{"id":441862,"date":"2022-11-23T09:44:07","date_gmt":"2022-11-23T09:44:07","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=441862"},"modified":"2022-11-23T12:44:07","modified_gmt":"2022-11-23T09:44:07","slug":"nueva-esperanza-para-pacientes-con-perdida-osea-severa","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/nueva-esperanza-para-pacientes-con-perdida-osea-severa\/","title":{"rendered":"Nueva esperanza para pacientes con p\u00e9rdida \u00f3sea severa"},"content":{"rendered":"

Los investigadores indujeron una regeneraci\u00f3n \u00f3sea con un hidrogel especial que imita el entorno natural del hueso.<\/em><\/strong><\/p>\n

(Comunicado de la portavoz de la Universidad de Tel Aviv)<\/p>\n

Una tecnolog\u00eda innovadora desarrollada en la Universidad de Tel Aviv, permitir\u00e1 la regeneraci\u00f3n \u00f3sea para corregir importantes defectos \u00f3seos por medio de un hidrogel especial. Tras las exitosas pruebas en un modelo animal, los investigadores planean ahora avanzar con los ensayos cl\u00ednicos.<\/p>\n

El innovador estudio fue realizado por expertos de la Facultad de Odontolog\u00eda Maurice y Gabriela Goldschleger de la Universidad de Tel Aviv, dirigidos por la profesora Lihi Adler-Abramovich y la Dra. Michal Halperin-Sternfeld, en cooperaci\u00f3n con el Prof. Itzjak Binderman, la Dra. Rachel Sarig y la Dra. Moran Aviv, e investigadores de la Universidad de Michigan, en Ann Arbor. El trabajo fue publicado en la revista Journal of Clinical Periodontology.<\/p>\n

La Prof. Adler-Abramovich se\u00f1al\u00f3: \u201cLos peque\u00f1os defectos de huesos, como fracturas, se curan espont\u00e1neamente con la restauraci\u00f3n del cuerpo del tejido \u00f3seo perdido. El problema comienza en el caso de importantes defectos \u00f3seos. En numerosos casos, cuando hay una p\u00e9rdida sustancial del hueso, como consecuencia de la resecci\u00f3n de un tumor (eliminado por cirug\u00eda), un traumatismo f\u00edsico, la extracci\u00f3n de un diente, una enfermedad de las enc\u00edas o una inflamaci\u00f3n alrededor de los implantes dentales, el hueso es incapaz de regenerarse. En el estudio actual, hemos desarrollado un hidrogel que imita las sustancias naturales de la matriz extracelular de los huesos, estimulando el crecimiento del hueso y reactivando el sistema inmunol\u00f3gico a fin de acelerar el proceso de curaci\u00f3n\u201d.<\/p>\n

Los investigadores explican que la matriz extracelular es la sustancia que rodea nuestras c\u00e9lulas, les proporciona un apoyo estructural. Cada tipo de tejido de nuestro cuerpo tiene una matriz extracelular espec\u00edfica, formada por las sustancias adecuadas a las propiedades mec\u00e1nicas correctas. El nuevo hidrogel tiene una estructura fibrilar que imita la de la matriz extracelular del hueso natural. Adem\u00e1s, es r\u00edgido, de modo que le permite a las c\u00e9lulas del paciente diferenciarse en c\u00e9lulas formadoras de hueso.<\/p>\n

\u201cComo se prev\u00e9, la matriz extracelular de nuestros huesos es bastante r\u00edgida\u201d, dice la profesora Adler-Abramovich. \u201cEn nuestro estudio produjimos un hidrogel que imita esta matriz especifica tanto en sus propiedades qu\u00edmicas como f\u00edsicas. En el plano manom\u00e9trico, la c\u00e9lula puede adherirse al gel, obteniendo soporte estructural y recibiendo las se\u00f1ales mec\u00e1nicas relevantes de las fibras. En primer lugar, a fin de verificar estas propiedades, cultivamos c\u00e9lulas en un modelo 3D del gel. Luego, examinamos el impacto del hidrogel en animales modelo con importantes defectos \u00f3seos, que no pod\u00edan curarse espont\u00e1neamente. Los monitoreamos durante dos meses con varios m\u00e9todos, incluida la micro tomograf\u00eda computarizada. Para nuestro encanto, los defectos \u00f3seos fueron totalmente corregidos mediante la regeneraci\u00f3n, con los huesos recuperando su grosor original, y generando nuevos vasos sangu\u00edneos\u201d.<\/p>\n

Seg\u00fan la profesora Adler-Abramovich, el gel innovador tiene aplicaciones cl\u00ednicas extensivas tanto en la medicina ortop\u00e9dica como en la dental: \u201cCuando perdemos dientes debido a un da\u00f1os importantes o infecciones bacterianas, el tratamiento est\u00e1ndar son los implantes dentales. No obstante, los implantes deben estar anclados en una cantidad suficiente de hueso, y cuando la perdida \u00f3sea es muy sustancial, los m\u00e9dicos implantan hueso adicional de una parte sana del cuerpo-un procedimiento m\u00e9dico complejo. Otra opci\u00f3n es agregar sustitutos \u00f3seos ya sea de origen humano o animal, pero estos podr\u00edan generar una respuesta inmunitaria. Espero que en el futuro el hidrogel que hemos desarrollado habr\u00e1 de permitir una restauraci\u00f3n \u00f3sea m\u00e1s r\u00e1pida, m\u00e1s segura y m\u00e1s simple\u201d.<\/p>\n

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Los investigadores indujeron una regeneraci\u00f3n \u00f3sea con un hidrogel especial que imita el entorno natural del hueso.<\/p>\n","protected":false},"author":47,"featured_media":441863,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[211],"tags":[44886],"class_list":["post-441862","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-luz-para-las-naciones","tag-perdida-osea"],"better_featured_image":{"id":441863,"alt_text":"","caption":"Huesos 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