{"id":314719,"date":"2019-09-12T10:19:07","date_gmt":"2019-09-12T07:19:07","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=314719"},"modified":"2019-09-12T10:19:07","modified_gmt":"2019-09-12T07:19:07","slug":"israel-como-evitar-que-el-melanoma-se-vuelva-letal","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/israel-como-evitar-que-el-melanoma-se-vuelva-letal\/","title":{"rendered":"Israel: C\u00f3mo evitar que el melanoma se vuelva letal"},"content":{"rendered":"

El melanoma es el c\u00e1ncer m\u00e1s temido. Si bien se puede tratar e cuando est\u00e1 bloqueado en la capa externa de la piel, una vez que penetra m\u00e1s profundo y hace met\u00e1stasis en los \u00f3rganos vitales, se vuelve mortal.<\/strong><\/em><\/p>\n

Fuente: es.israel21c.org<\/p>\n

Ahora, un grupo de investigadoras israel\u00edes descubrieron que las c\u00e9lulas grasas desempe\u00f1an un papel clave en esta transformaci\u00f3n y encontraron una forma de bloquearlas.<\/p>\n

El hallazgo respondi\u00f3 a un importante interrogante que preocup\u00f3 a los cient\u00edficos durante a\u00f1os. \u00bfQu\u00e9 hace que el melanoma cambie de forma y se vuelva agresivo? \u00abEl melanoma se vuelve letal cuando se despierta porque envia c\u00e9lulas cancerosas a la capa de piel de la dermis, debajo de la epidermis, y hace met\u00e1stasis en los \u00f3rganos vitales. Bloquear la transformaci\u00f3n del melanoma es uno de los objetivos principales de la investigaci\u00f3n del c\u00e1ncer en la actualidad. Hoy ya sabemos que las c\u00e9lulas grasas est\u00e1n involucradas en este cambio\u00bb, explic\u00f3 la profesora profesor Carmit Levy, de la Universidad de Tel Aviv, que dirigi\u00f3 el estudio junto a su colega Tamar Golan.<\/p>\n

En el estudio, publicado en Science Signaling, los investigadores examinaron docenas de muestras de biopsias tomadas de pacientes con melanoma en el Centro M\u00e9dico Wolfson y el Centro M\u00e9dico de Tel Aviv y observaron c\u00e9lulas grasas cerca de los sitios del tumor.<\/p>\n

\u00abNos preguntamos qu\u00e9 hac\u00edan all\u00ed esas c\u00e9lulas grasas y comenzamos a investigar. Las colocamos en una placa de Petri cerca de las c\u00e9lulas de c\u00e1ncer de piel y seguimos las interacciones entre ellas\u00bb, explicaron las cient\u00edficas, que observaron que las c\u00e9lulas grasas transfieren prote\u00ednas llamadas citocinas \u2013 que afectan la expresi\u00f3n g\u00e9nica- a las c\u00e9lulas del melanoma.<\/p>\n

Sus an\u00e1lisis mostraron que las citocinas reducen la expresi\u00f3n de un gen que a su vez inhibe la expresi\u00f3n de un receptor clave de melanoma, permitiendo as\u00ed que el tumor absorba una alta concentraci\u00f3n de la prote\u00edna beta TGF, que estimula a las c\u00e9lulas de melanoma y las hace agresivas. Pero el proceso result\u00f3 ser reversible.<\/p>\n

Despu\u00e9s de la prueba de la placa de Petri, se realiz\u00f3 otra con modelos de melanoma en ratones y esta arroj\u00f3 resultados similares.<\/p>\n

En la b\u00fasqueda de un posible f\u00e1rmaco basado en el nuevo descubrimiento, los investigadores experimentaron con terapias que inhiben a las citocinas y al TGF beta pero que nunca se hab\u00edan utilizado para tratar el melanoma.<\/p>\n

\u00abEstamos hablando de sustancias que actualmente se est\u00e1n estudiando como posibles tratamientos para el c\u00e1ncer de p\u00e1ncreas. Tambi\u00e9n est\u00e1n en ensayos cl\u00ednicos para el c\u00e1ncer de pr\u00f3stata, mama, ovario y vejiga. Vimos que restringieron el proceso metast\u00e1sico y que el melanoma volvi\u00f3 a un estado relativamente tranquilo y latente\u201d, manifest\u00f3 Golan.<\/p>\n

Levy cree que los hallazgos pueden servir como base para el desarrollo de nuevos medicamentos que detengan la propagaci\u00f3n del melanoma: \u00abEn el futuro, buscamos colaborar con las compa\u00f1\u00edas farmac\u00e9uticas para mejorar el desarrollo del enfoque de prevenci\u00f3n del melanoma metast\u00e1sico\u00bb.<\/p>\n<\/a>

\u00bfEst\u00e1s Unido con Israel? \u00a1DEMU\u00c9STRALO!<\/h2>

\u00bfQuieres hacer algo grande por Israel hoy mismo? Haz una donaci\u00f3n a United with Israel, y ayudar\u00e1s a educar e inspirar a millones de personas en todo el mundo para que apoyen, como tu lo haces, a Israel.\r\n<\/p>

Somos un movimiento mundial que fomenta la unidad y el amor por la Tierra de Israel y el Pueblo Jud\u00edo. Todos los d\u00edas publicamos historias sobre Israel para educar, inspirar y dotar de m\u00e1s recursos a los partidarios de Israel en todo el mundo. Contribuimos a causas vitales como la construcci\u00f3n de refugios antia\u00e9reos y ayudamos a los m\u00e1s necesitados. Las donaciones de los verdaderos amigos de Israel como tu hacen que esto sea posible... as\u00ed que por favor muestra tu apoyo a Israel hoy mismo.<\/p><\/p>

HAZ CLIC AQU\u00cd PARA HACER TU DONACI\u00d3N<\/a><\/strong><\/p><\/cta><\/shortcode>

\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>\n

Do You Love Israel? Make a Donation - Show Your Support!<\/h2>
\"\"<\/a>

<\/p><\/div>

Donate to vital charities<\/strong><\/a> that help protect Israeli citizens and inspire millions around the world to support Israel too! <\/p>

Now more than ever, Israel needs your help to fight and win the war -- including on the battlefield of public opinion. <\/p>

Antisemitism, anti-Israel bias and boycotts are out of control. Israel's enemies are inciting terror and violence against innocent Israelis and Jews around the world. Help us fight back!<\/strong><\/a> <\/p>

STAND WTH ISRAEL - MAKE A DONATION TODAY!<\/a><\/strong><\/p><\/div><\/shortcode>

\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"

Ahora, un grupo de investigadoras israel\u00edes descubrieron que las c\u00e9lulas grasas desempe\u00f1an un papel clave en esta transformaci\u00f3n y encontraron una forma de bloquearlas.<\/p>\n","protected":false},"author":47,"featured_media":291012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[211],"tags":[12078,35735],"class_list":["post-314719","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-luz-para-las-naciones","tag-cancer-es","tag-melanoma-es"],"better_featured_image":{"id":291012,"alt_text":"Melanoma Cancer Cells","caption":"Melanoma Cancer Cells (shutterstock)","description":"Melanoma Cancer 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