{"id":370416,"date":"2020-11-23T19:44:52","date_gmt":"2020-11-23T16:44:52","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=370416"},"modified":"2020-11-24T13:17:30","modified_gmt":"2020-11-24T10:17:30","slug":"une-technologie-israelienne-revolutionnaire-tue-les-cellules-cancereuses","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/une-technologie-israelienne-revolutionnaire-tue-les-cellules-cancereuses\/","title":{"rendered":"Une technologie isra\u00e9lienne r\u00e9volutionnaire tue les cellules canc\u00e9reuses"},"content":{"rendered":"

Les chercheurs de l’Universit\u00e9 de Tel Aviv combinent la nanotechnologie et le syst\u00e8me d’\u00e9dition du g\u00e9nome CRISPR pour d\u00e9truire les cellules canc\u00e9reuses m\u00e9tastatiques.<\/strong><\/em><\/p>\n

Par Yakir Benzion, Unis avec Isra\u00ebl<\/em><\/p>\n

Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9montr\u00e9 que la m\u00e9thode CRISPR d’\u00e9dition de g\u00e8nes se r\u00e9velait tr\u00e8s efficace dans le traitement des cancers m\u00e9tastatiques, une \u00e9tape importante sur la voie de la recherche d’un rem\u00e8de contre le cancer.<\/p>\n

\u00abIl s’agit de la premi\u00e8re \u00e9tude au monde qui prouve que le syst\u00e8me d’\u00e9dition du g\u00e9nome CRISPR peut \u00eatre utilis\u00e9 pour traiter efficacement le cancer chez un animal vivant\u00bb<\/em>, a d\u00e9clar\u00e9 le professeur Dan Peer qui supervise le programme de recherche.<\/p>\n

\u00abIl faut souligner qu’il ne s’agit pas de chimioth\u00e9rapie. Il n’y a pas d’effets secondaires et une cellule canc\u00e9reuse trait\u00e9e de cette mani\u00e8re ne redeviendra jamais active \u00bb<\/em>, a d\u00e9clar\u00e9 Peer.<\/p>\n

Les chercheurs isra\u00e9liens utilisent CRISPR, qui signifie Clustered Regularly Interspaced Short Palindromic Repeats, une technologie r\u00e9volutionnaire qui peut modifier les g\u00e8nes et, selon les termes du New Scientist Magazine, \u00ab\u00a0changera probablement le monde<\/em>\u00ab\u00a0.<\/p>\n

\u00abL\u2019essence de CRISPR est simple: c\u2019est un moyen de trouver un morceau d\u2019ADN sp\u00e9cifique \u00e0 l\u2019int\u00e9rieur d\u2019une cellule. Apr\u00e8s cela, la prochaine \u00e9tape de l\u2019\u00e9dition du g\u00e8ne CRISPR consiste g\u00e9n\u00e9ralement \u00e0 modifier ce morceau d\u2019ADN<\/em>\u00bb, explique le magazine.<\/p>\n

Les chercheurs de Tel Aviv se sont attaqu\u00e9s au cancer le plus agressif, connu sous le nom de cancer m\u00e9tastatique. C’est le type de cancer dans lequel les cellules canc\u00e9reuses se d\u00e9tachent de l’endroit o\u00f9 elles se sont form\u00e9es pour cr\u00e9er de nouvelles tumeurs – des tumeurs m\u00e9tastatiques – dans d’autres parties du corps. Il s’agit du stade le plus mortel du cancer, \u00e9galement appel\u00e9 cancer de stade 4.<\/p>\n

\u00ab\u00a0La technologie sur laquelle notre syst\u00e8me est bas\u00e9, la technologie d’\u00e9dition du g\u00e9nome CRISPR, nous permet de modifier et de perturber fondamentalement tout g\u00e8ne d’int\u00e9r\u00eat dans n’importe quel type de cellule que nous voulons\u00a0\u00bb,<\/em> a d\u00e9clar\u00e9 le Dr Daniel Rosenblum, du Laboratoire de nanom\u00e9decine de pr\u00e9cision de TAU. \u00ab\u00a0Cela nous permet fondamentalement de modifier et de perturber n’importe quel g\u00e8ne d’int\u00e9r\u00eat dans n’importe quel type de cellule que nous voulons donc les possibilit\u00e9s sont fondamentalement infinies<\/em>.\u00a0\u00bb<\/p>\n

Le professeur Peer explique que l’\u00e9quipe a cr\u00e9\u00e9 une strat\u00e9gie pour cibler les cellules canc\u00e9reuses d’une mani\u00e8re tr\u00e8s sp\u00e9cifique, \u00abd\u00e9livrant un ARN messager qui code pour une prot\u00e9ine qui coupe l’ADN<\/em>\u00bb des cellules canc\u00e9reuses.<\/p>\n

Selon l’\u00e9tude, le traitement par CRISPR-LNP dans un cancer de l’ovaire m\u00e9tastatique chez des souris de laboratoire a augment\u00e9 leur taux de survie global de 80%.<\/p>\n

L’\u00e9tudiante au doctorat Anna Gutkin a d\u00e9clar\u00e9 que l’\u00e9quipe s’\u00e9tait concentr\u00e9e sur les deux des types de cancer les plus agressifs.<\/p>\n

\u00ab\u00a0Nous croyons vraiment que nous pouvons traiter non seulement ces maladies, mais ouvrir de nouvelles voies pour de nouvelles th\u00e9rapies pour d’autres cancers et d’autres maladies g\u00e9n\u00e9tiques.<\/em>\u00a0\u00bb<\/p>\n

Peer explique que sur plus de 500 types de cancer diff\u00e9rents, certains ont des caract\u00e9ristiques g\u00e9n\u00e9tiques uniques, et la technologie du laboratoire de Tel Aviv est utilis\u00e9e pour cibler ces cancers sp\u00e9cifiques.<\/p>\n

\u00ab\u00a0Cela pourrait \u00eatre des cancers du sang sp\u00e9cifiques, des tumeurs c\u00e9r\u00e9brales de gliome et des cancers de l’ovaire qui ont d\u00e9j\u00e0 m\u00e9tastas\u00e9\u00a0\u00bb,<\/em> a d\u00e9clar\u00e9 Peer.<\/p>\n

\u00ab\u00a0Nous pensons qu’un seul traitement ou peut-\u00eatre deux ou trois traitements, mais pas plus, seront probablement suffisamment efficaces pour prolonger la survie, mais aussi am\u00e9liorer la qualit\u00e9 de vie.\u00a0\u00bb<\/em><\/p>\n

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Les chercheurs de l’Universit\u00e9 de Tel Aviv combinent la nanotechnologie et le syst\u00e8me d’\u00e9dition du g\u00e9nome CRISPR pour d\u00e9truire les cellules canc\u00e9reuses m\u00e9tastatiques. Par Yakir Benzion, Unis avec Isra\u00ebl Des chercheurs de l’Universit\u00e9 de Tel Aviv ont d\u00e9montr\u00e9 que la m\u00e9thode CRISPR d’\u00e9dition de g\u00e8nes se r\u00e9velait tr\u00e8s efficace dans le traitement des cancers m\u00e9tastatiques,… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":266266,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[33896,30152,29798,29313,29783,33266,28846],"class_list":["post-370416","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-cancer-fr","tag-chercheurs","tag-medecine","tag-recherche","tag-sante","tag-tel-aviv-fr","tag-traitement"],"better_featured_image":{"id":266266,"alt_text":"Cancer immunotherapy research","caption":"Cancer immunotherapy research with cell and test tube. 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