{"id":89330,"date":"2015-04-23T13:06:27","date_gmt":"2015-04-23T10:06:27","guid":{"rendered":"http:\/\/kinsta.unitedwithisrael.org\/?p=89330"},"modified":"2015-04-23T13:06:27","modified_gmt":"2015-04-23T10:06:27","slug":"israelies-descubren-proteinas-que-destruyen-el-cancer","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/israelies-descubren-proteinas-que-destruyen-el-cancer\/","title":{"rendered":"Israel\u00edes descubren prote\u00ednas que destruyen el c\u00e1ncer"},"content":{"rendered":"
\n

Una nueva investigaci\u00f3n del ganador del Premio Nobel Prof. Aaron Ciechanover de un laboratorio de Haifa ha descubierto dos prote\u00ednas que suprimen tumores cancerosos.<\/em><\/strong><\/p>\n

En el estudio, publicado en la revista Cell, Ciechanover y sus colegas en el Technion \u2013 Instituto Tecnol\u00f3gico de Israel, muestran que los tejidos cancerosos fueron reprimidos considerablemente despu\u00e9s de ser tratados con una alta concentraci\u00f3n de las prote\u00ednas, que normalmente est\u00e1n vinculadas a un proceso inflamatorio en el cuerpo.<\/p>\n

Ciechanover, miembro del profesorado de la Facultad de Medicina del Technion, gan\u00f3 el Premio Nobel de Qu\u00edmica en 2004, junto con Avram Hershko, tambi\u00e9n del Technion, y el bi\u00f3logo estadounidense Irwin Rose, por su descubrimiento del proceso de ubiquitina – un sistema celular responsable de descomponer prote\u00ednas da\u00f1adas que pueden da\u00f1ar las c\u00e9lulas o tejidos.<\/p>\n

Este nuevo estudio fue dirigido por la investigadora Dra. Yelena Kravtsova-Ivantsiv, con la participaci\u00f3n de los becarios de investigaci\u00f3n y los m\u00e9dicos de los centros m\u00e9dicos Rambam, Carmel y Hadassah.<\/p>\n

La prote\u00edna \u00abDr. Jekyll y Mr. Hyde\u00bb<\/p>\n

El estudio se centr\u00f3 en dos prote\u00ednas. La primera es p50, que se produce en muchas c\u00e9lulas del organismo y se reconoce como un factor que estimula la inflamaci\u00f3n – y que ha demostrado ser un factor en numerosos estudios de c\u00e1ncer. La p50 es producida por otra prote\u00edna llamada NF-kB, que fue descubierta hace casi 30 a\u00f1os y se ha relacionado en numerosos estudios del desarrollo de neoplasias malignas en la pr\u00f3stata, mama, pulm\u00f3n, cabeza y cuello, colon, cerebro, y muchos \u00f3rganos m\u00e1s. La segunda prote\u00edna se llama KPC1, y, tambi\u00e9n est\u00e1 implicada en la producci\u00f3n de p50.<\/p>\n

Lo que este nuevo estudio ha revelado por primera vez es que, en altas concentraciones, p50 es capaz de tener el\u00a0efecto opuesto: la supresi\u00f3n de c\u00e9lulas cancerosas.<\/p>\n<\/div>\n

\n

\u00abLa prote\u00edna p50 es una reminiscencia del personaje literario Dr. Jekyll y Mr. Hyde\u00bb, declar\u00f3 Ciechanover. \u00abEn ciertas situaciones, puede disfrazarse y cambiar su asignaci\u00f3n. Hasta ahora, sab\u00edamos que p50 es una prote\u00edna que se engancha con otra prote\u00edna llamada p65, que la equilibra. Juntas, estas dos prote\u00ednas estimulan el c\u00e1ncer. Pero en este estudio, hemos encontrado que cuando existe una sobre-expresi\u00f3n de la prote\u00edna p50, no tiene nada para conectar, y por lo tanto se conecta a s\u00ed misma. Como resultado, esencialmente \u00abcambia sus manchas\u00bb y suprime tumores cancerosos. Esto se hace mediante la producci\u00f3n de otras prote\u00ednas que se sabe que son supresoras de c\u00e1ncer. Este es un fen\u00f3meno muy interesante que requiere m\u00e1s estudios de seguimiento\u00bb.<\/p>\n

Se inyectaron a tres grupos de ratones diferentes muestras de c\u00e9lulas de c\u00e1ncer de cerebro humanos: un grupo recibi\u00f3 c\u00e9lulas de c\u00e1ncer a la que se hab\u00eda a\u00f1adido c\u00e9lulas KPC1; otro recibi\u00f3 una alta concentraci\u00f3n de p50; y el tercer grupo, c\u00e9lulas que no fueron tratadas.<\/p>\n

En pocas semanas, los ratones que recibieron las c\u00e9lulas no tratadas ten\u00edan tumores grandes; el grupo tratado con las c\u00e9lulas KPC1 ten\u00edan tumores sustancialmente m\u00e1s peque\u00f1os; mientras que el tercer grupo, que hab\u00edan recibido c\u00e9lulas tratadas con una alta concentraci\u00f3n de p50, desarrollaron tumores peque\u00f1os. De esto, los investigadores concluyen que el aumento de la presencia de p50 en los tejidos contribuye a protegerlos de los tumores.<\/p>\n

\u00abTambi\u00e9n hemos encontrado que esto es cierto para los tumores malignos en los tumores del sistema digestivo y de los huesos\u00bb, agreg\u00f3 Ciechanover. Advirti\u00f3 que la investigaci\u00f3n todav\u00eda est\u00e1 en su etapa preliminar y debe continuar por varios a\u00f1os m\u00e1s antes de que las drogas basadas en el descubrimiento puedan producirse.<\/p>\n

Fuente: Aurora<\/p>\n<\/div>\n

Do You Love Israel? Make a Donation - Show Your Support!<\/h2>
\"\"<\/a>

<\/p><\/div>

Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p>

Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p>

Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. Help us fight back!<\/strong><\/a> <\/p>

STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode>

\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"

En el estudio, publicado en la revista Cell, Ciechanover y sus colegas en el Technion \u2013 Instituto Tecnol\u00f3gico de Israel, muestran que los tejidos cancerosos fueron reprimidos considerablemente despu\u00e9s de ser tratados con una alta concentraci\u00f3n de las prote\u00ednas, que normalmente est\u00e1n vinculadas a un proceso inflamatorio en el cuerpo.<\/p>\n","protected":false},"author":47,"featured_media":87065,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[211],"tags":[12078,12079,12077],"class_list":["post-89330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-luz-para-las-naciones","tag-cancer-es","tag-investigacion-israeli","tag-proteinas-que-destruyen-el-cancer"],"better_featured_image":{"id":87065,"alt_text":"Cancer cells","caption":"cancer cells (Shutterstock)","description":"","media_type":"image","media_details":{"width":1000,"height":667,"file":"2015\/04\/shutterstock_181508288.jpg","sizes":{"thumbnail":{"file":"shutterstock_181508288-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.5% (37 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-150x150.jpg"},"medium":{"file":"shutterstock_181508288-300x200.jpg","width":300,"height":200,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.8% (142 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-300x200.jpg"},"uwi-full-width":{"file":"shutterstock_181508288-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.1% (73 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-780x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_181508288-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.3% (222 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_181508288-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.7% (102 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_181508288-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.9% (112 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_181508288-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_181508288-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_181508288-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.5% (61 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-250x170.jpg"},"uwi-email":{"file":"shutterstock_181508288-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.4% (36 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_181508288-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.1% (103 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_181508288-1000x640.jpg","width":1000,"height":640,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 0.3% (360 B)","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-1000x640.jpg"},"uwi-full-width-video":{"file":"shutterstock_181508288-780x520.jpg","width":780,"height":520,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-780x520.jpg"},"uwi-featured-carousel-video":{"file":"shutterstock_181508288-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-890x400.jpg"},"uwi-featured-content-video":{"file":"shutterstock_181508288-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-290x160.jpg"},"uwi-content-loop-video":{"file":"shutterstock_181508288-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-190x190.jpg"},"uwi-category_list-video":{"file":"shutterstock_181508288-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-180x100.jpg"},"uwi-tiny-video":{"file":"shutterstock_181508288-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-40x40.jpg"},"uwi-email-featured-video":{"file":"shutterstock_181508288-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-250x170.jpg"},"uwi-email-video":{"file":"shutterstock_181508288-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-200x140.jpg"},"uwi-iphone-video":{"file":"shutterstock_181508288-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-960x640.jpg"},"uwi-iphone-x2-video":{"file":"shutterstock_181508288-1000x640.jpg","width":1000,"height":640,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-1000x640.jpg"},"post-thumbnail":{"file":"shutterstock_181508288-125x125.jpg","width":125,"height":125,"mime-type":"image\/jpeg","ewww_image_optimizer":"No savings","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288-125x125.jpg"}},"image_meta":{"aperture":0,"credit":"","camera":"","caption":"","created_timestamp":0,"copyright":"","focal_length":0,"iso":0,"shutter_speed":0,"title":"","orientation":0},"ewww_image_optimizer":"Reduced by 7.7% (53.9 kB)"},"post":87048,"source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2015\/04\/shutterstock_181508288.jpg"},"aioseo_notices":[],"distributor_meta":false,"distributor_terms":false,"distributor_media":false,"distributor_original_site_name":"Unidos con Israel","distributor_original_site_url":"https:\/\/kinsta.unitedwithisrael.org\/es\/","push-errors":false,"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/posts\/89330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/users\/47"}],"replies":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/comments?post=89330"}],"version-history":[{"count":0,"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/posts\/89330\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/media\/87065"}],"wp:attachment":[{"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/media?parent=89330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/categories?post=89330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kinsta.unitedwithisrael.org\/es\/wp-json\/wp\/v2\/tags?post=89330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}