{"id":380191,"date":"2021-02-20T21:07:24","date_gmt":"2021-02-20T18:07:24","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=380191"},"modified":"2021-02-22T11:12:36","modified_gmt":"2021-02-22T08:12:36","slug":"decouverte-israelienne-une-therapie-genique-pourrait-soigner-la-surdite","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/decouverte-israelienne-une-therapie-genique-pourrait-soigner-la-surdite\/","title":{"rendered":"D\u00e9couverte isra\u00e9lienne: une th\u00e9rapie g\u00e9nique pourrait soigner la surdit\u00e9"},"content":{"rendered":"

Le remplacement de g\u00e8nes d\u00e9fectueux qui causent une perte auditive progressive a r\u00e9ussi chez la souris et pourrait conduire au traitement de b\u00e9b\u00e9s pr\u00e9sentant des mutations similaires.<\/strong><\/em><\/p>\n

Par: Abigail Klein Leichman<\/em><\/p>\n

Une nouvelle \u00e9tude de l’Universit\u00e9 de Tel Aviv (TAU) a r\u00e9v\u00e9l\u00e9 que le nouveau traitement emp\u00eachait la d\u00e9t\u00e9rioration progressive de l’audition chez ces souris, ce qui pourrait conduire \u00e0 une perc\u00e9e dans le traitement des enfants n\u00e9s avec diverses mutations qui finissent par provoquer une perte de l’audition.<\/p>\n

La recherche, dirig\u00e9e par le professeur Karen Avraham du D\u00e9partement de g\u00e9n\u00e9tique mol\u00e9culaire humaine et de biochimie de la Sackler School of Medicine and Neuroscience de TAU, a \u00e9t\u00e9 publi\u00e9e le 22 d\u00e9cembre.<\/p>\n

La surdit\u00e9 est la d\u00e9ficience sensorielle la plus r\u00e9pandue dans le monde et selon l’Organisation mondiale de la sant\u00e9, pr\u00e8s de 500 millions de personnes souffrent d’une perte auditive (ce nombre devrait doubler au cours des prochaines d\u00e9cennies).<\/p>\n

Les statistiques indiquent \u00e9galement qu’un enfant sur 200 na\u00eet avec une d\u00e9ficience auditive et un sur 1 000 na\u00eet totalement sourd.
\nDans environ la moiti\u00e9 de ces cas, la perte auditive est caus\u00e9e par une mutation g\u00e9n\u00e9tique, 100 g\u00e8nes diff\u00e9rents pouvant \u00eatre associ\u00e9s \u00e0 la surdit\u00e9 h\u00e9r\u00e9ditaire.<\/p>\n

\u00abAu cours de l’\u00e9tude, nous nous sommes concentr\u00e9s sur la perte auditive g\u00e9n\u00e9tique caus\u00e9e par une mutation du g\u00e8ne SYNE4, une surdit\u00e9 rare d\u00e9couverte par notre laboratoire il y a plusieurs ann\u00e9es chez deux familles isra\u00e9liennes, et depuis lors identifi\u00e9e en Turquie et \u00e9galement au Royaume-Uni. Les enfants qui h\u00e9ritent du g\u00e8ne d\u00e9fectueux des deux parents naissent avec une audition normale mais perdent progressivement leur audition au cours de l’enfance. La mutation provoque une localisation incorrecte des noyaux cellulaires dans les cellules cili\u00e9es de la cochl\u00e9e de l’oreille interne, qui servent de r\u00e9cepteurs pour les ondes sonores et sont essentielles pour l’audition. Ce d\u00e9faut conduit \u00e0 la d\u00e9g\u00e9n\u00e9rescence et \u00e0 la mort \u00e9ventuelle des cellules cili\u00e9es<\/em> \u00bb, a expliqu\u00e9 Avraham.<\/p>\n

Le laboratoire d’Avraham a utilis\u00e9 une technologie de th\u00e9rapie g\u00e9nique innovante: ils ont cr\u00e9\u00e9 un virus synth\u00e9tique inoffensif qui a servi de \u00abv\u00e9hicule de livraison\u00bb pour une version normale du g\u00e8ne d\u00e9fectueux \u00e0 la fois dans le mod\u00e8le de souris et dans les familles humaines affect\u00e9es.<\/p>\n

Shahar Taiber, l’un des \u00e9tudiants du professeur Avraham sur la piste combin\u00e9e MD-PhD, a d\u00e9clar\u00e9 que l’\u00e9quipe avait inject\u00e9 le virus dans les oreilles internes des souris afin qu’il p\u00e9n\u00e8tre dans les cellules cili\u00e9es et lib\u00e8re leur charge g\u00e9n\u00e9tique et que ce faisant, ils avaient r\u00e9par\u00e9 le d\u00e9faut dans les cellules cili\u00e9es et leur avait permis de m\u00fbrir et de fonctionner normalement.<\/p>\n

Le traitement a \u00e9t\u00e9 administr\u00e9 peu de temps apr\u00e8s la naissance des souris et leur audition a ensuite \u00e9t\u00e9 contr\u00f4l\u00e9e par des tests physiologiques et comportementaux.<\/p>\n

\u00c0 son tour, le professeur Jeffrey Holt du Boston Children’s Hospital et de la Harvard Medical School, qui a collabor\u00e9 \u00e0 l’\u00e9tude, a d\u00e9clar\u00e9 que les d\u00e9couvertes \u00e9taient tr\u00e8s prometteuses puisque les souris trait\u00e9es \u00abont d\u00e9velopp\u00e9 une audition normale, avec une sensibilit\u00e9 presque identique \u00e0 celle des souris saines qui ne le font pas. avoir la mutation<\/em> \u00bb.<\/p>\n

D\u00e9sormais, les scientifiques d\u00e9veloppent d\u00e9j\u00e0 des th\u00e9rapies similaires pour d’autres mutations qui causent la surdit\u00e9.<\/p>\n

\u00ab\u00a0Il s’agit d’une \u00e9tude importante montrant que la th\u00e9rapie g\u00e9nique de l’oreille interne peut \u00eatre appliqu\u00e9e efficacement \u00e0 un mod\u00e8le de souris atteintes de surdit\u00e9 pour sauver l’audition<\/em>\u00ab\u00a0, a d\u00e9clar\u00e9 le Dr Wade Chien de l’Institut national sur la surdit\u00e9 et autres troubles.<\/p>\n

Chien a d\u00e9clar\u00e9: \u00abL’ampleur de la r\u00e9cup\u00e9ration auditive est impressionnante. Cette \u00e9tude fait partie d’un nombre croissant d’\u00e9tudes montrant que la th\u00e9rapie g\u00e9nique peut \u00eatre appliqu\u00e9e avec succ\u00e8s \u00e0 des mod\u00e8les murins de perte auditive h\u00e9r\u00e9ditaire, et illustre l’\u00e9norme potentiel de la th\u00e9rapie g\u00e9nique comme traitement de la surdit\u00e9<\/em>. \u00a0\u00bb<\/p>\n

L’\u00e9tude a \u00e9t\u00e9 soutenue par la United States-Israel Binational Science Foundation, l’Institut national de la sant\u00e9, le Conseil europ\u00e9en de la recherche et le programme Israel Precision Medicine Association de la Israel Science Foundation.<\/p>\n

Source: Isra\u00ebl21c<\/em><\/p>\n

Do You Love Israel? Make a Donation - Show Your Support!<\/h2>
\"\"<\/a>

<\/p><\/div>

Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p>

Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p>

Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. Help us fight back!<\/strong><\/a> <\/p>

STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode>

\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"

Le remplacement de g\u00e8nes d\u00e9fectueux qui causent une perte auditive progressive a r\u00e9ussi chez la souris et pourrait conduire au traitement de b\u00e9b\u00e9s pr\u00e9sentant des mutations similaires. Par: Abigail Klein Leichman Une nouvelle \u00e9tude de l’Universit\u00e9 de Tel Aviv (TAU) a r\u00e9v\u00e9l\u00e9 que le nouveau traitement emp\u00eachait la d\u00e9t\u00e9rioration progressive de l’audition chez ces souris,… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":282342,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[40718,34248,29798,29313,29783,32685,40717],"class_list":["post-380191","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-genes-fr","tag-innovation-fr","tag-medecine","tag-recherche","tag-sante","tag-sourd","tag-surdite"],"better_featured_image":{"id":282342,"alt_text":"","caption":"Deaf child","description":"","media_type":"image","media_details":{"width":1000,"height":667,"file":"2019\/01\/shutterstock_452916241.jpg","sizes":{"thumbnail":{"file":"shutterstock_452916241-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-150x150.jpg"},"medium":{"file":"shutterstock_452916241-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-300x200.jpg"},"medium_large":{"file":"shutterstock_452916241-768x512.jpg","width":768,"height":512,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-768x512.jpg"},"uwi-full-width":{"file":"shutterstock_452916241-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_452916241-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_452916241-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_452916241-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_452916241-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_452916241-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_452916241-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-250x170.jpg"},"uwi-email":{"file":"shutterstock_452916241-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_452916241-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_452916241-1000x640.jpg","width":1000,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-1000x640.jpg"},"uwi-full-width-video":{"file":"shutterstock_452916241-779x519.jpg","width":779,"height":519,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-779x519.jpg"},"uwi-fb-share-video":{"file":"shutterstock_452916241-600x315.jpg","width":600,"height":315,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-600x315.jpg"},"uwi-fb-share":{"file":"shutterstock_452916241-600x320.jpg","width":600,"height":320,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-600x320.jpg"},"uwi-featured-content-video":{"file":"shutterstock_452916241-289x159.jpg","width":289,"height":159,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-289x159.jpg"},"uwi-content-loop-video":{"file":"shutterstock_452916241-189x189.jpg","width":189,"height":189,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-189x189.jpg"},"uwi-category_list-video":{"file":"shutterstock_452916241-179x99.jpg","width":179,"height":99,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-179x99.jpg"},"uwi-tiny-video":{"file":"shutterstock_452916241-39x39.jpg","width":39,"height":39,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-39x39.jpg"},"uwi-email-featured-video":{"file":"shutterstock_452916241-249x169.jpg","width":249,"height":169,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-249x169.jpg"},"uwi-email-video":{"file":"shutterstock_452916241-209x139.jpg","width":209,"height":139,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-209x139.jpg"},"uwi-iphone-video":{"file":"shutterstock_452916241-959x639.jpg","width":959,"height":639,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-959x639.jpg"},"uwi-iphone-x2-video":{"file":"shutterstock_452916241-1000x639.jpg","width":1000,"height":639,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-1000x639.jpg"},"post-thumbnail":{"file":"shutterstock_452916241-125x125.jpg","width":125,"height":125,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241-125x125.jpg"}},"image_meta":{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"0","keywords":[]}},"post":282339,"source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2019\/01\/shutterstock_452916241.jpg"},"aioseo_notices":[],"distributor_meta":false,"distributor_terms":false,"distributor_media":false,"distributor_original_site_name":"Unis avec Isra\u00ebl","distributor_original_site_url":"https:\/\/kinsta.unitedwithisrael.org\/fr\/","push-errors":false,"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts\/380191","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/users\/4242"}],"replies":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/comments?post=380191"}],"version-history":[{"count":0,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts\/380191\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/media\/282342"}],"wp:attachment":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/media?parent=380191"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/categories?post=380191"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/tags?post=380191"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}