{"id":442850,"date":"2022-12-08T13:14:07","date_gmt":"2022-12-08T13:14:07","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=442850"},"modified":"2022-12-08T16:14:07","modified_gmt":"2022-12-08T13:14:07","slug":"investigadores-israelies-descubrieron-tres-farmacos-comunes-que-pueden-reducir-el-riesgo-de-metastasis-tras-un-cancer-de-colon-o-recto","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/investigadores-israelies-descubrieron-tres-farmacos-comunes-que-pueden-reducir-el-riesgo-de-metastasis-tras-un-cancer-de-colon-o-recto\/","title":{"rendered":"Investigadores israel\u00edes descubrieron tres f\u00e1rmacos comunes que pueden reducir el riesgo de met\u00e1stasis tras un c\u00e1ncer de colon o recto"},"content":{"rendered":"<p class=\"lead\"><strong><em>Investigadores israel\u00edes descubrieron que dos f\u00e1rmacos disponibles en todas las farmacias para bajar la tensi\u00f3n arterial y reducir la ansiedad y otro utilizado para prevenir el dolor y la inflamaci\u00f3n reducen significativamente el riesgo de desarrollar met\u00e1stasis tras una operaci\u00f3n de c\u00e1ncer de colon y recto.<\/em><\/strong><\/p>\n<p>Fuente: Aurora<\/p>\n<p>El descubrimiento, realizado en la Universidad de Tel Aviv (TAU) y probado en pacientes del Centro M\u00e9dico Sheba de Tel Hashomer, tambi\u00e9n descubri\u00f3 que los f\u00e1rmacos minimizaban la ansiedad y la reacci\u00f3n al estr\u00e9s. El tratamiento cl\u00ednico -el primero de este tipo- comienza cinco d\u00edas antes de la operaci\u00f3n y dura s\u00f3lo 20 d\u00edas, con efectos adversos m\u00ednimos o nulos.<\/p>\n<p>El estudio, en el que participaron 34 pacientes tratados en Sheba, demostr\u00f3 que, cinco a\u00f1os despu\u00e9s de la operaci\u00f3n, s\u00f3lo una octava parte (12,5%) de los pacientes quir\u00fargicos que recibieron los f\u00e1rmacos desarrollaron met\u00e1stasis cancerosas, frente a la mitad del grupo de control.<\/p>\n<p>La investigaci\u00f3n fue dirigida por el Prof. Shamgar Ben-Eliyahu, de la Facultad Sagol de Neurociencia y la Facultad de Ciencias Psicol\u00f3gicas de la TAU, y el Prof. Oded Zamora, de la Facultad Sackler de Medicina de la TAU.<\/p>\n<p>Los resultados se publicaron en el European Journal of Surgical Oncology con el t\u00edtulo \u00abEffect of perioperative COX-2 and beta-adrenergic inhibition on 5-year disease-free-survival in colorectal cancer: A pilot randomized controlled Colorectal Metastasis Prevention Trial (COMPIT)\u00bb (Efecto de la inhibici\u00f3n perioperatoria de COX-2 y beta-adren\u00e9rgica sobre la supervivencia sin enfermedad a 5 a\u00f1os en el c\u00e1ncer colorrectal: Un ensayo piloto aleatorizado y controlado de prevenci\u00f3n de la met\u00e1stasis colorrectal -COMPIT-).<\/p>\n<p>Simult\u00e1neamente se public\u00f3 en Nature Reviews Cancer un resumen de la teor\u00eda y los principios subyacentes a la investigaci\u00f3n titulado \u00abEstr\u00e9s y c\u00e1ncer: mecanismos, significado y futuras direcciones\u00bb.<\/p>\n<p>Aunque la cirug\u00eda para extirpar los tumores primarios es el pilar de todos los tratamientos contra el c\u00e1ncer, el riesgo de met\u00e1stasis tras la extirpaci\u00f3n del tumor se estima en un 35% entre los pacientes con c\u00e1ncer de colon, con mayor riesgo en los que se encuentran en estadios m\u00e1s avanzados de la enfermedad.<\/p>\n<p>\u00abEl estr\u00e9s durante el periodo de espera para la intervenci\u00f3n quir\u00fargica, las reacciones de estr\u00e9s e inflamaci\u00f3n que produce el organismo durante la propia cirug\u00eda, el periodo de recuperaci\u00f3n f\u00edsica y, por \u00faltimo, la ansiedad posterior por la reaparici\u00f3n del c\u00e1ncer tienen un efecto adverso en la capacidad del organismo para combatir los procesos metast\u00e1sicos\u00bb, explic\u00f3 Ben-Eliyahu.<\/p>\n<p>Estas condiciones mentales y fisiol\u00f3gicas \u00abcrean respuestas inflamatorias de estr\u00e9s, que provocan una amplia liberaci\u00f3n de hormonas de las familias de las prostaglandinas y las catecolaminas. Estas hormonas suprimen la actividad inmunitaria anti metast\u00e1sica y, por tanto, favorecen el desarrollo de met\u00e1stasis\u00bb, expres\u00f3 Ben-Eliyahu.<\/p>\n<p>\u00abAdem\u00e1s, estas hormonas ayudan directamente a las c\u00e9lulas cancerosas que permanecen en el cuerpo incluso despu\u00e9s de la cirug\u00eda: debido a la exposici\u00f3n a estas hormonas, el tejido canceroso se vuelve m\u00e1s agresivo y metast\u00e1sico. La buena noticia es que sabemos c\u00f3mo tratar tanto el estr\u00e9s como la inflamaci\u00f3n utilizando medicamentos ya disponibles\u00bb, destac\u00f3 el profesor.<\/p>\n<p>Los investigadores de la TAU administraron a 34 pacientes con c\u00e1ncer de colon dos f\u00e1rmacos: propranolol (Darlin), que se utiliza para bajar la tensi\u00f3n arterial y reducir la ansiedad, y etodolac (Etofan), empleado para prevenir el dolor y la inflamaci\u00f3n. Diecis\u00e9is pacientes elegidos al azar tomaron la medicaci\u00f3n despu\u00e9s de la operaci\u00f3n en Sheba durante muy poco tiempo.<\/p>\n<p>Los otros 18 pacientes del grupo de control recibieron f\u00e1rmacos placebo. Cinco a\u00f1os despu\u00e9s, nueve de los 18 pacientes que recibieron el placebo (50%) desarrollaron met\u00e1stasis cancerosas, frente a dos de los 16 pacientes que tomaron Darlin y Etofen (12,5%).<\/p>\n<p>\u00abAunque a los cinco a\u00f1os de la operaci\u00f3n la significaci\u00f3n estad\u00edstica es clara, necesitamos realizar estudios cl\u00ednicos m\u00e1s amplios. Nuestro tratamiento redujo los marcadores de met\u00e1stasis en el tejido tumoral y las posibilidades de recidiva del c\u00e1ncer. Buscamos deliberadamente los f\u00e1rmacos m\u00e1s seguros y baratos capaces de reducir la respuesta estresante-inflamatoria del organismo a la cirug\u00eda, con el fin de salvar vidas\u00bb, a\u00f1adi\u00f3 Ben-Eliyahu.<\/p>\n<p>Con respecto a los resultados, el profesor se\u00f1al\u00f3 que \u00bbsuena demasiado bueno para ser cierto, pero se obtuvieron resultados similares en tejido de c\u00e1ncer de mama en un estudio que realizamos en 2017. Debido al peque\u00f1o n\u00famero de sujetos en ambos estudios, es imposible estimar con precisi\u00f3n la magnitud del efecto beneficioso, pero los efectos son estad\u00edsticamente significativos, lo que significa que no son accidentales\u00bb.<\/p>\n<p>Ben-Eliyahu tambi\u00e9n detall\u00f3 que algunos m\u00e9dicos desconf\u00edan de los efectos de las reacciones inflamatorias provocadas por el estr\u00e9s, en particular las derivadas de factores psicol\u00f3gicos como la espera de una intervenci\u00f3n quir\u00fargica o el miedo a que la enfermedad se extienda. Otro problema se refiere a la financiaci\u00f3n de los estudios cl\u00ednicos.<\/p>\n<p>\u00abHay que tener en cuenta que las empresas farmac\u00e9uticas no tienen ning\u00fan incentivo financiero para apoyar estos estudios. Nuestros medicamentos no est\u00e1n patentados; son seguros, baratos y se administran en un tratamiento breve que dura s\u00f3lo unos d\u00edas. Las empresas farmac\u00e9uticas buscan patentes para medicamentos caros y prefieren que el paciente dependa del f\u00e1rmaco el resto de su vida\u00bb, advirti\u00f3 el director de la investigaci\u00f3n.<\/p>\n<p>\u00abPor desgracia, las principales fundaciones cient\u00edficas de Israel no financian investigaciones cl\u00ednicas sobre f\u00e1rmacos, dando por sentado que las financiar\u00e1n las empresas farmac\u00e9uticas. Intentamos salvar vidas sin beneficio econ\u00f3mico y recibimos apoyo financiero de varias fuentes israel\u00edes e internacionales, pero son insuficientes para grandes estudios cl\u00ednicos\u00bb, agreg\u00f3.<\/p>\n<p>Ben-Eliyahu espera que se encuentre financiaci\u00f3n para un estudio cl\u00ednico a gran escala, con la intenci\u00f3n de reclutar a cientos de pacientes de c\u00e1ncer de colon y recto en Israel, \u00abporque sin una investigaci\u00f3n de este tipo no podremos persuadir al estamento m\u00e9dico de la eficacia del tratamiento\u00bb, concluy\u00f3.<\/p>\n<non-auwi><ad-shortcode><div style=\"margin-top:20px;display:block\"><a href=\"https:\/\/donate.unitedwithisrael.org\/donate\/G1S\/?a=uwi_es_art_bnr_atk\"><img decoding=\"async\" class=\"no-border\" style=\"padding:0;\" src=\"https:\/\/unitedwithisrael.org\/wp-content\/uploads\/2015\/11\/ad_890x100_es.jpg\" alt=\"Donate to Israel\" \/><\/a><\/div><\/ad-shortcode><\/non-auwi>\n<shortcode  style=\"display:block\" ><div class=\"cta-boxed\"><h2>Do You Love Israel? Make a Donation - Show Your Support!<\/h2><div class=\"wp-caption alignright\" style=\"width: 260px\"><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\"><img decoding=\"async\" class=\"size-medium\" src=\"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2022\/06\/shutterstock_1528562331.jpeg\" alt=\"\" width=\"260\"><\/a><p class=\"wp-caption-text\"><\/p><\/div><p><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p><p> Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p><p> Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. <a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Help us fight back!<\/strong><\/a>  <\/p> <p style=\"text-align: left;\"><strong><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\">STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode><non-auwi><ad-shortcode><div style=\"margin-top:20px;display:block\"><a href=\"https:\/\/donate.unitedwithisrael.org\/donate\/G1S\/?a=uwi_es_art_bnr_atk\"><img decoding=\"async\" class=\"no-border\" style=\"padding:0;\" src=\"https:\/\/unitedwithisrael.org\/wp-content\/uploads\/2015\/11\/ad_890x100_es.jpg\" alt=\"Donate to Israel\" \/><\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"<p>Investigadores israel\u00edes descubrieron que dos f\u00e1rmacos disponibles en todas las farmacias para bajar la tensi\u00f3n arterial y reducir la ansiedad y otro utilizado para prevenir el dolor y la inflamaci\u00f3n reducen significativamente el riesgo de desarrollar met\u00e1stasis tras una operaci\u00f3n de c\u00e1ncer de colon y recto.<\/p>\n","protected":false},"author":47,"featured_media":261290,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[211],"tags":[39478],"class_list":["post-442850","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-luz-para-las-naciones","tag-cancer-de-colon-es"],"better_featured_image":{"id":261290,"alt_text":"","caption":"(Shutterstock)","description":"","media_type":"image","media_details":{"width":1000,"height":667,"file":"2015\/11\/shutterstock_296906015.jpg","sizes":{"thumbnail":{"file":"shutterstock_296906015-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","ewww_image_optimizer":"Reduced by 5.0% 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