{"id":375668,"date":"2021-01-12T10:41:55","date_gmt":"2021-01-12T07:41:55","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=375668"},"modified":"2021-01-12T15:47:28","modified_gmt":"2021-01-12T12:47:28","slug":"la-medecine-israelienne-en-route-vers-un-traitement-de-lautisme","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/la-medecine-israelienne-en-route-vers-un-traitement-de-lautisme\/","title":{"rendered":"La m\u00e9decine isra\u00e9lienne en route vers un traitement de l’autisme?"},"content":{"rendered":"

Les chercheurs isra\u00e9liens esp\u00e8rent que leurs d\u00e9couvertes g\u00e9n\u00e9tiques li\u00e9es au cervelet et \u00e0 l’autisme m\u00e8neront \u00e0 de nouvelles th\u00e9rapies \u00e0 l’avenir.<\/strong><\/em><\/p>\n

Par TPS<\/em><\/p>\n

Des scientifiques de l’Universit\u00e9 h\u00e9bra\u00efque de J\u00e9rusalem ont identifi\u00e9 une mutation g\u00e9n\u00e9tique associ\u00e9e \u00e0 l’autisme, offrant l’espoir de nouveaux traitements contre l’autisme.<\/p>\n

Ces derni\u00e8res ann\u00e9es, des recherches substantielles ont permis de d\u00e9couvrir l’effet des mutations g\u00e9n\u00e9tiques sur le d\u00e9veloppement de l’autisme et d’autres troubles neurod\u00e9veloppementaux.<\/p>\n

Sur la base de ces \u00e9tudes, les chercheurs ont concentr\u00e9 leur attention sur les points communs derri\u00e8re ces mutations et leur impact sur le fonctionnement du cerveau.<\/p>\n

Une \u00e9tude men\u00e9e par le professeur Sagiv Shifman du Life Sciences Institute de l’Universit\u00e9 h\u00e9bra\u00efque de J\u00e9rusalem et du Center for Autism Research a r\u00e9v\u00e9l\u00e9 que les g\u00e8nes associ\u00e9s \u00e0 l’autisme avaient tendance \u00e0 \u00eatre impliqu\u00e9s dans la r\u00e9gulation d’autres g\u00e8nes et \u00e0 op\u00e9rer pr\u00e9f\u00e9rentiellement dans trois zones du cerveau. : le cortex, le striatum et le cervelet.<\/p>\n

Le cervelet est responsable de la fonction motrice, et des d\u00e9couvertes r\u00e9centes ont indiqu\u00e9 qu’il contribuait \u00e9galement au d\u00e9veloppement de nombreuses fonctions sociales et cognitives. Sur la base de ces r\u00e9sultats, l’\u00e9quipe de recherche esp\u00e8re que cela pourra conduire \u00e0 une meilleure compr\u00e9hension de la relation entre le cervelet et l’autisme et m\u00eame conduire \u00e0 de nouvelles th\u00e9rapies \u00e0 l’avenir.<\/p>\n

L’\u00e9tude de recherche publi\u00e9e dans Nature Communications a test\u00e9 l’un des g\u00e8nes les plus importants associ\u00e9s \u00e0 l’autisme, le g\u00e8ne Pogz.<\/p>\n

Shifman a choisi ce g\u00e8ne sp\u00e9cifique sur la base de d\u00e9couvertes ant\u00e9rieures qui le lient \u00e0 des troubles du d\u00e9veloppement et \u00e0 un comportement trop amical chez certains patients autistes.<\/p>\n

En partenariat avec le professeur Yosef Yarom du Centre Edmond & Lily Safra pour les sciences du cerveau de l’Universit\u00e9 h\u00e9bra\u00efque et d’autres laboratoires du monde entier, l’\u00e9quipe de recherche a \u00e9tudi\u00e9 l’impact d’une mutation du g\u00e8ne Pogz sur le d\u00e9veloppement du cerveau chez la souris et plus particuli\u00e8rement sur le fonctionnement du cervelet.<\/p>\n

Les r\u00e9sultats ont conclu que la mutation entra\u00eenait un comportement hyper-social, des troubles d’apprentissage tout en ayant \u00e9galement un impact sur le d\u00e9veloppement physique des souris.<\/p>\n

Apr\u00e8s une enqu\u00eate plus approfondie, l’\u00e9quipe de recherche a \u00e9galement observ\u00e9 que la mutation g\u00e9n\u00e9tique affectait la prolif\u00e9ration des cellules dans le cerveau et inhibait la production de nouveaux neurones. Les chercheurs pensent que cela peut \u00eatre une raison pour laquelle certains enfants porteurs de la mutation pr\u00e9sentent des tailles de t\u00eate plus petites que la moyenne.<\/p>\n

Bien qu’il n’existe actuellement aucun m\u00e9dicament efficace pour les principaux sympt\u00f4mes de l’autisme, le professeur Yarom estime que cette recherche pourrait contribuer au d\u00e9veloppement de m\u00e9dicaments visant \u00e0 modifier directement les processus neuronaux dans le cervelet.<\/p>\n

Des recherches ant\u00e9rieures men\u00e9es par le professeur Yarom ont montr\u00e9 que des agents chimiques sp\u00e9cifiques pouvaient modifier le fonctionnement actif du cervelet. Les recherches en cours seront donc ax\u00e9es sur la question de savoir si des approches similaires pourraient conduire les souris de laboratoire \u00e0 modifier leur comportement et inverser les effets li\u00e9s \u00e0 la mutation.<\/p>\n

\u00abNotre travail avec ce g\u00e8ne sp\u00e9cifique dont nous savons qu’il est li\u00e9 \u00e0 l’autisme et a un impact significatif sur le fonctionnement du cerveau nous donne un espoir consid\u00e9rable de pouvoir d\u00e9velopper des m\u00e9dicaments pour aider les enfants autistes<\/em>\u00bb, a d\u00e9clar\u00e9 le professeur Shifman.<\/p>\n

Le professeur Yarom a ajout\u00e9 \u00abune meilleure compr\u00e9hension des processus neurologiques derri\u00e8re l’autisme ouvre des possibilit\u00e9s pleines d’espoir pour de nouveaux traitements<\/em>\u00bb.<\/p>\n

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Les chercheurs isra\u00e9liens esp\u00e8rent que leurs d\u00e9couvertes g\u00e9n\u00e9tiques li\u00e9es au cervelet et \u00e0 l’autisme m\u00e8neront \u00e0 de nouvelles th\u00e9rapies \u00e0 l’avenir. Par TPS Des scientifiques de l’Universit\u00e9 h\u00e9bra\u00efque de J\u00e9rusalem ont identifi\u00e9 une mutation g\u00e9n\u00e9tique associ\u00e9e \u00e0 l’autisme, offrant l’espoir de nouveaux traitements contre l’autisme. Ces derni\u00e8res ann\u00e9es, des recherches substantielles ont permis de d\u00e9couvrir… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":333919,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[36793,40394,29798,29313,29783,28846],"class_list":["post-375668","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-autisme","tag-genetique","tag-medecine","tag-recherche","tag-sante","tag-traitement"],"better_featured_image":{"id":333919,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1707,"file":"2020\/02\/shutterstock_793837207-scaled.jpg","sizes":{"medium":{"file":"shutterstock_793837207-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-300x200.jpg"},"large":{"file":"shutterstock_793837207-1024x683.jpg","width":1024,"height":683,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-1024x683.jpg"},"thumbnail":{"file":"shutterstock_793837207-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-150x150.jpg"},"medium_large":{"file":"shutterstock_793837207-768x512.jpg","width":768,"height":512,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-768x512.jpg"},"1536x1536":{"file":"shutterstock_793837207-1536x1024.jpg","width":1536,"height":1024,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-1536x1024.jpg"},"2048x2048":{"file":"shutterstock_793837207-2048x1365.jpg","width":2048,"height":1365,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-2048x1365.jpg"},"uwi-full-width":{"file":"shutterstock_793837207-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_793837207-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_793837207-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_793837207-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_793837207-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_793837207-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_793837207-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-250x170.jpg"},"uwi-email":{"file":"shutterstock_793837207-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_793837207-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_793837207-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_793837207-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/02\/shutterstock_793837207-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_793837207-2048x1536.jpg","width":2048,"height":1536,"mime-type":"image\/jpeg","source_url":"htt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