{"id":377859,"date":"2021-01-31T16:56:38","date_gmt":"2021-01-31T13:56:38","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=377859"},"modified":"2021-02-01T10:45:36","modified_gmt":"2021-02-01T07:45:36","slug":"avance-israeli-investigadores-descubren-un-nuevo-objetivo-para-matar-las-celulas-cancerosas","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/avance-israeli-investigadores-descubren-un-nuevo-objetivo-para-matar-las-celulas-cancerosas\/","title":{"rendered":"Avance israel\u00ed: Investigadores descubren un nuevo objetivo para matar las c\u00e9lulas cancerosas"},"content":{"rendered":"<p class=\"lead\"><em><strong><span style=\"vertical-align: inherit;\">Los investigadores de la Universidad de Tel Aviv descubrieron un enfoque novedoso para atacar las c\u00e9lulas cancerosas. <\/span><\/strong><\/em><\/p>\n<p><em><span style=\"vertical-align: inherit;\">Por Yakir Benzion, Unidos con Israel<\/span><\/em><\/p>\n<p><span style=\"vertical-align: inherit;\">Investigadores de la Universidad de Tel Aviv (TAU) han descubierto que el n\u00famero anormal de cromosomas en las c\u00e9lulas cancerosas podr\u00eda llegar a ser el \u00abtal\u00f3n de Aquiles\u00bb de la enfermedad, allanando el camino para que los medicamentos futuros ataquen el punto d\u00e9bil reci\u00e9n descubierto.<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\">Si bien los investigadores han sabido durante d\u00e9cadas sobre el n\u00famero anormal de cromosomas de las c\u00e9lulas cancerosas, una caracter\u00edstica conocida como \u00abaneuploid\u00eda\u00bb, su comprensi\u00f3n de c\u00f3mo la aneuploid\u00eda contribuye al desarrollo y propagaci\u00f3n del c\u00e1ncer ha sido limitada.<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\">Los investigadores de TAU descubrieron el punto cr\u00edtico en el que las c\u00e9lulas cancerosas aneuploides cancerosas son sensibles al da\u00f1o (el punto de control mit\u00f3tico) y la raz\u00f3n de una mayor sensibilidad en esta ubicaci\u00f3n.<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\">Los medicamentos que se dirigen a este mecanismo podr\u00edan representar importantes avances en la medicina personalizada contra el c\u00e1ncer.<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\">Los resultados del estudio dirigido por TAU sugieren que ser\u00e1 posible utilizar la aneuploid\u00eda como marcador biol\u00f3gico para identificar a los pacientes que responder\u00edan mejor a f\u00e1rmacos espec\u00edficos.<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\">El estudio en la Facultad de Medicina Sackler de TAU se realiz\u00f3 en colaboraci\u00f3n con otros seis laboratorios en otros cuatro pa\u00edses y se public\u00f3 la semana pasada en la prestigiosa revista <\/span><em><span style=\"vertical-align: inherit;\">Nature<\/span><\/em><span style=\"vertical-align: inherit;\"> revisada por pares .<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\">Seg\u00fan el Dr. Uri Ben-David, la aneuploid\u00eda es el cambio gen\u00e9tico m\u00e1s com\u00fan en el c\u00e1ncer. Aproximadamente el 90% de los tumores s\u00f3lidos, como el c\u00e1ncer de mama y el c\u00e1ncer de colon, y el 75% de los c\u00e1nceres de sangre son de naturaleza aneuploide.<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\">\u00abDebe enfatizarse que el estudio se realiz\u00f3 en c\u00e9lulas en un cultivo y no en pacientes con c\u00e1ncer\u00bb, dijo el Dr. Ben-David. \u00abPara traducirlo al tratamiento de pacientes con c\u00e1ncer, se deben realizar muchos m\u00e1s estudios de seguimiento. A\u00fan as\u00ed, incluso en esta etapa, est\u00e1 claro que el estudio podr\u00eda tener una serie de implicaciones m\u00e9dicas\u00bb.<\/span><\/p>\n<p><span style=\"vertical-align: inherit;\"><!-- ERROR: El anuncio no est\u00e1 disponible en este momento debido a las restricciones restricciones de programa o geolocalizaci\u00f3n! --><shortcode id=\"corona\"><cta><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/G1s\"><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/G1s\"><img loading=\"lazy\" decoding=\"async\" class=\"no-border alignright size-medium\" src=\"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2020\/03\/shutterstock_1664856475-scaled.jpg\"alt=\"shutterstock_152856233\" width=\"300\" height=\"173\"\/><\/a><h2>ISRAEL, PRIMER PA\u00cdS DEL MUNDO EN VACUNACI\u00d3N<\/h2><p><p><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/G1s\" target=\"_blank\"><strong> Dona al Fondo de ayuda de United with Israel para luchar contra la grave crisis econ\u00f3mica que sufren millones de israel\u00edes <\/strong><\/a>. Israel es el pa\u00eds con un mayor \u00edndice de vacunaci\u00f3n del mundo, por poblaci\u00f3n. El 50% de los israel\u00edes ya se han vacunado.\r\nAhora es el momento de ayudar a los que m\u00e1s quieres.\r\n\r\n<\/p><p> Los israel\u00edes necesitan tu ayuda. Los alimentos y suministros m\u00e9dicos pueden ser escasos. La tasa de desempleo contin\u00faa en un 25%. Comenzamos la crisis con una tasa del 4%\r\n\r\n\u00a0\u00a0<\/p><p>Unidos con Israel agradece al\u00a0 <a href=\"https:\/\/www.genesisprize.org\" target=\"_blank\"><strong>Genesis Prize<\/strong><\/a> por su generoso apoyo.<\/p><p style=\"font-size:18px;\"><strong><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/G1s\" target=\"_blank\">HAZ CLIC AQU\u00cd PARA HACER UNA DONACI\u00d3N<\/a><\/strong><\/p><\/cta><\/shortcode><\/span><\/p>\n<shortcode  style=\"display:block\" ><div class=\"cta-boxed\"><h2>Do You Love Israel? Make a Donation - Show Your Support!<\/h2><div class=\"wp-caption alignright\" style=\"width: 260px\"><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\"><img decoding=\"async\" class=\"size-medium\" src=\"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2022\/06\/shutterstock_1528562331.jpeg\" alt=\"\" width=\"260\"><\/a><p class=\"wp-caption-text\"><\/p><\/div><p><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p><p> Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p><p> Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. <a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\" rel=\"noopener\"><strong>Help us fight back!<\/strong><\/a>  <\/p> <p style=\"text-align: left;\"><strong><a href=\"https:\/\/donate.kinsta.unitedwithisrael.org\/donate\/g4?a=asc\" target=\"_blank\">STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode><non-auwi><ad-shortcode><div style=\"margin-top:20px;display:block\"><a href=\"https:\/\/donate.unitedwithisrael.org\/donate\/G1S\/?a=uwi_es_art_bnr_atk\"><img decoding=\"async\" class=\"no-border\" style=\"padding:0;\" src=\"https:\/\/unitedwithisrael.org\/wp-content\/uploads\/2015\/11\/ad_890x100_es.jpg\" alt=\"Donate to Israel\" \/><\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"<p>Los investigadores de la Universidad de Tel Aviv descubrieron un enfoque novedoso para atacar las c\u00e9lulas cancerosas.<\/p>\n","protected":false},"author":47,"featured_media":377861,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[211],"tags":[],"class_list":["post-377859","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-luz-para-las-naciones"],"better_featured_image":{"id":377861,"alt_text":"","caption":"(Shutterstock)","description":"","media_type":"image","media_details":{"width":1000,"height":500,"file":"2021\/01\/shutterstock_1713509629-e1612115046755-1.jpg","sizes":{"medium":{"file":"shutterstock_1713509629-e1612115046755-1-300x150.jpg","width":300,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-300x150.jpg"},"thumbnail":{"file":"shutterstock_1713509629-e1612115046755-1-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-150x150.jpg"},"medium_large":{"file":"shutterstock_1713509629-e1612115046755-1-768x384.jpg","width":768,"height":384,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-768x384.jpg"},"uwi-full-width":{"file":"shutterstock_1713509629-e1612115046755-1-780x390.jpg","width":780,"height":390,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-780x390.jpg"},"uwi-featured-carousel":{"file":"shutterstock_1713509629-e1612115046755-1-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_1713509629-e1612115046755-1-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_1713509629-e1612115046755-1-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_1713509629-e1612115046755-1-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_1713509629-e1612115046755-1-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_1713509629-e1612115046755-1-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-250x170.jpg"},"uwi-email":{"file":"shutterstock_1713509629-e1612115046755-1-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_1713509629-e1612115046755-1-960x500.jpg","width":960,"height":500,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-960x500.jpg"},"uwi-full-width-video":{"file":"shutterstock_1713509629-e1612115046755-1-779x390.jpg","width":779,"height":390,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-779x390.jpg"},"uwi-fb-share-video":{"file":"shutterstock_1713509629-e1612115046755-1-600x315.jpg","width":600,"height":315,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-600x315.jpg"},"uwi-fb-share":{"file":"shutterstock_1713509629-e1612115046755-1-600x320.jpg","width":600,"height":320,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2021\/01\/shutterstock_1713509629-e1612115046755-1-600x320.jpg"},"uwi-featured-content-video":{"file":"shutterstock_1713509629-e1612115046755-1-289x159.jpg","width":289,"height":159,"mime-type":"image\/jpeg","source_url":"htt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