{"id":370633,"date":"2020-11-25T20:52:50","date_gmt":"2020-11-25T17:52:50","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=370633"},"modified":"2020-11-26T10:44:53","modified_gmt":"2020-11-26T07:44:53","slug":"israel-invente-une-pilule-dinsuline-pour-revolutionner-le-quotidien-des-diabetiques","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/israel-invente-une-pilule-dinsuline-pour-revolutionner-le-quotidien-des-diabetiques\/","title":{"rendered":"Isra\u00ebl invente une pilule d’insuline pour r\u00e9volutionner le quotidien des diab\u00e9tiques"},"content":{"rendered":"

Une capsule d’insuline orale d\u00e9velopp\u00e9e par une soci\u00e9t\u00e9 isra\u00e9lienne est sur le point de commencer les derniers essais, ouvrant la voie au premier traitement efficace du diab\u00e8te sans injections.<\/em><\/strong><\/p>\n

Par l’\u00e9quipe d’Unis avec Isra\u00ebl<\/em><\/p>\n

Les personnes qui souffrent de diab\u00e8te ont souvent besoin d’injections d’insuline, ce qui provoque des douleurs, des inconv\u00e9nients et des cicatrices visibles qui ne disparaissent pas. Pour r\u00e9soudre ce probl\u00e8me de sant\u00e9 urgent, une soci\u00e9t\u00e9 bas\u00e9e en Isra\u00ebl a d\u00e9velopp\u00e9 la premi\u00e8re capsule d’insuline orale, appel\u00e9e ORMD-0801, permettant un traitement du diab\u00e8te sans injection.<\/p>\n

La pilule a pass\u00e9 avec succ\u00e8s les s\u00e9ries de tests pr\u00e9c\u00e9dentes avec des r\u00e9sultats impressionnants, la pla\u00e7ant sur la voie rapide pour une disponibilit\u00e9 commerciale, a annonc\u00e9 Oramed au printemps dernier.<\/p>\n

Pr\u00e8s d’un demi-milliard de personnes dans le monde souffrent de diab\u00e8te.<\/p>\n

Lundi, ORMD-0801 a d\u00e9but\u00e9 les tests de la phase finale, marquant le point culminant de pr\u00e8s d’une d\u00e9cennie et demie de d\u00e9veloppement.<\/p>\n

Si la Food and Drug Administration (FDA) des \u00c9tats-Unis approuve finalement le m\u00e9dicament, les diab\u00e9tiques de type 2 pourront commencer \u00e0 prendre des pilules d’insuline dans un peu plus de trois ans, les diab\u00e9tiques de type 1 ne seront autoris\u00e9s \u00e0 l’utiliser apr\u00e8s des tests plus pouss\u00e9s.<\/p>\n

Lors de sa pr\u00e9c\u00e9dente s\u00e9rie de tests, Oramed a r\u00e9alis\u00e9 des tests de dosage randomis\u00e9s, contr\u00f4l\u00e9s par placebo, en double aveugle, sur 90 jours. Cinquante-sept patients aux \u00c9tats-Unis souffrant de diab\u00e8te de type 2 avec un contr\u00f4le glyc\u00e9mique inad\u00e9quat ont termin\u00e9 l’essai de 12 semaines.<\/p>\n

\u00ab\u00a0Le traitement par ORMD-0801 \u00e0 toutes les doses a d\u00e9montr\u00e9 un excellent profil de s\u00e9curit\u00e9, sans \u00e9v\u00e9nements ind\u00e9sirables graves li\u00e9s au m\u00e9dicament et sans augmentation de la fr\u00e9quence des \u00e9pisodes hypoglyc\u00e9miques ou du gain de poids par rapport au placebo\u00a0\u00bb<\/em>, a d\u00e9clar\u00e9 une soci\u00e9t\u00e9 dans un communiqu\u00e9.<\/p>\n

Le PDG d’Oramed, Nadav Kidron, a d\u00e9clar\u00e9: \u00abNous pensons que la forte efficacit\u00e9 d\u00e9montr\u00e9e lors du traitement des patients \u00e0 une dose plus faible prouve encore le potentiel de l’ORMD-0801 en tant que solution d’insuline orale s\u00fbre, non invasive et efficace pour les millions de personnes souffrant de diab\u00e8te dans le monde<\/em>. \u00a0\u00bb<\/p>\n

Joel M. Neutel, MD, l’investigateur principal de l’essai ORMD-0801 Phase 2b, a comment\u00e9: \u00abJe crois que les donn\u00e9es d\u00e9montr\u00e9es dans cette deuxi\u00e8me cohorte valident davantage le potentiel clinique de l’insuline orale d’Oramed comme ayant un impact tr\u00e8s b\u00e9n\u00e9fique sur le traitement de diab\u00e8te dans le monde entier.<\/em> \u00bb<\/p>\n

Oramed a d\u00e9j\u00e0 d\u00e9velopp\u00e9 une nouvelle technologie d’administration orale de prot\u00e9ines bas\u00e9e sur plus de 30 ans de recherche par des scientifiques du centre m\u00e9dical Hadassah de J\u00e9rusalem. Cette innovation s’est bien int\u00e9gr\u00e9e dans la capsule d’insuline orale.<\/p>\n

\u00ab\u00a0Depuis que l’insuline a \u00e9t\u00e9 d\u00e9couverte pour la premi\u00e8re fois, il a \u00e9t\u00e9 impossible de l’administrer par voie orale, en raison de la d\u00e9gradation et des facteurs affectant l’absorbance; l’insuline \u00e9tant une prot\u00e9ine, le corps la d\u00e9compose lorsqu’elle est ing\u00e9r\u00e9e<\/em>\u00ab\u00a0, a rapport\u00e9 Forbes au printemps. \u00abLa soci\u00e9t\u00e9 utilise un enrobage ent\u00e9rique et une protection sp\u00e9ciale qui permettent \u00e0 l’insuline de rester intacte \u00e0 travers le tractus gastro-intestinal et d’atteindre la paroi intestinale. Gr\u00e2ce \u00e0 des amplificateurs d’absorption sp\u00e9ciaux, l’insuline peut traverser cette paroi et p\u00e9n\u00e9trer dans le foie, o\u00f9 elle commence \u00e0 agir. il imite le chemin naturel de l’insuline dans le corps, en se dirigeant d’abord vers le foie.<\/em> \u00a0\u00bb<\/p>\n

La cr\u00e9ation de cette capsule d’insuline n’aurait pas pu arriver \u00e0 un moment plus opportun, le Washington Post rapportant l’ann\u00e9e derni\u00e8re que la hausse des co\u00fbts de l’insuline a contraint certains diab\u00e9tiques \u00e0 rationner leur traitement, mettant leur vie en danger.<\/p>\n

Kidron a d\u00e9clar\u00e9 \u00eatre \u00ab\u00a0convaincu que le co\u00fbt de la pilule sera nettement inf\u00e9rieur (de dizaines de pourcents) au co\u00fbt des injections d’insuline\u00a0\u00bb,<\/em> a rapport\u00e9 Forbes.<\/p>\n

Alors qu’une soci\u00e9t\u00e9 indienne appel\u00e9e Biocon travaille \u00e9galement sur une formulation d’insuline orale, son produit n’a pas encore commenc\u00e9 les essais avanc\u00e9s de la FDA.<\/p>\n

Do You Love Israel? Make a Donation - Show Your Support!<\/h2>
\"\"<\/a>

<\/p><\/div>

Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p>

Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p>

Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. Help us fight back!<\/strong><\/a> <\/p>

STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode>

\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"

Une capsule d’insuline orale d\u00e9velopp\u00e9e par une soci\u00e9t\u00e9 isra\u00e9lienne est sur le point de commencer les derniers essais, ouvrant la voie au premier traitement efficace du diab\u00e8te sans injections. Par l’\u00e9quipe d’Unis avec Isra\u00ebl Les personnes qui souffrent de diab\u00e8te ont souvent besoin d’injections d’insuline, ce qui provoque des douleurs, des inconv\u00e9nients et des cicatrices… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":349144,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[35948,40124,29798,29313,29783],"class_list":["post-370633","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-diabete","tag-insuline","tag-medecine","tag-recherche","tag-sante"],"better_featured_image":{"id":349144,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":1706,"file":"2020\/05\/shutterstock_1669906138-scaled.jpg","sizes":{"medium":{"file":"shutterstock_1669906138-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-300x200.jpg"},"large":{"file":"shutterstock_1669906138-1024x683.jpg","width":1024,"height":683,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-1024x683.jpg"},"thumbnail":{"file":"shutterstock_1669906138-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-150x150.jpg"},"medium_large":{"file":"shutterstock_1669906138-768x512.jpg","width":768,"height":512,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-768x512.jpg"},"1536x1536":{"file":"shutterstock_1669906138-1536x1024.jpg","width":1536,"height":1024,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-1536x1024.jpg"},"2048x2048":{"file":"shutterstock_1669906138-2048x1365.jpg","width":2048,"height":1365,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-2048x1365.jpg"},"uwi-full-width":{"file":"shutterstock_1669906138-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1669906138-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1669906138-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1669906138-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1669906138-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1669906138-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1669906138-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-250x170.jpg"},"uwi-email":{"file":"shutterstock_1669906138-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1669906138-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_1669906138-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_1669906138-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_1669906138-2048x1536.jpg","width":2048,"height":1536,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-2048x1536.jpg"},"uwi-full-width-video":{"file":"shutterstock_1669906138-779x519.jpg","width":779,"height":519,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-779x519.jpg"},"uwi-fb-share-video":{"file":"shutterstock_1669906138-600x315.jpg","width":600,"height":315,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-600x315.jpg"},"uwi-fb-share":{"file":"shutterstock_1669906138-600x320.jpg","width":600,"height":320,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-600x320.jpg"},"uwi-featured-content-video":{"file":"shutterstock_1669906138-289x159.jpg","width":289,"height":159,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-289x159.jpg"},"uwi-content-loop-video":{"file":"shutterstock_1669906138-189x189.jpg","width":189,"height":189,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-189x189.jpg"},"uwi-category_list-video":{"file":"shutterstock_1669906138-179x99.jpg","width":179,"height":99,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-179x99.jpg"},"uwi-tiny-video":{"file":"shutterstock_1669906138-39x39.jpg","width":39,"height":39,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-39x39.jpg"},"uwi-email-featured-video":{"file":"shutterstock_1669906138-249x169.jpg","width":249,"height":169,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-249x169.jpg"},"uwi-email-video":{"file":"shutterstock_1669906138-209x139.jpg","width":209,"height":139,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-209x139.jpg"},"uwi-iphone-video":{"file":"shutterstock_1669906138-959x639.jpg","width":959,"height":639,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-959x639.jpg"},"uwi-iphone-x2-video":{"file":"shutterstock_1669906138-1135x639.jpg","width":1135,"height":639,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-1135x639.jpg"},"uwi-ipad-video":{"file":"shutterstock_1669906138-1123x767.jpg","width":1123,"height":767,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-1123x767.jpg"},"uwi-ipad-x2-video":{"file":"shutterstock_1669906138-2047x1535.jpg","width":2047,"height":1535,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-2047x1535.jpg"},"post-thumbnail":{"file":"shutterstock_1669906138-125x125.jpg","width":125,"height":125,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-125x125.jpg"}},"image_meta":{"aperture":"0","credit":"","camera":"","caption":"","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"","orientation":"1","keywords":[]},"original_image":"shutterstock_1669906138.jpg"},"post":349143,"source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/05\/shutterstock_1669906138-scaled.jpg"},"aioseo_notices":[],"distributor_meta":false,"distributor_terms":false,"distributor_media":false,"distributor_original_site_name":"Unis avec Isra\u00ebl","distributor_original_site_url":"https:\/\/kinsta.unitedwithisrael.org\/fr\/","push-errors":false,"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts\/370633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/users\/4242"}],"replies":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/comments?post=370633"}],"version-history":[{"count":0,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/posts\/370633\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/media\/349144"}],"wp:attachment":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/media?parent=370633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/categories?post=370633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/fr\/wp-json\/wp\/v2\/tags?post=370633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}