{"id":420779,"date":"2022-03-30T09:06:39","date_gmt":"2022-03-30T09:06:39","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=420779"},"modified":"2022-03-30T12:06:39","modified_gmt":"2022-03-30T09:06:39","slug":"universidad-ben-gurion-la-investigacion-del-arnm-puede-conducir-a-mejores-medicamentos-contra-el-cancer","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/universidad-ben-gurion-la-investigacion-del-arnm-puede-conducir-a-mejores-medicamentos-contra-el-cancer\/","title":{"rendered":"Universidad Ben-Guri\u00f3n: La investigaci\u00f3n del ARNm puede conducir a mejores medicamentos contra el c\u00e1ncer"},"content":{"rendered":"

Casi todo el mundo ha o\u00eddo hablar del ARN mensajero, gracias a las vacunas contra el Covid-19 de Pfizer y Moderna basadas en esa tecnolog\u00eda. Pero antes de que se utilizara para el coronavirus, se realizaron investigaciones sobre c\u00f3mo podr\u00eda combatir el c\u00e1ncer. Ahora, investigadores de la Universidad Ben-Guri\u00f3n del N\u00e9guev (BGU) descubrieron una conexi\u00f3n clave entre el ARNm, las prote\u00ednas pept\u00eddicas y la progresi\u00f3n tumoral.<\/em><\/strong><\/p>\n

Por: Brian Blum<\/a>, Israel21c<\/p>\n

El ARN mensajero codifica diferentes prote\u00ednas, cada una con una funci\u00f3n \u00fanica. Hay p\u00e9ptidos \u201clargos\u201d y \u201ccortos\u201d. Hasta ahora, los cient\u00edficos no estaban seguros de si los p\u00e9ptidos cortos ten\u00edan alguna funci\u00f3n biol\u00f3gica.<\/p>\n

La profesora Etta Livneh del Departamento de Inmunolog\u00eda, Microbiolog\u00eda y Gen\u00e9tica Shraga Segal de la BGU demostr\u00f3 que los p\u00e9ptidos cortos tienen un papel muy importante: como inhibidores de la cinasa que pueden retrasar el crecimiento y la invasi\u00f3n de tumores, la supervivencia de las c\u00e9lulas cancerosas y la met\u00e1stasis.<\/p>\n

Las prote\u00ednas (y las prote\u00ednas quinasas en particular) propagan se\u00f1ales que llevan instrucciones a las c\u00e9lulas y dictan el destino celular. Hay m\u00e1s de 500 quinasas diferentes en el cuerpo humano.<\/p>\n

Con el c\u00e1ncer, una quinasa le dice err\u00f3neamente a las c\u00e9lulas que se dividan y reproduzcan de manera r\u00e1pida e incontrolable. Pero si se puede inhibir una quinasa, se deber\u00eda bloquear la proliferaci\u00f3n de c\u00e9lulas cancerosas.<\/p>\n

Y eso es \u201csolo la punta del iceberg\u201d, explic\u00f3 Livneh, cuyo descubrimiento tard\u00f3 una d\u00e9cada en realizarse. \u201cAhora que sabemos que al menos algunos p\u00e9ptidos tienen una funci\u00f3n biol\u00f3gica, podemos comenzar a descubrir las funciones de muchos m\u00e1s\u201d.<\/p>\n

Los inhibidores de la quinasa ya son una de las \u00e1reas que despiertan m\u00e1s inter\u00e9s en la investigaci\u00f3n del c\u00e1ncer y, en algunos casos, reemplazan a la quimioterapia. La investigaci\u00f3n de Livneh permitir\u00e1 a los cient\u00edficos comprender mejor c\u00f3mo controlar esta tecnolog\u00eda vital para combatir el c\u00e1ncer.<\/p>\n

Los colaboradores de Livneh incluyen al Prof. Esti Yeger-Lotem del Departamento de Bioqu\u00edmica Cl\u00ednica y Farmacolog\u00eda de BGU y al Prof. Moshe Elkabets en la Facultad de Ciencias de la Salud. Investigadores adicionales incluyen a Divya Ram Jayaram, Sigal Frost, Chanan Argov, Vijayasteltar Belsamma Liju, Nikhil Ponnoor Anto, Amitha Muraleedharan, Assaf Ben-Ari, Rose Sinay, Ilan Smoly, Ofra Novoplansky, Noah Isakov, Dr. Debra Toiber y Chen Keasar.<\/p>\n

La investigaci\u00f3n fue apoyada por una subvenci\u00f3n de la Fundaci\u00f3n de Ciencias de Israel y publicada en la Academia Nacional de Ciencias de los Estados Unidos.<\/p>\n

Fuente: israel21c.org<\/p>\n

Extra\u00eddo de la p\u00e1gina de Iton Gadol<\/p>\n

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Casi todo el mundo ha o\u00eddo hablar del ARN mensajero, gracias a las vacunas contra el Covid-19 de Pfizer y Moderna basadas en esa tecnolog\u00eda. Pero antes de que se utilizara para el coronavirus, se realizaron investigaciones sobre c\u00f3mo podr\u00eda combatir el c\u00e1ncer.<\/p>\n","protected":false},"author":47,"featured_media":298973,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[211],"tags":[43609,12078,22920],"class_list":["post-420779","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-luz-para-las-naciones","tag-arnm","tag-cancer-es","tag-universidad-ben-gurion"],"better_featured_image":{"id":298973,"alt_text":"Cancer Cells","caption":"(Shutterstock)","description":"Cancer Cells 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