{"id":317060,"date":"2019-10-09T22:50:56","date_gmt":"2019-10-09T19:50:56","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=317060"},"modified":"2019-10-10T10:39:50","modified_gmt":"2019-10-10T07:39:50","slug":"decouverte-dun-vaccin-israelo-allemand-contre-le-virus-ebola","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/decouverte-dun-vaccin-israelo-allemand-contre-le-virus-ebola\/","title":{"rendered":"D\u00e9couverte d&rsquo;un vaccin isra\u00e9lo-allemand contre le virus Ebola"},"content":{"rendered":"<p class=\"lead\"><em><strong>Des scientifiques en Isra\u00ebl et en Allemagne ont montr\u00e9 qu&rsquo;un vaccin exp\u00e9rimental offrait une protection \u00e0 long terme contre cette maladie mortelle.<\/strong><\/em><\/p>\n<p><em>Par ISRAEL21c<\/em><\/p>\n<p>Pour lutter contre les \u00e9pid\u00e9mies d&rsquo;Ebola mortelles et r\u00e9currentes dans certaines r\u00e9gions d&rsquo;Afrique, les personnels de sant\u00e9 ont administr\u00e9 des vaccins \u00e0 plus de 100 000 personnes.<\/p>\n<p>Cependant, les vaccins anti-Ebola sont \u00e0 peine sortis du stade exp\u00e9rimental. Personne ne sait s\u2019ils peuvent assurer une protection \u00e0 long terme \u00e0 une large population. Et personne n&rsquo;a compris l&rsquo;effet de ces vaccins sur le syst\u00e8me immunitaire.<\/p>\n<p>Un laboratoire de recherche de l\u2019Institut Weizmann des sciences d\u2019Isra\u00ebl s\u2019est r\u00e9cemment associ\u00e9 \u00e0 une \u00e9quipe de chercheurs \u00e0 Cologne, en Allemagne, pour d\u00e9couvrir les d\u00e9tails de la r\u00e9ponse mol\u00e9culaire qui se produit dans le syst\u00e8me immunitaire apr\u00e8s la vaccination contre Ebola.<\/p>\n<p>Leurs d\u00e9couvertes pourraient aider les organisations de sant\u00e9 \u00e0 \u00e9laborer de meilleures strat\u00e9gies pour contenir et pr\u00e9venir la maladie, qui n\u2019est actuellement pas gu\u00e9rie, et tue environ 50% des personnes infect\u00e9es.<\/p>\n<p><em>\u00abCes vaccins &#8211; fabriqu\u00e9s \u00e0 l&rsquo;aide de m\u00e9thodes recombinantes liant une prot\u00e9ine Ebola \u00e0 un virus inoffensif &#8211; sont difficiles \u00e0 produire et ne sont donc pas assez nombreux pour vacciner une population enti\u00e8re\u00bb,<\/em> a d\u00e9clar\u00e9 le biologiste des structures, Ron Diskin, de l&rsquo;Institut Weizmann.<\/p>\n<p>De plus, a-t-il ajout\u00e9, les vaccins atteignent rarement les villages isol\u00e9s o\u00f9 ils sont le plus n\u00e9cessaires. Ils ont tendance \u00e0 \u00eatre donn\u00e9s uniquement aux personnes les plus proches des personnes d\u00e9j\u00e0 malades.<\/p>\n<p>\u00ab<em>Comprendre exactement comment la r\u00e9ponse immunitaire est produite apr\u00e8s la vaccination ne contribuera pas seulement \u00e0 affiner le vaccin. Cela peut nous aider \u00e0 comprendre si cela va agir contre diff\u00e9rentes souches du virus ou si la dose administr\u00e9e aujourd&rsquo;hui est la meilleure<\/em> \u00bb, a d\u00e9clar\u00e9 Diskin.<\/p>\n<p>L&rsquo;\u00e9tude a d\u00e9but\u00e9 dans le laboratoire de l&rsquo;immunologiste Dr. Florian Klein de l&rsquo;Universit\u00e9 de Cologne. Klein et son groupe ont recherch\u00e9 des signes de r\u00e9ponse immunitaire dans des \u00e9chantillons de sang de six personnes qui avaient re\u00e7u le vaccin un an ou plus auparavant.<\/p>\n<p>Le groupe a distingu\u00e9 les cellules B &#8211; celles qui produisent les anticorps qui constituent notre <em>\u00abm\u00e9moire immunitaire<\/em>\u00bb &#8211; et proc\u00e9d\u00e9 \u00e0 un s\u00e9quen\u00e7age en profondeur, en tra\u00e7ant les lign\u00e9es de ces cellules et en isolant des anticorps individuels se liant \u00e0 des prot\u00e9ines virales.<\/p>\n<p>Les cellules de chacune des six personnes ont produit un grand nombre d&rsquo;anticorps. Diskin et son \u00e9quipe se sont concentr\u00e9s sur deux prometteurs, dont ils pensaient qu&rsquo;ils \u00e9taient fortement impliqu\u00e9s dans la r\u00e9ponse immunitaire \u00e0 long terme.<\/p>\n<p>Pour comprendre exactement comment et o\u00f9 les anticorps se lient au virus inoffensif contenu dans le vaccin et comment cette liaison neutralise le virus de mani\u00e8re aussi efficace, l&rsquo;\u00e9quipe a utilis\u00e9 un nouveau microscope \u00e9lectronique \u00e0 haute puissance pour r\u00e9v\u00e9ler la structure tridimensionnelle, pratiquement jusqu&rsquo;au dernier atome, d&rsquo;un anticorps li\u00e9 \u00e0 sa cible.<\/p>\n<p>Cette analyse a permis au groupe de recherche de montrer pourquoi les deux anticorps caract\u00e9ris\u00e9s par Diskin et son groupe \u00e9taient particuli\u00e8rement efficaces pour arr\u00eater Ebola.<\/p>\n<p>Ils ont pu distinguer la composition exacte de ces anticorps et cartographier les points pr\u00e9cis auxquels ils se sont fix\u00e9s \u00e0 la prot\u00e9ine virale.<\/p>\n<p><em>\u00abEn fait, dit Diskin, les anticorps que nous avons \u00e9tudi\u00e9s sont beaucoup plus efficaces pour se lier que ceux actuellement test\u00e9s pour traiter Ebola.\u00bb<\/em><\/p>\n<p>La comparaison de la carte des sites de liaison avec ceux \u00e9tudi\u00e9s chez les survivants du virus Ebola, connus pour leur effet protecteur, a montr\u00e9 une tendance presque identique. D&rsquo;autres recherches ont test\u00e9 les anticorps contre la prot\u00e9ine Ebola &#8211; m\u00eame contre le virus vivant &#8211; et ont finalement expliqu\u00e9 le m\u00e9canisme de protection.<\/p>\n<p>On ne sait pas encore si le vaccin qu&rsquo;ils ont test\u00e9 peut produire une r\u00e9ponse immunitaire contre d&rsquo;autres esp\u00e8ces du virus Ebola. Mais l&rsquo;\u00e9tude sugg\u00e8re que les anticorps ont bien fonctionn\u00e9 contre plusieurs isolats d&rsquo;une m\u00eame esp\u00e8ce et Diskin esp\u00e8re que des recherches ult\u00e9rieures montreront un seul vaccin capable de lutter contre la maladie sur tout le continent.<\/p>\n<p>Les recherches de Diskin sont soutenues par le Moross Integrated Cancer Center; l&rsquo;Institut de chimie m\u00e9dicinale Dr. Barry Sherman; le Centre de recherche en sciences de la vie Jeanne et Joseph Nissim; et le domaine d&rsquo;Emile Mimran.<\/p>\n<shortcode  style=\"display:block\" ><div class=\"cta-boxed\"><h2>Do You Love Israel? Make a Donation - Show Your Support!<\/h2><div class=\"wp-caption alignright\" style=\"width: 260px\"><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\"><img decoding=\"async\" class=\"size-medium\" src=\"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2022\/06\/shutterstock_1528562331.jpeg\" alt=\"\" width=\"260\"><\/a><p class=\"wp-caption-text\"><\/p><\/div><p><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p><p> Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p><p> Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. <a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Help us fight back!<\/strong><\/a>  <\/p> <p style=\"text-align: left;\"><strong><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\">STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode><non-auwi><ad-shortcode><div style=\"margin-top:20px;display:block\"><a href=\"https:\/\/donate.unitedwithisrael.org\/donate\/G1S\/?a=uwi_es_art_bnr_atk\"><img decoding=\"async\" class=\"no-border\" style=\"padding:0;\" src=\"https:\/\/unitedwithisrael.org\/wp-content\/uploads\/2015\/11\/ad_890x100_es.jpg\" alt=\"Donate to Israel\" \/><\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"<p>Des scientifiques en Isra\u00ebl et en Allemagne ont montr\u00e9 qu&rsquo;un vaccin exp\u00e9rimental offrait une protection \u00e0 long terme contre cette maladie mortelle. Par ISRAEL21c Pour lutter contre les \u00e9pid\u00e9mies d&rsquo;Ebola mortelles et r\u00e9currentes dans certaines r\u00e9gions d&rsquo;Afrique, les personnels de sant\u00e9 ont administr\u00e9 des vaccins \u00e0 plus de 100 000 personnes. Cependant, les vaccins anti-Ebola&#8230;  <a href=\"https:\/\/kinsta.unitedwithisrael.org\/fr\/uwi_shortcodes\/donate\/\" class=\"more-link\" title=\"Read donate\">Read more &raquo;<\/a><\/p>\n","protected":false},"author":4242,"featured_media":250262,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28414],"tags":[36013,36012,29306,29798,29783,28846,29952],"class_list":["post-317060","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-influence-israelienne","tag-ebola-fr","tag-immunitaire","tag-maladie","tag-medecine","tag-sante","tag-traitement","tag-vaccin"],"better_featured_image":{"id":250262,"alt_text":"","caption":"(Shutterstock)","description":"Vaccine. (Shutterstock)","media_type":"image","media_details":{"width":1000,"height":666,"file":"2015\/01\/shutterstock_228612739.jpg","sizes":{"thumbnail":{"file":"shutterstock_228612739-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings - Previously Optimized","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/01\/shutterstock_228612739-150x150.jpg"},"medium":{"file":"shutterstock_228612739-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings - Previously Optimized","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/01\/shutterstock_228612739-300x200.jpg"},"uwi-full-width":{"file":"shutterstock_228612739-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings - Previously Optimized","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/01\/shutterstock_228612739-780x520.jpg"},"uwi-square-medium":{"file":"shutterstock_228612739-200x200.jpg","width":200,"height":200,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings - 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