi le microbiome intestinal est connu pour affecter le succ\u00e8s des traitements d’immunoth\u00e9rapie contre le cancer.<\/p>\n

L’immunoth\u00e9rapie a consid\u00e9rablement am\u00e9lior\u00e9 les taux de gu\u00e9rison de certains cancers, en particulier le m\u00e9lanome malin, mais ne fonctionne toujours que dans environ 40 pour cent des cas.<\/p>\n

Le biologiste des cellules mol\u00e9culaires Ravid Straussman, l’un des premiers \u00e0 r\u00e9v\u00e9ler des bact\u00e9ries dans les cellules canc\u00e9reuses, a con\u00e7u des m\u00e9thodes permettant au professeur Yardena Samuels et \u00e0 son laboratoire de rechercher des signalisations indiquant ces bact\u00e9ries.<\/p>\n

Les auteurs principaux Shelly Kalaora et Adi Nagler ont analys\u00e9 des \u00e9chantillons de tissus de 17 tumeurs de m\u00e9lanome m\u00e9tastatique provenant de neuf patients. Ils ont obtenu des profils g\u00e9nomiques bact\u00e9riens de ces tumeurs puis identifi\u00e9 pr\u00e8s de 300 peptides tumoraux reconnaissables par le syst\u00e8me immunitaire.<\/p>\n

Des \u00e9tudes futures pourraient d\u00e9terminer quels peptides bact\u00e9riens am\u00e9liorent la r\u00e9ponse immunitaire, permettant aux m\u00e9decins de pr\u00e9dire le succ\u00e8s de l’immunoth\u00e9rapie et d’adapter un traitement personnalis\u00e9 en cons\u00e9quence.<\/p>\n

\u00abBeaucoup de ces peptides \u00e9taient partag\u00e9s par diff\u00e9rentes m\u00e9tastases du m\u00eame patient ou par des tumeurs de diff\u00e9rents patients, ce qui sugg\u00e8re qu’ils ont un potentiel th\u00e9rapeutique et une puissante capacit\u00e9 \u00e0 produire une activation immunitaire<\/em>\u00bb, a d\u00e9clar\u00e9 Nagler.<\/p>\n

\u00abNos r\u00e9sultats sugg\u00e8rent que les peptides bact\u00e9riens pr\u00e9sent\u00e9s sur les cellules tumorales peuvent servir de cibles potentielles pour l’immunoth\u00e9rapie<\/em>\u00bb, a d\u00e9clar\u00e9 Samuels. \u00abIls peuvent \u00eatre exploit\u00e9s pour aider les cellules T immunitaires \u00e0 reconna\u00eetre la tumeur avec une plus grande pr\u00e9cision, afin que ces cellules puissent monter une meilleure attaque contre le cancer. Cette approche pourra \u00e0 l\u2019avenir \u00eatre utilis\u00e9e en association avec des m\u00e9dicaments d\u2019immunoth\u00e9rapie existants.<\/em> \u00bb<\/p>\n

Les collaborateurs de l\u2019\u00e9tude venaient du Technion – Institut isra\u00e9lien de technologie; Centre m\u00e9dical de l’Universit\u00e9 h\u00e9bra\u00efque de Hadassah; Universit\u00e9 de Tel Aviv; Universit\u00e9 ouverte d’Isra\u00ebl; Universit\u00e9 du Texas MD Anderson Cancer Center; Universit\u00e9 Texas A&M; Sanford Burnham Prebys Medical Discovery Institute en Californie; l’Institut national du cancer des \u00c9tats-Unis; Wellcome Sanger Institute, Cambridge, Royaume-Uni; et l’Institut n\u00e9erlandais du cancer.<\/p>\n

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Les scientifiques ont d\u00e9couvert que le syst\u00e8me immunitaire \u00e9tait capable de trouver des bact\u00e9ries r\u00e9sidant dans les cellules canc\u00e9reuses et de les utiliser pour provoquer une r\u00e9action immunitaire contre une tumeur. Par Abigail Klein Leichman, Isra\u00ebl21c Le syst\u00e8me immunitaire peut trouver des bact\u00e9ries r\u00e9sidant dans les cellules canc\u00e9reuses et les exploiter pour provoquer une r\u00e9action… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":298971,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[38476,33896,34044,34248,29798,29313],"class_list":["post-384258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-bonne-nouvelle","tag-cancer-fr","tag-decouverte","tag-innovation-fr","tag-medecine","tag-recherche"],"better_featured_image":{"id":298971,"alt_text":"Cancer Cells","caption":"Cancer 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