{"id":357236,"date":"2020-07-21T17:54:16","date_gmt":"2020-07-21T14:54:16","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=357236"},"modified":"2020-07-22T11:13:01","modified_gmt":"2020-07-22T08:13:01","slug":"israel-pourra-bientot-traiter-les-cancers-parkinson-et-alzheimer-par-ultrasons","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/israel-pourra-bientot-traiter-les-cancers-parkinson-et-alzheimer-par-ultrasons\/","title":{"rendered":"Isra\u00ebl pourra bient\u00f4t traiter les cancers, Parkinson et Alzheimer par ultrasons"},"content":{"rendered":"

Une technique r\u00e9volutionnaire bas\u00e9e sur les ultrasons et mise au point \u00e0 l\u2019Universit\u00e9 de Tel Aviv pour traiter le cancer pourrait s\u2019appliquer \u00e0 la maladie de Parkinson, \u00e0 la maladie d\u2019Alzheimer et \u00e0 d\u2019autres maladies.<\/strong><\/em><\/p>\n

Par Yakir Benzion, Unis avec Isra\u00ebl<\/em><\/p>\n

Une \u00e9quipe de recherche bas\u00e9e \u00e0 Tel Aviv a d\u00e9velopp\u00e9 une m\u00e9thode pour lutter contre le cancer en projetant des microbulles sur les cellules canc\u00e9reuses, puis en les faisant exploser \u00e0 l’aide d’ultrasons.<\/p>\n

Les microbulles explosent comme des ogives intelligentes cibl\u00e9es, cr\u00e9ant des trous dans les membranes des cellules canc\u00e9reuses et permettant l’administration de la th\u00e9rapie g\u00e9nique, avec des tests faisant \u00e9tat de jusqu’\u00e0 80% des cellules tumorales tu\u00e9es.<\/p>\n

La technique appara\u00eet tr\u00e8s simple et prometteuse, mais des quantit\u00e9s incroyables de science et de travail acharn\u00e9 se cachent derri\u00e8re, a affirm\u00e9 le Dr Tali Ilovitsh du d\u00e9partement de g\u00e9nie biom\u00e9dical de l’Universit\u00e9 de Tel Aviv.<\/p>\n

Les ultrasons ont, pendant des ann\u00e9es, \u00e9t\u00e9 utilis\u00e9s comme outils de diagnostic pour diff\u00e9rents cancers, mais le Dr Ilovitsh vient d\u00e9sormais de r\u00e9ussir \u00e0 s’en servir dans la lutte contre le \u00abgrand C\u00bb en les associant \u00e0 un \u00abcheval de Troie\u00bb de th\u00e9rapie g\u00e9nique.<\/p>\n

Elle a commenc\u00e9 la technologie de pointe lors de ses recherches postdoctorales \u00e0 l’Universit\u00e9 de Stanford et a poursuivi le travail chez elle \u00e0 Tel Aviv, en vue de trouver une m\u00e9thode qui fournirait un traitement de th\u00e9rapie g\u00e9nique directement dans les cellules canc\u00e9reuses du sein.<\/p>\n

\u00abLes microbulles sont des bulles microscopiques remplies de gaz, d’un diam\u00e8tre aussi petit qu’un dixi\u00e8me de vaisseau sanguin\u00bb<\/em>, explique le Dr Ilovitsh.<\/p>\n

\u00ab\u00a0A certaines fr\u00e9quences et pressions, les ondes sonores font agir les microbulles comme des ballons: elles se dilatent et se contractent p\u00e9riodiquement. Ce processus augmente le transfert de substances des vaisseaux sanguins vers les tissus environnants.<\/em>\u00a0\u00bb<\/p>\n

\u00abNous avons d\u00e9couvert qu’en utilisant des fr\u00e9quences [ultrasonores] inf\u00e9rieures \u00e0 celles appliqu\u00e9es pr\u00e9c\u00e9demment, les microbulles pouvaient se dilater de mani\u00e8re significative, jusqu’\u00e0 exploser violemment. Nous avons r\u00e9alis\u00e9 que cette d\u00e9couverte pouvait \u00eatre utilis\u00e9e comme plate-forme pour le traitement du cancer et avons commenc\u00e9 \u00e0 injecter directement des microbulles dans les tumeurs<\/em>\u00bb, a d\u00e9clar\u00e9 le Dr Dit Ilovitsh.<\/p>\n

Lors des exp\u00e9riences de laboratoire men\u00e9es sur des souris, \u00abenviron 80% des cellules tumorales ont \u00e9t\u00e9 d\u00e9truites dans l’explosion, ce qui \u00e9tait positif en soi\u00bb,<\/em> a-t-elle d\u00e9clar\u00e9, mais pas assez, car il est n\u00e9cessaire de d\u00e9truire toute la tumeur.<\/p>\n

\u00abAfin d’emp\u00eacher les cellules canc\u00e9reuses restantes de se propager … nous avons inject\u00e9 un g\u00e8ne d’immunoth\u00e9rapie aux c\u00f4t\u00e9s des microbulles, qui agit comme un cheval de Troie, et avons signal\u00e9 au syst\u00e8me immunitaire d’attaquer la cellule canc\u00e9reuse<\/em>\u00bb, a-t-elle d\u00e9clar\u00e9, expliquant que l’ajout de la th\u00e9rapie g\u00e9nique aux bulles leur permettait d’entrer directement dans les 20% restants du cancer \u00e0 travers de minuscules trous form\u00e9s par l’explosion des bulles.<\/p>\n

Une fois que le g\u00e8ne est \u00e0 l’int\u00e9rieur, il d\u00e9clenche une r\u00e9ponse immunitaire qui d\u00e9truit la cellule canc\u00e9reuse.<\/p>\n

\u00abLa majorit\u00e9 des cellules canc\u00e9reuses ont \u00e9t\u00e9 d\u00e9truites par l’explosion et les cellules restantes ont consomm\u00e9 le g\u00e8ne d’immunoth\u00e9rapie \u00e0 travers les trous cr\u00e9\u00e9s dans leurs membranes. Le g\u00e8ne a amen\u00e9 les cellules \u00e0 produire une substance qui a incit\u00e9 le syst\u00e8me immunitaire \u00e0 attaquer la cellule canc\u00e9reuse. En fait, nos souris avaient des tumeurs des deux c\u00f4t\u00e9s de leur corps. Malgr\u00e9 le fait que nous ayons effectu\u00e9 le traitement d’un seul c\u00f4t\u00e9, le syst\u00e8me immunitaire a \u00e9galement attaqu\u00e9 le c\u00f4t\u00e9 oppos\u00e9<\/em> \u00bb, a d\u00e9clar\u00e9 le Dr Ilovitsh.<\/p>\n

Non seulement le nouveau traitement cibl\u00e9 est s\u00fbr et rentable, mais il peut \u00e9galement \u00eatre utilis\u00e9 comme traitement non invasif pour les maladies c\u00e9r\u00e9brales telles que les tumeurs c\u00e9r\u00e9brales et d\u2019autres maladies neurod\u00e9g\u00e9n\u00e9ratives telles que la maladie d\u2019Alzheimer et de Parkinson.<\/p>\n

\u00abLa barri\u00e8re h\u00e9mato-enc\u00e9phalique ne permet pas aux m\u00e9dicaments de p\u00e9n\u00e9trer \u00e0 travers, mais les microbulles peuvent temporairement ouvrir la barri\u00e8re, permettant l’arriv\u00e9e du traitement dans la zone cible sans avoir besoin d’une intervention chirurgicale invasive<\/em>\u00bb, a-t-elle d\u00e9clar\u00e9.<\/p>\n

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Une technique r\u00e9volutionnaire bas\u00e9e sur les ultrasons et mise au point \u00e0 l\u2019Universit\u00e9 de Tel Aviv pour traiter le cancer pourrait s\u2019appliquer \u00e0 la maladie de Parkinson, \u00e0 la maladie d\u2019Alzheimer et \u00e0 d\u2019autres maladies. Par Yakir Benzion, Unis avec Isra\u00ebl Une \u00e9quipe de recherche bas\u00e9e \u00e0 Tel Aviv a d\u00e9velopp\u00e9 une m\u00e9thode pour lutter… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":298492,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[33896,34044,29313,34156,28846,39172],"class_list":["post-357236","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-cancer-fr","tag-decouverte","tag-recherche","tag-science-fr","tag-traitement","tag-ultrasons"],"better_featured_image":{"id":298492,"alt_text":"A researcher at the Technion Israel Institute of Technology in Haifa (Hadas Parush\/Flash90)","caption":"A researcher at the Technion Israel Institute of Technology in Haifa (Hadas Parush\/Flash90)","description":"Pesquisador no Instituto Technion na cidade de Haifa (Hadas 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