{"id":219387,"date":"2018-04-19T18:00:13","date_gmt":"2018-04-19T15:00:13","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=219387\/"},"modified":"2018-04-20T14:54:39","modified_gmt":"2018-04-20T11:54:39","slug":"un-scientifique-israelien-fait-une-avancee-majeure-en-matiere-du-traitement-dalzheimer","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/fr\/un-scientifique-israelien-fait-une-avancee-majeure-en-matiere-du-traitement-dalzheimer\/","title":{"rendered":"Un scientifique isra\u00e9lien fait une avanc\u00e9e majeure en mati\u00e8re du traitement d&rsquo;Alzheimer!"},"content":{"rendered":"<p class=\"lead\"><strong><em>Un scientifique isra\u00e9lien travaillant sur un vaccin contre la maladie d&rsquo;Alzheimer a fait des perc\u00e9es consid\u00e9rables dans le d\u00e9veloppement de traitements de cette maladie r\u00e9pandue<\/em><\/strong><\/p>\n<p><em>Par: Abigail Klein Leichman, Israel21c<\/em><\/p>\n<p>La maladie d&rsquo;Alzheimer, qui touche 47 millions de personnes \u00e0 travers le monde, reste \u00e0 ce jour une maladie du cerveau irr\u00e9versible et fatale. En adoptant une approche proactive, un chercheur isra\u00e9lien sp\u00e9cialiste du cerveau est en train de d\u00e9velopper un vaccin contre cette maladie d\u00e9vastatrice.<\/p>\n<p>La plupart des vaccins agissent en renfor\u00e7ant une r\u00e9ponse immunitaire contre un pathog\u00e8ne affaibli afin de renforcer la capacit\u00e9 du syst\u00e8me immunitaire \u00e0 combattre le vrai pathog\u00e8ne. Le vaccin du Professeur Eitan Okun pr\u00e9pare le corps \u00e0 attaquer les accumulations de b\u00e9ta prot\u00e9ine dans le cerveau, l&rsquo;un des signes caract\u00e9ristiques de la maladie d&rsquo;Alzheimer.<\/p>\n<p>Les exp\u00e9riences sur micelles men\u00e9es dans le laboratoire Paul E. Feder d&rsquo;Okuns \u00e0 l&rsquo;Universit\u00e9 de Bar Ilan \u00e0 Ramat Gan se seraient jusqu&rsquo;ici r\u00e9v\u00e9l\u00e9es tr\u00e8s prometteuses.<\/p>\n<p>Il s&rsquo;appr\u00eate d\u00e9sormais \u00e0 envisager des essais humains sur des personnes pr\u00e9sentant un risque de d\u00e9velopper la maladie \u00e0 la cinquantaine, ou plus jeunes! celles g\u00e9n\u00e9tiquement pr\u00e9dispos\u00e9es \u00e0 la maladie d&rsquo;Alzheimer et les personnes pr\u00e9sentant le symptome de Down.<\/p>\n<p>\u00ab\u00a0<em>Ces essais critiques d\u00e9termineront si le vaccin fonctionne effectivement sur des humains<\/em>\u00ab\u00a0, a d\u00e9clar\u00e9 Okun, qui effectue \u00e9galement des recherches sur la raison pour laquelle les personnes pr\u00e9sentant le syndrome de Down sont plus aptes \u00e0 d\u00e9velopper celui d&rsquo;Alzheimer. Les souris utilis\u00e9es pour ses exp\u00e9riences \u00e9taient con\u00e7ues pour imiter le syndrome de Down.<\/p>\n<p>\u00ab\u00a0<em>En fonction du taux de r\u00e9ussite et des effets secondaires des tests sur humains, nous serons en mesure de savoir combien de temps suppl\u00e9mentaire sera n\u00e9cessaire pour rendre le vaccin disponible \u00e0 \u00e9chelle mondiale. Je suis convaincu que le vaccin est le moyen d&rsquo;agir sur les maladies neurod\u00e9g\u00e9n\u00e9ratives<\/em>\u00ab\u00a0, a d\u00e9clair\u00e9 Okun.<\/p>\n<p>Au-del\u00e0 de son potentiel vaccin r\u00e9volutionnaire, Okun cherche des nouveaux moyens de diagnostiquer la maladie d&rsquo;Alzheimer plus t\u00f4t et plus pr\u00e9cis\u00e9ment en utilisant des technologies IRM avanc\u00e9es afin de d\u00e9tecter les signes initiaux d&rsquo;accumulation de prot\u00e9ines amylo\u00efdes dans le cerveau.<\/p>\n<p>\u00ab\u00a0<em>Mes chercheurs et moi-m\u00eame avons cherch\u00e9 \u00e0 construire une prot\u00e9ine qui pourrait infiltrer la circulation sanguine, le faire par la barri\u00e8re h\u00e9mato-enc\u00e9phalique, se lier aux amylo\u00efdes et devenir ainsi visibles par IRM\u00a0\u00bb<\/em>, a t-il d\u00e9clar\u00e9.<\/p>\n<p><em>\u00ab\u00a0Je recherche toujours de nouveaux angles pour attaquer cette maladie. Je n&rsquo;ai jamais \u00e9t\u00e9 plus optimistes sur le fait que la pr\u00e9vention de la maladie serait r\u00e9alis\u00e9e<\/em>\u00ab\u00a0.<\/p>\n<h2>Cibles pour une intervention rapide<\/h2>\n<p>Okun, 39 ans, a obtenu son master et son doctorat en immunologie \u00e0 Bar-Ilan et a r\u00e9alis\u00e9 un partenariat post-doctoral \u00e0 l&rsquo;Institut National de la Sant\u00e9 aux Etats-Unis.<\/p>\n<p>Il est charg\u00e9 d&rsquo;enseignement \u00e0 la fois au Centre de Recherche Multidisciplinaire sur le Cerveau Leslie Susan Gonda (Goldschmeid) et \u00e0 la facult\u00e9 de Sciences de la Vie Mina et Everard Goodman \u00e0 Bar Ilan.<\/p>\n<p>A c\u00f4t\u00e9 de ses vaccins, il pr\u00e9conise une combinaison d&rsquo;exercices physiques et de stimulations environnementales qui peuvent aider le cerveau \u00e0 \u00e9viter la maladie d&rsquo;Alzheimer en augmentant et renfor\u00e7ant les liens de l&rsquo;\u00e9pine dendritique, qui mod\u00e8re notre capacit\u00e9 \u00e0 g\u00e9n\u00e9rer des souvenirs.<\/p>\n<p>\u00ab\u00a0<em>Dans notre laboratoire, nous utilisons des techniques multidisciplinaires pour atteindre deux objectifs: identifier les m\u00e9canismes neurologiques associ\u00e9s au d\u00e9ficit cognitif, et, dans le m\u00eame temps, chercher des signaux qui permettraient aux physiciens d&rsquo;identifier les patients \u00e0 risque, afin qu&rsquo;ils puissent recevoir des traitements pr\u00e9ventifs pour d\u00e9mence avant qu&rsquo;il ne soit trop tard<\/em>\u00ab\u00a0, a d\u00e9clar\u00e9 Okun.<\/p>\n<p>Il \u00e9tudie \u00e9galement les moyens de mieux pr\u00e9venir et diagnostiquer d&rsquo;autres conditions neurologiques, telles que la maladie de Parkinson.<\/p>\n<p>\u00ab\u00a0<em>Actuellement, il n&rsquo;y a pas de traitement pour les maladies neurod\u00e9g\u00e9n\u00e9ratives telles qu&rsquo;Alzheimer et Parkinson, et la science m\u00e9dicale peut seulement identifier quelques conditions de comportement (\u00e0 travers les sympt\u00f4mes qui indiquent que le tissu c\u00e9r\u00e9bral a d\u00e9j\u00e0 \u00e9t\u00e9 d\u00e9truit&rsquo;), a<\/em> t-il expliqu\u00e9.<\/p>\n<p>\u201c<em>Notre challenge est de trouver les indices dans la biologie mol\u00e9culaire et la biochimie du cerveau qui indiqueraient qu&rsquo;il y a un probl\u00e8me, et qui nous donneraient \u00e9galement des cibles pour une intervention m\u00e9dicamenteuse pr\u00e9coce<\/em>\u00ab\u00a0.<\/p>\n<p>Bien qu&rsquo;il ait \u00e9tudi\u00e9 le cerveau pendant plusieurs ann\u00e9es, Okun a acquis une perspective personnelle quant \u00e0 l&rsquo;importance de la recherche sur la neurod\u00e9g\u00e9n\u00e9ration lorsque l&rsquo;on a diagnostiqu\u00e9 une d\u00e9mence \u00e0 son p\u00e8re alors qu&rsquo;il avait la soixantaine.<\/p>\n<p>\u00ab\u00a0<em>Au moment o\u00f9 les changements dans ses fonctions moteur et cognitives sont devenus apparents, le tissu c\u00e9r\u00e9bral \u00e9tait d\u00e9j\u00e0 perdu. J&rsquo;ai l&rsquo;espoir que, en acqu\u00e9rant une compr\u00e9hension plus compl\u00e8te de ce qui se produit dans nos cerveaux lorsque nous vieillissons, nous seront capables d&rsquo;aider davantage de personnes \u00e0 vivre une vie plus pleine et plus saine cognitivement\u00a0\u00bb<\/em>.<\/p>\n<shortcode  style=\"display:block\" ><div class=\"cta-boxed\"><h2>Do You Love Israel? Make a Donation - Show Your Support!<\/h2><div class=\"wp-caption alignright\" style=\"width: 260px\"><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\"><img decoding=\"async\" class=\"size-medium\" src=\"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2022\/06\/shutterstock_1528562331.jpeg\" alt=\"\" width=\"260\"><\/a><p class=\"wp-caption-text\"><\/p><\/div><p><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p><p> Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p><p> Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. <a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Help us fight back!<\/strong><\/a>  <\/p> <p style=\"text-align: left;\"><strong><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\">STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode><non-auwi><ad-shortcode><div style=\"margin-top:20px;display:block\"><a href=\"https:\/\/donate.unitedwithisrael.org\/donate\/G1S\/?a=uwi_es_art_bnr_atk\"><img decoding=\"async\" class=\"no-border\" style=\"padding:0;\" src=\"https:\/\/unitedwithisrael.org\/wp-content\/uploads\/2015\/11\/ad_890x100_es.jpg\" alt=\"Donate to Israel\" \/><\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"<p>Un scientifique isra\u00e9lien travaillant sur un vaccin contre la maladie d&rsquo;Alzheimer a fait des perc\u00e9es consid\u00e9rables dans le d\u00e9veloppement de traitements de cette maladie r\u00e9pandue Par: Abigail Klein Leichman, Israel21c La maladie d&rsquo;Alzheimer, qui touche 47 millions de personnes \u00e0 travers le monde, reste \u00e0 ce jour une maladie du cerveau irr\u00e9versible et fatale. En&#8230;  <a href=\"https:\/\/kinsta.unitedwithisrael.org\/fr\/uwi_shortcodes\/donate\/\" class=\"more-link\" title=\"Read donate\">Read more &raquo;<\/a><\/p>\n","protected":false},"author":4242,"featured_media":162271,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[28415],"tags":[25578,29954,29951,29950,29953,29306,29955,29313,29952],"class_list":["post-219387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bonnes-nouvelles","tag-alzheimer","tag-bar-ilan","tag-cerveau","tag-chercheur","tag-experience","tag-maladie","tag-neurones","tag-recherche","tag-vaccin"],"better_featured_image":{"id":162271,"alt_text":"Brain 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