{"id":293910,"date":"2019-05-01T10:59:11","date_gmt":"2019-05-01T07:59:11","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=293910"},"modified":"2019-05-01T12:19:57","modified_gmt":"2019-05-01T09:19:57","slug":"des-israeliens-decouvrent-un-traitement-contre-lepilepsie-severe","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/des-israeliens-decouvrent-un-traitement-contre-lepilepsie-severe\/","title":{"rendered":"Des isra\u00e9liens d\u00e9couvrent un traitement contre l’\u00e9pilepsie s\u00e9v\u00e8re !"},"content":{"rendered":"

Des chercheurs de l’Universit\u00e9 de Tel-Aviv ont d\u00e9couvert qu’un traitement courant de la scl\u00e9rose en plaques pouvait avoir d’importantes applications pour l’\u00e9pilepsie, notamment le syndrome de Dravet, qui touche les enfants et entra\u00eene un taux de mortalit\u00e9 de 20%. <\/strong><\/em><\/p>\n

Par: The Algemeiner<\/em><\/p>\n

Des scientifiques du laboratoire de la professeure Inna Slutsky \u00e0 l’Universit\u00e9 de Tel Aviv ont publi\u00e9 leur rapport sur les effets d’un m\u00e9dicament contre la scl\u00e9rose en plaques appliqu\u00e9 \u00e0 l’\u00e9pilepsie lundi dans la revue Neuron.
\nSlutsky a d\u00e9clar\u00e9 que le m\u00e9dicament en question, le t\u00e9riflunomide, affectait la stabilit\u00e9 de l’activit\u00e9 neuronale. Il peut aider \u00e0 pr\u00e9server la stabilit\u00e9 des processus c\u00e9r\u00e9braux, emp\u00eachant ainsi la d\u00e9stabilisation qui conduit \u00e0 des crises d’\u00e9pilepsie. \u00ab\u00a0Nous avons trouv\u00e9 un m\u00e9canisme hom\u00e9ostatique qui agit comme une sorte de thermostat des circuits neuronaux, qui assure le retour \u00e0 un ensemble<\/em> \u00a0\u00bb<\/p>\n

Faisant r\u00e9f\u00e9rence au g\u00e8ne dihydroorotate d\u00e9shydrog\u00e9nase (DHODH), source d’\u00e9nergie dans les cellules, Slutsky a d\u00e9clar\u00e9: \u00ab\u00a0nos donn\u00e9es sugg\u00e8rent que l’inhibition de la DHODH par le m\u00e9dicament Teriflunomide est approuv\u00e9e<\/em>\u00a0\u00bb pour le traitement de la scl\u00e9rose en plaques en raison de ses actions immunosuppressives dans le sang, entrainant une inhibition stable de l’activit\u00e9 neuronale, sans alt\u00e9rer les m\u00e9canismes de compensation des perturbations d\u00e9pendantes de l’activit\u00e9.<\/p>\n

\u00ab\u00a0Des tests effectu\u00e9s sur des souris ont montr\u00e9 que l’injection de t\u00e9riflunomide induit un retour \u00e0 une activit\u00e9 c\u00e9r\u00e9brale normale et diminue l’intensit\u00e9 des crises d’\u00e9pilepsie.<\/em> \u00a0\u00bb
\nLes m\u00e9dicaments fond\u00e9s sur ce nouveau principe peuvent donner de l’espoir \u00e0 30 \u00e0 40% des patients atteints d’\u00e9pilepsie, qui ne r\u00e9pondent pas aux traitements existants, y compris les enfants atteints du syndrome de Dravet, dont environ 20% meurent des suites de la maladie , a d\u00e9clar\u00e9 Slutsky. Elle pense que le m\u00e9dicament pourrait \u00e9galement \u00eatre utilis\u00e9 dans le traitement d’autres troubles c\u00e9r\u00e9braux.\u00a0\u00bb Nous examinons actuellement s’il existe une d\u00e9faillance de la r\u00e9gulation du point de consigne d’activit\u00e9 dans la maladie d’Alzheimer<\/em> \u00bb, a-t-elle d\u00e9clar\u00e9. \u00abSi tel est le cas, cela pourrait constituer un nouveau moyen conceptuel de traiter les troubles de la m\u00e9moire\u00a0\u00bb.<\/em><\/p>\n

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Des chercheurs de l’Universit\u00e9 de Tel-Aviv ont d\u00e9couvert qu’un traitement courant de la scl\u00e9rose en plaques pouvait avoir d’importantes applications pour l’\u00e9pilepsie, notamment le syndrome de Dravet, qui touche les enfants et entra\u00eene un taux de mortalit\u00e9 de 20%. Par: The Algemeiner Des scientifiques du laboratoire de la professeure Inna Slutsky \u00e0 l’Universit\u00e9 de Tel… Read more »<\/a><\/p>\n","protected":false},"author":4242,"featured_media":246183,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28418],"tags":[34044,34043,29798,31464,29313,31910,28846],"class_list":["post-293910","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites-israeliennes","tag-decouverte","tag-epilepsie","tag-medecine","tag-medicament","tag-recherche","tag-sciences","tag-traitement"],"better_featured_image":{"id":246183,"alt_text":"","caption":"Israeli scientists in action.(Photo: hadassah-med.com)","description":"Israeli scientists at Hadassah medical school","media_type":"image","media_details":{"width":299,"height":209,"file":"2014\/09\/israeli-sceintests.jpg","sizes":{"thumbnail":{"file":"israeli-sceintests-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings - 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