{"id":378722,"date":"2021-02-08T15:07:53","date_gmt":"2021-02-08T12:07:53","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=378722"},"modified":"2021-04-26T12:29:43","modified_gmt":"2021-04-26T09:29:43","slug":"israel-en-route-vers-des-traitements-tres-efficaces-contre-le-coronavirus","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/israel-en-route-vers-des-traitements-tres-efficaces-contre-le-coronavirus\/","title":{"rendered":"Isra\u00ebl en route vers des traitements tr\u00e8s efficaces contre le Coronavirus"},"content":{"rendered":"

Le m\u00e9dicament exp\u00e9rimental Covid a gu\u00e9ri 30 des 30 cas mod\u00e9r\u00e9s \u00e0 s\u00e9v\u00e8res dans le cadre de l’essai clinique de phase I \u00e0 l’h\u00f4pital isra\u00e9lien. Le deuxi\u00e8me nouveau m\u00e9dicament est \u00e9galement prometteur.<\/strong><\/em><\/p>\n

Par Abigail Klein Leichman, ISRAEL21c<\/em><\/p>\n

Bien qu’\u00e9tant leader international en mati\u00e8re de vaccination contre le Covid-19, Isra\u00ebl a constat\u00e9 que le monde avait toujours d\u00e9sesp\u00e9r\u00e9ment besoin de m\u00e9dicaments pour traiter les patients Covid.<\/p>\n

Deux de ces m\u00e9dicaments d\u00e9velopp\u00e9s en Isra\u00ebl se sont r\u00e9v\u00e9l\u00e9s tr\u00e8s prometteurs lors des essais cliniques: EXO-CD24 et Allocetra.<\/p>\n

EXO-CD24, un m\u00e9dicament exp\u00e9rimental sous forme d’inhalation d\u00e9velopp\u00e9 au Tel Aviv Sourasky Medical Center, a permis de gu\u00e9rir les 30 cas mod\u00e9r\u00e9s \u00e0 s\u00e9v\u00e8res lors un essai clinique de phase I.<\/p>\n

D\u00e9velopp\u00e9 au cours des six derniers mois \u00e0 l’h\u00f4pital, EXOCD24 arr\u00eate la \u00abtemp\u00eate de cytokines\u00bb – moment o\u00f9 le syst\u00e8me immunitaire devient incontr\u00f4lable et commence \u00e0 attaquer les cellules saines – qui se produit dans les poumons de 5 \u00e0 7% des patients atteints de Covid-19.<\/p>\n

\u00ab\u00c0 ce jour, la pr\u00e9paration a \u00e9t\u00e9 test\u00e9e avec beaucoup de succ\u00e8s sur 30 patients s\u00e9v\u00e8res, chez 29 d’entre eux, l’\u00e9tat de sant\u00e9 s’est am\u00e9lior\u00e9 en deux \u00e0 trois jours et la plupart d’entre eux ont \u00e9t\u00e9 renvoy\u00e9s chez eux sous trois \u00e0 cinq jours. Le 30e patient s’est \u00e9galement r\u00e9tabli, mais apr\u00e8s un plus long d\u00e9lai<\/em>\u00bb, a rapport\u00e9 l’h\u00f4pital.<\/p>\n

\u00abLe m\u00e9dicament est bas\u00e9 sur des exosomes, [v\u00e9sicules] qui sont lib\u00e9r\u00e9s de la membrane cellulaire et utilis\u00e9s pour la communication intercellulaire. Nous enrichissons les exosomes avec la prot\u00e9ine 24CD. Cette prot\u00e9ine est exprim\u00e9e \u00e0 la surface de la cellule et a un r\u00f4le connu et important dans la r\u00e9gulation du syst\u00e8me immunitaire<\/em> \u00bb, a expliqu\u00e9 le Dr Shiran Shapira, Directrice du laboratoire du Professeur Nadir Arber, qui \u00e9tudie la prot\u00e9ine CD24 depuis plus de deux d\u00e9cennies.<\/p>\n

\u00abLa pr\u00e9paration est administr\u00e9e par inhalation, une fois par jour, pendant seulement quelques minutes, pendant cinq jours\u00bb<\/em>, a d\u00e9clar\u00e9 Shapira.<\/p>\n

Elle a d\u00e9clar\u00e9 que le traitement exp\u00e9rimental avait deux caract\u00e9ristiques uniques. La premi\u00e8re est qu’il inhibe la s\u00e9cr\u00e9tion excessive de cytokines. La seconde est qu’il est administr\u00e9 directement aux poumons et n’a donc aucun des effets secondaires syst\u00e9miques que les m\u00e9dicaments inject\u00e9s ou oraux peuvent causer.<\/p>\n

\u00abM\u00eame si les vaccins remplissent leur fonction, et m\u00eame si aucune nouvelle mutation n\u2019est produite, d\u2019une mani\u00e8re ou d\u2019une autre, le corona restera avec nous<\/em>\u00bb, a d\u00e9clar\u00e9 Arber, Directeur du Centre int\u00e9gr\u00e9 de pr\u00e9vention du cancer du centre m\u00e9dical. \u00ab\u00c0 cette fin, nous avons d\u00e9velopp\u00e9 un m\u00e9dicament unique, EXO-CD24<\/em>.\u00bb<\/p>\n

Arber a ajout\u00e9 que cette pr\u00e9paration avanc\u00e9e pouvait \u00ab\u00a0\u00eatre produite rapidement et efficacement et \u00e0 un co\u00fbt tr\u00e8s bas dans toutes les installations pharmaceutiques du pays, et en peu de temps \u00e0 travers le monde<\/em>.\u00a0\u00bb<\/p>\n

Le Professeur Ronni Gamzu, PDG du centre m\u00e9dical, a d\u00e9clar\u00e9: \u00abLes r\u00e9sultats du Professeur Arber pour la recherche de la premi\u00e8re phase \u00e9taient excellents et nous ont tous donn\u00e9 confiance dans la m\u00e9thode qu\u2019il recherche [ici] depuis de nombreuses ann\u00e9es. Je l’ai personnellement aid\u00e9 \u00e0 obtenir les approbations du minist\u00e8re de la Sant\u00e9 pour des recherches plus pouss\u00e9es<\/em>\u00ab\u00a0.<\/p>\n

Pendant ce temps, Enlivex Therapeutics a rapport\u00e9 la semaine derni\u00e8re les r\u00e9sultats positifs d’un essai clinique multicentrique de phase II de son m\u00e9dicament d’immunoth\u00e9rapie exp\u00e9rimentale Covid-19 Allocetra chez des patients graves et critiques atteints de Covid-19.<\/p>\n

Nous avons rapport\u00e9 en octobre que cinq patients de soins intensifs atteints de Covid-19 \u00e9taient sortis du centre m\u00e9dical de l’universit\u00e9 Hadassah \u00e0 J\u00e9rusalem apr\u00e8s un traitement avec Allocetra.<\/p>\n

Neuf patients s\u00e9v\u00e8res et sept cas critiques de Covid-19 ont \u00e9t\u00e9 trait\u00e9s par Allocetra dans le cadre de l’essai clinique de phase II. Quatorze d’entre eux se sont r\u00e9tablis et sont sortis de l’h\u00f4pital apr\u00e8s une moyenne de 5,3 jours.<\/p>\n

L’essai de phase II devait initialement recruter 24 patients, mais a \u00e9t\u00e9 \u00abachev\u00e9 t\u00f4t pour soutenir les d\u00e9p\u00f4ts r\u00e9glementaires acc\u00e9l\u00e9r\u00e9s anticip\u00e9s des donn\u00e9es positives de s\u00e9curit\u00e9 et d’efficacit\u00e9 de l’essai<\/em>\u00bb, a rapport\u00e9 Enlivex.<\/p>\n

Au total, 19 des 21 patients des essais Allocetra de phase II et de phase Ib se sont r\u00e9tablis et sont sortis de l’h\u00f4pital apr\u00e8s une moyenne de 5,6 jours. La plupart des patients des deux \u00e9tudes pr\u00e9sentaient des facteurs de risque pr\u00e9existants tels que le sexe masculin, l’ob\u00e9sit\u00e9 et l’hypertension.<\/p>\n

\u00abLes r\u00e9sultats que nous avons observ\u00e9s sur les 12 patients Covid-19 trait\u00e9s \u00e0 ce jour avec Allocetra sont tr\u00e8s encourageants<\/em>\u00bb, a d\u00e9clar\u00e9 le Professeur Vernon van Heerden, chef de l’unit\u00e9 de soins intensifs g\u00e9n\u00e9raux \u00e0 Hadassah et chercheur principal des deux essais cliniques.<\/p>\n

\u00abLes patients de phase II qui sont sortis de l’h\u00f4pital sont actuellement en bonne sant\u00e9. Nous pensons que ces r\u00e9sultats convaincants ont d\u00e9montr\u00e9 l’innocuit\u00e9 et l’efficacit\u00e9 d’Allocetra chez ces patients compliqu\u00e9s, soulignant le potentiel du produit candidat d’Enlivex \u00e0 b\u00e9n\u00e9ficier aux patients graves et critiques de Covid-19 ainsi qu’\u00e0 d’autres souffrant de temp\u00eates de cytokines et de dysfonctionnements d’organes dans diverses indications cliniques.<\/em> \u00bb<\/p>\n

Allocetra est bas\u00e9 sur les recherches du Directeur scientifique et m\u00e9dical d’Enlivex, le Dr Dror Mevorach, chef de la m\u00e9decine interne et de l’un des services de coronavirus d’Hadassah. Il fonctionne en r\u00e9tablissant l’\u00e9quilibre du syst\u00e8me immunitaire.<\/p>\n

Mevorach a d\u00e9clar\u00e9 qu’Allocetra \u00abpourrait avoir une utilit\u00e9 en tant que traitement s\u00fbr et efficace … quelle que soit la mutation sp\u00e9cifique du coronavirus qui a afflig\u00e9 les patients, et dans diff\u00e9rentes indications cliniques potentiellement mortelles et \u00e0 mortalit\u00e9 \u00e9lev\u00e9e avec des besoins m\u00e9dicaux non satisfaits \u00e9lev\u00e9s<\/em>.\u00a0\u00bb<\/p>\n

Un Merci particulier au Genesis Prize<\/a> pour leur g\u00e9n\u00e9reux soutien<\/em><\/i><\/p>\n

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Le m\u00e9dicament exp\u00e9rimental Covid a gu\u00e9ri 30 des 30 cas mod\u00e9r\u00e9s \u00e0 s\u00e9v\u00e8res dans le cadre de l’essai clinique de phase I \u00e0 l’h\u00f4pital isra\u00e9lien. Le deuxi\u00e8me nouveau m\u00e9dicament est \u00e9galement prometteur. Par Abigail Klein Leichman, ISRAEL21c Bien qu’\u00e9tant leader international en mati\u00e8re de vaccination contre le Covid-19, Isra\u00ebl a constat\u00e9 que le monde avait… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":366032,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[41155,28414],"tags":[37426,37424,28785,29798,29313,29783,28846],"class_list":["post-378722","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-combat-disrael-contre-le-covid-19","category-influence-israelienne","tag-coronavirus-fr","tag-epidemie","tag-hopital","tag-medecine","tag-recherche","tag-sante","tag-traitement"],"better_featured_image":{"id":366032,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1707,"file":"2020\/10\/shutterstock_1663041304-scaled.jpg","sizes":{"medium":{"file":"shutterstock_1663041304-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-300x200.jpg"},"large":{"file":"shutterstock_1663041304-1024x683.jpg","width":1024,"height":683,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-1024x683.jpg"},"thumbnail":{"file":"shutterstock_1663041304-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-150x150.jpg"},"medium_large":{"file":"shutterstock_1663041304-768x512.jpg","width":768,"height":512,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-768x512.jpg"},"1536x1536":{"file":"shutterstock_1663041304-1536x1024.jpg","width":1536,"height":1024,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-1536x1024.jpg"},"2048x2048":{"file":"shutterstock_1663041304-2048x1365.jpg","width":2048,"height":1365,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-2048x1365.jpg"},"uwi-full-width":{"file":"shutterstock_1663041304-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1663041304-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1663041304-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1663041304-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1663041304-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1663041304-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1663041304-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-250x170.jpg"},"uwi-email":{"file":"shutterstock_1663041304-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1663041304-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_1663041304-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_1663041304-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/10\/shutterstock_1663041304-1024x768.jpg"},"uwi-ipad-x2":{"file"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