{"id":442222,"date":"2022-11-28T13:25:38","date_gmt":"2022-11-28T13:25:38","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=442222"},"modified":"2022-11-28T16:25:38","modified_gmt":"2022-11-28T13:25:38","slug":"un-novedoso-desarrollo-que-permite-la-extirpacion-de-tumores-sin-cirugia","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/un-novedoso-desarrollo-que-permite-la-extirpacion-de-tumores-sin-cirugia\/","title":{"rendered":"Un novedoso desarrollo que permite la extirpaci\u00f3n de tumores sin cirug\u00eda"},"content":{"rendered":"

Una combinaci\u00f3n de ultrasonido y nanoburbujas permite que los tumores cancerosos sean destruidos, eliminando la necesidad de tratamientos invasivos.<\/strong><\/em><\/p>\n

(Comunicado del portavoz de la Universidad de Tel Aviv)<\/p>\n

Una nueva tecnolog\u00eda desarrollada en la Universidad de Tel Aviv, hace posible la destrucci\u00f3n de tumores cancerosos de una manera selectiva, mediante una combinaci\u00f3n de ultrasonido y la inyecci\u00f3n de nanoburbujas en el flujo sangu\u00edneo. Seg\u00fan el equipo de investigaci\u00f3n, a diferencia de los m\u00e9todos de tratamiento invasivos o la inyecci\u00f3n de microburbujas dentro del propio tumor, esta \u00faltima tecnolog\u00eda permite la destrucci\u00f3n del tumor de una manera no invasiva.<\/p>\n

El estudio fue realizado bajo la direcci\u00f3n del estudiante de doctorado Mik Bismuth del laboratorio de la Dra. Tali Ilovitsh del Departamento de Ingenier\u00eda Biom\u00e9dica de la Universidad de Tel Aviv, en colaboraci\u00f3n con el Dr. Dov Hershkovitz del Departamento de Patolog\u00eda. Tambi\u00e9n particip\u00f3 en el estudio, la Prof. Agata Exner, de la Universidad Case Western Reserve de Cleveland. El estudio fue publicado en la revista Nanoscale.<\/p>\n

La Dra. Tali Ilovitsh, se\u00f1ala: \u201cNuestra nueva tecnolog\u00eda lo hace posible, de una forma relativamente simple, inyectar nanoburbujas en el flujo sangu\u00edneo, que luego se concentran en el \u00e1rea del tumor canceroso. Tras ello, utilizando un ultrasonido de baja frecuencia, explotamos las nanoburbujas y por consiguiente, el tumor\u201d.<\/p>\n

Los investigadores explican que actualmente, el m\u00e9todo predominante de tratamiento del c\u00e1ncer es la extirpaci\u00f3n quir\u00fargica del tumor, en combinaci\u00f3n con tratamientos complementarios como la quimioterapia y la inmunoterapia. El ultrasonido terap\u00e9utico para destruir el tumor canceroso es una alternativa no invasiva a la cirug\u00eda.<\/p>\n

Este m\u00e9todo tiene tanto ventajas como desventajas. Por un lado, permite un tratamiento localizado y focalizado; el uso de ultrasonido de alta intensidad puede producir efectos t\u00e9rmicos o mec\u00e1nicos al suministrar una poderosa energ\u00eda ac\u00fastica a un punto central con una elevada precisi\u00f3n espacio-temporal. Este m\u00e9todo ha sido utilizado para el tratamiento eficaz de tumores s\u00f3lidos en el interior del cuerpo. Adem\u00e1s, permite tratar a pacientes que no son aptos para la cirug\u00eda de resecci\u00f3n del tumor. La desventaja, no obstante, es que el calor y la alta intensidad de las ondas de ultrasonido pueden da\u00f1ar los tejidos pr\u00f3ximos al tumor.<\/p>\n

En el estudio actual, la Dra. Ilovitsh y su equipo trataron de superar este problema. En el experimento, en el que utilizaron un modelo animal, los investigadores pudieron destruir el tumor al inyectar nanoburbujas en el flujo sangu\u00edneo (contrariamente a lo que hab\u00eda sido utilizado hasta ahora, que era la inyecci\u00f3n local de microburbujas en el propio tumor), en combinaci\u00f3n con ondas de ultrasonido de baja frecuencia, con m\u00ednimos efectos no deseados.<\/p>\n

La Dra. Ilovitsh afirma: \u201cLa combinaci\u00f3n de nanoburbujas y las ondas de ultrasonido de baja frecuencia proporciona una focalizaci\u00f3n m\u00e1s espec\u00edfica en el \u00e1rea del tumor, y reduce la toxicidad no deseada. La aplicaci\u00f3n de la baja frecuencia a las nanoburbujas genera su inflamaci\u00f3n y explosi\u00f3n extremas, incluso a baja presi\u00f3n. Esto permite realizar la destrucci\u00f3n mec\u00e1nica de los tumores, a umbrales de baja presi\u00f3n. Nuestro m\u00e9todo tiene las ventajas del ultrasonido, en el sentido de que es seguro, rentable y cl\u00ednicamente disponible, y adem\u00e1s, el uso de nanoburbujas facilita la localizaci\u00f3n de los tumores porque pueden ser observados con la ayuda de im\u00e1genes de ultrasonido\u201d.<\/p>\n

La Dra. Ilovitsh, agrega diciendo que el uso de ultrasonido de baja frecuencia tambi\u00e9n aumenta la profundidad de la penetraci\u00f3n, minimiza la distorsi\u00f3n y la atenuaci\u00f3n, y ampl\u00eda el punto focal. \u201cEsto puede ayudar en el tratamiento de los tumores que est\u00e1n localizados profundamente en el cuerpo, y adem\u00e1s, facilitar el tratamiento de tumores de un volumen mayor. El experimento fue realizado en un rat\u00f3n modelo con tumor de c\u00e1ncer de mama, pero es probable que el tratamiento tambi\u00e9n sea eficaz con otros tipos de tumores, y en el futuro, tambi\u00e9n en los humanos\u201d.<\/p>\n

Keren Primor Cohen, Directora General de Ramot, se\u00f1ala: \u201cLa empresa de transferencia tecnol\u00f3gica Ramot, de la Universidad de Tel Aviv, implement\u00f3 diversas patentes para proteger esta tecnolog\u00eda y su aplicaci\u00f3n. Creemos en el potencial comercial de esta tecnolog\u00eda innovadora en el tratamiento del c\u00e1ncer y estamos en contacto con diversas compa\u00f1\u00edas l\u00edderes en Israel y en el exterior, a fin de promocionarlo\u201d.<\/p>\n

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Una combinaci\u00f3n de ultrasonido y nanoburbujas permite que los tumores cancerosos sean destruidos, eliminando la necesidad de tratamientos 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