{"id":357019,"date":"2020-07-19T16:33:04","date_gmt":"2020-07-19T13:33:04","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=357019"},"modified":"2020-07-20T09:44:32","modified_gmt":"2020-07-20T06:44:32","slug":"israel-decouvre-une-methode-permettant-de-detecter-les-cellules-cancereuses-subsistant-dans-lorganisme-apres-operation","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/israel-decouvre-une-methode-permettant-de-detecter-les-cellules-cancereuses-subsistant-dans-lorganisme-apres-operation\/","title":{"rendered":"Isra\u00ebl d\u00e9couvre une m\u00e9thode permettant de d\u00e9tecter les cellules canc\u00e9reuses subsistant dans l’organisme apr\u00e8s op\u00e9ration"},"content":{"rendered":"

La m\u00e9thode isra\u00e9lienne r\u00e9duit consid\u00e9rablement le temps d’attente pour les r\u00e9sultats de laboratoire des tests de d\u00e9tection de cellules canc\u00e9reuses apr\u00e8s une intervention chirurgicale visant \u00e0 enlever une tumeur maligne dans l’abdomen.<\/strong><\/em><\/p>\n

Par ISRAEL21c<\/em><\/p>\n

Combinant la m\u00e9decine, l’ing\u00e9nierie et l’informatique, une nouvelle approche isra\u00e9lienne permet de d\u00e9tecter – en temps r\u00e9el – toutes les cellules canc\u00e9reuses laiss\u00e9es dans la cavit\u00e9 abdominale apr\u00e8s l’ablation chirurgicale d’une tumeur maligne.<\/p>\n

Cette perc\u00e9e vient d’une \u00e9quipe de recherche de l’Institut Zimin pour les solutions d’ing\u00e9nierie de l’Universit\u00e9 de Tel Aviv, Advancing Better Lives, dirig\u00e9e par le professeur Noam Shomron et le doctorant Artem Danilevsky.<\/p>\n

Shomron explique qu’il subsiste souvent des cellules canc\u00e9reuses non d\u00e9tect\u00e9es apr\u00e8s l’ablation de la tumeur. Ces cellules pouvant se propager dans tout le corps, le patient doit subir des traitements de chimioth\u00e9rapie pour les \u00e9liminer.<\/p>\n

Le probl\u00e8me est que le laps de temps critique entre la chirurgie et les r\u00e9sultats des tests de laboratoire de d\u00e9tection des cellules canc\u00e9reuses peut durer plusieurs semaines, un d\u00e9lai qui augmente consid\u00e9rablement le risque d’une nouvelle propagation du cancer.<\/p>\n

Le nouvel outil d\u00e9velopp\u00e9 par Shomron et Danilevsky est bas\u00e9 sur un dispositif de s\u00e9quen\u00e7age g\u00e9n\u00e9tique appel\u00e9 MinION, produit par Oxford Nanopore Technologies. MinION permet aux m\u00e9decins et aux patients de recevoir des r\u00e9sultats en quelques minutes \u00e0 plusieurs heures.<\/p>\n

Les chercheurs pr\u00e9l\u00e8vent un \u00e9chantillon de sang et de liquide dans la cavit\u00e9 abdominale pendant que le patient subit une chirurgie d’\u00e9limination de la tumeur. Les \u00e9chantillons sont ins\u00e9r\u00e9s dans l’appareil MinION, qui, \u00e0 l’aide d’un algorithme unique d\u00e9velopp\u00e9 par les chercheurs isra\u00e9liens, peut d\u00e9terminer si l’\u00e9chantillon ressemble plus \u00e0 celui d’une personne en bonne sant\u00e9 ou d’un patient atteint de cancer.<\/p>\n

Cette application simple mais intelligente d’une technologie existante a \u00e9t\u00e9 mise en \u0153uvre avec succ\u00e8s dans un programme pilote pr\u00e9liminaire au Tel Aviv Sourasky Medical Center (h\u00f4pital Ichilov).<\/p>\n

\u00ab\u00a0Nous attendons devant la salle d’op\u00e9ration du Dr Guy Lahat \u00e0 Ichilov. Au cours de la chirurgie, le Dr Shelly Loewenstein pr\u00e9l\u00e8ve une petite partie de l’\u00e9chantillon de liquide de la cavit\u00e9 abdominale pour nous. L’\u00e9chantillon lui-m\u00eame est envoy\u00e9 simultan\u00e9ment au test de laboratoire standard. Les r\u00e9sultats des tests de laboratoire arrivent apr\u00e8s quelques semaines. Pendant ce temps, nous ins\u00e9rons notre \u00e9chantillon dans le MinION et calculons s’il contient des cellules canc\u00e9reuses ou saines. C’est beaucoup moins compliqu\u00e9 que de s\u00e9quencer tout le g\u00e9nome<\/em> \u00bb, a d\u00e9clar\u00e9 Shomron.<\/p>\n

\u00abSi les r\u00e9sultats s’av\u00e8rent positifs, le Dr Lahat continue avec un traitement de chimioth\u00e9rapie d\u00e9sign\u00e9 pour la cavit\u00e9 abdominale. Ensuite, il effectue un lavage salin, prend un autre \u00e9chantillon et r\u00e9p\u00e8te le cycle \u00e0 nouveau, jusqu’\u00e0 ce que nous nous assurions que le patient est exempt de cellules canc\u00e9reuses.<\/em><\/p>\n

Il s’agit d’un traitement m\u00e9dical potentiellement vital\u00a0\u00bb,<\/em> a pr\u00e9dit Shomron.<\/p>\n

Les chercheurs soulignent cependant que la mise en \u0153uvre du nouvel appareil en est encore \u00e0 ses premiers stades d’essai et qu’il faut plus de temps pour que le nouvel appareil atteigne le niveau de pr\u00e9cision des appareils plus anciens, plus lents et plus grands.<\/p>\n

En outre, Shomron estime que dans plusieurs ann\u00e9es, il pourrait \u00eatre possible d’\u00e9tendre la mise en \u0153uvre de cette nouvelle technologie pour d\u00e9tecter les cellules canc\u00e9reuses avec un simple test sanguin au cours de la vie quotidienne et pas seulement lors d’une intervention chirurgicale.<\/p>\n

Il a expliqu\u00e9 que l’Institut Zimin recherchait une application d’ing\u00e9nierie pour am\u00e9liorer des vies.<\/p>\n

\u00abIls ont demand\u00e9 des projets nouveaux et uniques. Des projets qui ne recevraient de financement d’aucune autre fondation mais qui seront r\u00e9alisables. Nous avons combin\u00e9 plusieurs domaines de recherche afin d\u2019offrir un outil de diagnostic intelligent et rapide, mais il n\u2019y avait pas d\u2019acheteurs. Nous sommes pass\u00e9s par diff\u00e9rentes divisions hospitali\u00e8res et avons demand\u00e9 aux m\u00e9decins \u00abQui veut faire un test ADN en une heure?<\/em>\u00bb<\/p>\n

\u00abHeureusement, nous avons trouv\u00e9 le Dr Lahat, directeur de la division de chirurgie d’Ichilov, qui a saisi l’occasion de raccourcir et d’am\u00e9liorer les processus de diagnostic au profit des patients atteints de cancer.\u00a0\u00bb<\/em><\/p>\n

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\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"

La m\u00e9thode isra\u00e9lienne r\u00e9duit consid\u00e9rablement le temps d’attente pour les r\u00e9sultats de laboratoire des tests de d\u00e9tection de cellules canc\u00e9reuses apr\u00e8s une intervention chirurgicale visant \u00e0 enlever une tumeur maligne dans l’abdomen. Par ISRAEL21c Combinant la m\u00e9decine, l’ing\u00e9nierie et l’informatique, une nouvelle approche isra\u00e9lienne permet de d\u00e9tecter – en temps r\u00e9el – toutes les cellules… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":298492,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28415],"tags":[33896,33895,34248,29798,29313,29783,28445],"class_list":["post-357019","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bonnes-nouvelles","tag-cancer-fr","tag-cellules","tag-innovation-fr","tag-medecine","tag-recherche","tag-sante","tag-technologie"],"better_featured_image":{"id":298492,"alt_text":"A researcher at the Technion Israel Institute of Technology in Haifa (Hadas Parush\/Flash90)","caption":"A researcher at the Technion Israel Institute of Technology in Haifa (Hadas Parush\/Flash90)","description":"Pesquisador no Instituto Technion na cidade de Haifa (Hadas 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