{"id":334112,"date":"2020-02-18T10:06:22","date_gmt":"2020-02-18T07:06:22","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=334112"},"modified":"2020-02-18T15:27:59","modified_gmt":"2020-02-18T12:27:59","slug":"medecine-avancee-israelienne-spectaculaire-en-matiere-de-maladies-cardiaques","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/medecine-avancee-israelienne-spectaculaire-en-matiere-de-maladies-cardiaques\/","title":{"rendered":"M\u00e9decine: avanc\u00e9e isra\u00e9lienne sp\u00e9ctaculaire en mati\u00e8re de maladies cardiaques"},"content":{"rendered":"

La technologie ouvre la voie \u00e0 des traitements et des implants r\u00e9volutionnaires pour les zones endommag\u00e9es du c\u0153ur.<\/strong><\/em><\/p>\n

Par l’\u00e9quipe d’Unis avec Isra\u00ebl<\/em><\/p>\n

Les chercheurs ont r\u00e9ussi \u00e0 produire des tissus cardiaques con\u00e7us en 3D \u00e0 partir de cellules cardiaques sp\u00e9cifiques \u00e0 la zone, d\u00e9riv\u00e9es de cellules souches humaines. Ce d\u00e9veloppement m\u00e9dical ouvre la porte \u00e0 la cr\u00e9ation de m\u00e9dicaments personnalis\u00e9s pour les patients cardiaques et aux avanc\u00e9es dans le d\u00e9veloppement de nouveaux traitements cardiaques. Cette perc\u00e9e a \u00e9t\u00e9 publi\u00e9e r\u00e9cemment dans Nature Communications.<\/p>\n

Ce mod\u00e8le de recherche simule le rythme cardiaque irr\u00e9gulier le plus courant (arythmie), appel\u00e9 fibrillation auriculaire. Il ouvre la porte pour tester le succ\u00e8s de divers m\u00e9dicaments sur des patients individuels afin de pr\u00e9venir ou d’arr\u00eater l’arythmie.<\/p>\n

Parce qu’ils ont pu s\u00e9parer les mod\u00e8les de tissus auriculaires et ventriculaires, les chercheurs peuvent d\u00e9couvrir quels m\u00e9dicaments am\u00e9liorent la fonction des cellules auriculaires sans endommager la fonction des cellules ventriculaires.<\/p>\n

\u00ab\u00a0La s\u00e9paration entre ces deux types de tissus est importante car les m\u00e9dicaments qui peuvent am\u00e9liorer la fonction des cellules auriculaires et ainsi pr\u00e9venir les arythmies sont susceptibles de nuire \u00e0 la fonction des cellules ventriculaires et m\u00eame d’induire des arythmies ventriculaires<\/em>\u00ab\u00a0, a d\u00e9clar\u00e9 le professeur Lior Gepstein du Technion Institute and Rambam Health Care Medical Center in Israel.<\/p>\n

\u00abPar exemple, pour la fibrillation auriculaire – le type de rythme cardiaque irr\u00e9gulier le plus courant qui est \u00e9galement responsable de plus d’un quart de tous les accidents vasculaires c\u00e9r\u00e9braux – nous voulons influencer l’activit\u00e9 \u00e9lectrique des cellules auriculaires \u00e0 l’aide de m\u00e9dicaments, sans affecter la fonction du tissu ventriculaire . Maintenant que nous pouvons fabriquer individuellement les cellules de l’oreillette et du ventricule, nous pouvons tester chaque m\u00e9dicament pour chaque type de cellule s\u00e9par\u00e9ment<\/em> \u00bb, a ajout\u00e9 Gepstein.<\/p>\n

Gepstein esp\u00e8re \u00abque nous pourrons utiliser des m\u00e9thodes similaires pour produire \u00e9galement du tissu cardiaque pour les transplantations chez les patients cardiaques. Ces tissus seront bien re\u00e7us car ils sont bas\u00e9s sur les caract\u00e9ristiques g\u00e9n\u00e9tiques du patient lui-m\u00eame.<\/em> \u00a0\u00bb<\/p>\n

Comme les greffes d’organes provenant de sources ext\u00e9rieures sont souvent rejet\u00e9es, ce mod\u00e8le, produit par les cellules et les tissus du patient, contournerait ce d\u00e9fi. Ce processus avanc\u00e9 fonctionne en collectant la peau ou les cellules sanguines adultes du patient, en les reprogrammant dans une sorte de \u00abtunnel temporel cellulaire<\/em>\u00bb qui les ram\u00e8ne \u00e0 l’\u00e9tat des premi\u00e8res cellules du corps, ressemblant \u00e0 des cellules souches embryonnaires.<\/p>\n

Le mod\u00e8le de Gepstein est capable de \u00abtester diff\u00e9rents traitements en laboratoire et de choisir \u00e0 l’avance le traitement optimal pour le patient sp\u00e9cifique\u00bb<\/em>.<\/p>\n

\u00ab\u00a0Ce travail a \u00e9galement d\u00e9montr\u00e9 la possibilit\u00e9 d’utiliser l’\u00e9dition g\u00e9n\u00e9tique (CRISPR) pour corriger la mutation conduisant \u00e0 l’arythmie dans cette maladie, fournissant des preuves de concept pour le potentiel de cette approche pour le traitement des troubles g\u00e9n\u00e9tiques \u00e0 l’avenir\u00a0\u00bb<\/em>, a d\u00e9clar\u00e9 Gepstein.<\/p>\n

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La technologie ouvre la voie \u00e0 des traitements et des implants r\u00e9volutionnaires pour les zones endommag\u00e9es du c\u0153ur. Par l’\u00e9quipe d’Unis avec Isra\u00ebl Les chercheurs ont r\u00e9ussi \u00e0 produire des tissus cardiaques con\u00e7us en 3D \u00e0 partir de cellules cardiaques sp\u00e9cifiques \u00e0 la zone, d\u00e9riv\u00e9es de cellules souches humaines. Ce d\u00e9veloppement m\u00e9dical ouvre la porte… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":251926,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[37631,30739,29798,29783,28846],"class_list":["post-334112","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-cardiaques","tag-coeur","tag-medecine","tag-sante","tag-traitement"],"better_featured_image":{"id":251926,"alt_text":"","caption":"Good news Israel. Irregular heartbeat. 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