{"id":349653,"date":"2020-05-18T09:46:22","date_gmt":"2020-05-18T06:46:22","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=349653"},"modified":"2021-04-26T14:32:24","modified_gmt":"2021-04-26T11:32:24","slug":"coronavirus-pourquoi-certains-sont-plus-severement-touches-que-dautres-une-etude-israelienne-a-la-reponse","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/coronavirus-pourquoi-certains-sont-plus-severement-touches-que-dautres-une-etude-israelienne-a-la-reponse\/","title":{"rendered":"Coronavirus: Pourquoi certains sont plus s\u00e9v\u00e8rement touch\u00e9s que d’autres? Une \u00e9tude isra\u00e9lienne a la r\u00e9ponse"},"content":{"rendered":"

Une \u00e9tude men\u00e9e par Isra\u00ebl r\u00e9v\u00e8le que des cellules immunitaires nocives envahissent les poumons des patients gravement touch\u00e9s par Covid-19, \u00e9vin\u00e7ant ainsi les cellules immunitaires utiles.<\/strong><\/em><\/p>\n

Par Abigail Klein Leichman, ISRAEL21c<\/em><\/p>\n

La fragilit\u00e9 du syst\u00e8me immunitaire pourrait \u00eatre responsable du fait que certains patients atteints de Covid-19 se portent moins bien que d’autres, sugg\u00e8re une nouvelle \u00e9tude internationale dirig\u00e9e par des chercheurs en immunologie \u00e0 l’Institut Weizmann des Sciences d’Isra\u00ebl.<\/p>\n

Publi\u00e9e dans la revue Cell le 7 mai, \u00abLes cartes des infections virales de l’h\u00f4te r\u00e9v\u00e8lent des signatures de patients COVID-19 s\u00e9v\u00e8res<\/em>\u00bb, Viral-Track, une m\u00e9thode informatique qu’ils ont valid\u00e9e pour d\u00e9tecter syst\u00e9matiquement les virus de plusieurs mod\u00e8les d’infection, a \u00e9t\u00e9 pr\u00e9sent\u00e9e par les chercheurs du laboratoire du Professeur Ido Amit.<\/p>\n

Ils ont appliqu\u00e9 Viral-Track \u00e0 des \u00e9chantillons de cellules pulmonaires de trois patients Covid-19 b\u00e9nins et six patients graves pour \u00e9tudier comment le virus SARS-CoV-2 modifiait le paysage cellulaire pulmonaire.<\/p>\n

Ils ont constat\u00e9 \u00ab\u00a0un impact dramatique du virus sur le syst\u00e8me immunitaire des patients s\u00e9v\u00e8res par rapport aux cas b\u00e9nins\u00a0\u00bb<\/em>, rapportent les auteurs, y compris des chercheurs du laboratoire Zheng du Shenzhen Third People\u2019s Hospital et de l\u2019Institut Pasteur de Paris.<\/p>\n

Dans les poumons des patients gravement touch\u00e9s par Covid-19, les cellules immunitaires des macrophages alv\u00e9olaires utiles semblent \u00eatre remplac\u00e9es par une temp\u00eate de cellules immunitaires my\u00e9lo\u00efdes nocives qui intensifient l’impact du virus.<\/p>\n

Le co-auteur Amir Giladi a d\u00e9clar\u00e9 que ce dysfonctionnement du syst\u00e8me immunitaire \u00abrepr\u00e9sentait le v\u00e9ritable myst\u00e8re du coronavirus\u00bb.<\/em><\/p>\n

\u00ab\u00a0L’application de Viral-Track \u00e0 de plus grandes cohortes cliniques pourrait fournir une compr\u00e9hension m\u00e9canique critique des interactions SARS-CoV-2 avec son h\u00f4te humain et concevoir de nouvelles strat\u00e9gies de traitement pour les patients s\u00e9v\u00e8res\u00a0\u00bb<\/em>, a tweet\u00e9 le laboratoire d’Amit.<\/p>\n

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Une \u00e9tude men\u00e9e par Isra\u00ebl r\u00e9v\u00e8le que des cellules immunitaires nocives envahissent les poumons des patients gravement touch\u00e9s par Covid-19, \u00e9vin\u00e7ant ainsi les cellules immunitaires utiles. Par Abigail Klein Leichman, ISRAEL21c La fragilit\u00e9 du syst\u00e8me immunitaire pourrait \u00eatre responsable du fait que certains patients atteints de Covid-19 se portent moins bien que d’autres, sugg\u00e8re une… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":345938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418,41155],"tags":[30152,37426,37424,28978,29313,29783],"class_list":["post-349653","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","category-combat-disrael-contre-le-covid-19","tag-chercheurs","tag-coronavirus-fr","tag-epidemie","tag-etude","tag-recherche","tag-sante"],"better_featured_image":{"id":345938,"alt_text":"","caption":"Shutterstock","description":"","media_type":"image","media_details":{"width":2560,"height":2194,"file":"2020\/04\/shutterstock_1694189149-scaled.jpg","sizes":{"medium":{"file":"shutterstock_1694189149-300x257.jpg","width":300,"height":257,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-300x257.jpg"},"large":{"file":"shutterstock_1694189149-1024x878.jpg","width":1024,"height":878,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-1024x878.jpg"},"thumbnail":{"file":"shutterstock_1694189149-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-150x150.jpg"},"medium_large":{"file":"shutterstock_1694189149-768x658.jpg","width":768,"height":658,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-768x658.jpg"},"1536x1536":{"file":"shutterstock_1694189149-1536x1317.jpg","width":1536,"height":1317,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-1536x1317.jpg"},"2048x2048":{"file":"shutterstock_1694189149-2048x1755.jpg","width":2048,"height":1755,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-2048x1755.jpg"},"uwi-full-width":{"file":"shutterstock_1694189149-607x520.jpg","width":607,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-607x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1694189149-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1694189149-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1694189149-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1694189149-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1694189149-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1694189149-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-250x170.jpg"},"uwi-email":{"file":"shutterstock_1694189149-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1694189149-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_1694189149-1136x640.jpg","width":1136,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-1136x640.jpg"},"uwi-ipad":{"file":"shutterstock_1694189149-1024x768.jpg","width":1024,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/04\/shutterstock_1694189149-1024x768.jpg"},"uwi-ipad-x2":{"file":"shutterstock_169418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