{"id":192922,"date":"2017-07-23T14:02:54","date_gmt":"2017-07-23T11:02:54","guid":{"rendered":"https:\/\/kinsta.unitedwithisrael.org\/?p=192922\/"},"modified":"2017-07-23T14:02:54","modified_gmt":"2017-07-23T11:02:54","slug":"asi-se-investiga-en-israel-el-mal-de-alzheimer","status":"publish","type":"post","link":"https:\/\/kinsta.unitedwithisrael.org\/es\/asi-se-investiga-en-israel-el-mal-de-alzheimer\/","title":{"rendered":"As\u00ed se investiga en Israel el mal de Alzheimer"},"content":{"rendered":"

Investigadores revelan la existencia de un mecanismo celular inusual que podr\u00eda fallar en pacientes con el mal de Alzheimer. \u00bfPor qu\u00e9 una c\u00e9lula se tomar\u00eda el trabajo de destruir prote\u00ednas perfectas y recientemente producidas?<\/strong><\/em><\/p>\n

Una nueva investigaci\u00f3n sugiere que este inusual mecanismo celular podr\u00eda, entre otras cosas, fallar en pacientes con el mal de Alzheimer.<\/p>\n

La investigaci\u00f3n fue realizada por el Instituto Weizmann conjuntamente con centros de investigaci\u00f3n en Alemania, y fue publicada en Molecular Cell.<\/p>\n

La Dra. Maya Schuldiner y el estudiante de investigaci\u00f3n Dr. Shai Fuchs del Departamento de Gen\u00e9tica Molecular del Instituto Weizmann, en colaboraci\u00f3n con el Dr. Marius Lemberg y el Dr. Donem Avci de la Universidad de Heidelberg, investigaron la Presenilina, una prote\u00edna humana que se encuentra mutada en una forma familiar de Alzheimer en edad temprana.<\/p>\n

Para investigar el mecanismo de esta prote\u00edna, los cient\u00edficos estudiaron un ancestro de la Presenilina, una prote\u00edna de la levadura que identificaron como Ypf1 (por sus siglas en ingl\u00e9s de \u201cpliegue de la Presenilina de la levadura 1\u201d), que se ha conservado durante la evoluci\u00f3n.<\/p>\n

La remoci\u00f3n de la Ypf1 de las c\u00e9lulas de levadura, result\u00f3 en un incremento excesivo de una prote\u00edna cuya funci\u00f3n es bombear Zinc – un metal esencial – hacia el interior de la c\u00e9lula. Lo extra\u00f1o es que a pesar de la existencia de dos prote\u00ednas que bombean zinc hacia el interior de la c\u00e9lula, s\u00f3lo una fue afectada.<\/p>\n

Seguir leyendo en: https:\/\/latamisrael.com\/mal-de-alzheimer\/<\/p>\n

 <\/p>\n

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\"Donate<\/a><\/div><\/ad-shortcode><\/non-auwi>","protected":false},"excerpt":{"rendered":"

Investigadores revelan la existencia de un mecanismo celular inusual que podr\u00eda fallar en pacientes con el mal de Alzheimer. \u00bfPor qu\u00e9 una c\u00e9lula se tomar\u00eda el trabajo de destruir prote\u00ednas perfectas y recientemente producidas?<\/p>\n","protected":false},"author":47,"featured_media":139601,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[211],"tags":[25578,25579,9575,2928],"class_list":["post-192922","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-luz-para-las-naciones","tag-alzheimer","tag-alzheimer-israel","tag-avances-medicos-en-israel","tag-medicina-israeli"],"better_featured_image":{"id":139601,"alt_text":"Alzheimer's","caption":"(Shutterstock)","description":"","media_type":"image","media_details":{"width":1000,"height":782,"file":"2016\/02\/shutterstock_264060908.jpg","sizes":{"thumbnail":{"file":"shutterstock_264060908-150x150.jpg","width":150,"height":150,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-150x150.jpg"},"medium":{"file":"shutterstock_264060908-300x235.jpg","width":300,"height":235,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-300x235.jpg"},"medium_large":{"file":"shutterstock_264060908-768x601.jpg","width":768,"height":601,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-768x601.jpg"},"uwi-full-width":{"file":"shutterstock_264060908-665x520.jpg","width":665,"height":520,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-665x520.jpg"},"uwi-featured-carousel":{"file":"shutterstock_264060908-890x400.jpg","width":890,"height":400,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-890x400.jpg"},"uwi-featured-content":{"file":"shutterstock_264060908-290x160.jpg","width":290,"height":160,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-290x160.jpg"},"uwi-content-loop":{"file":"shutterstock_264060908-190x190.jpg","width":190,"height":190,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-190x190.jpg"},"uwi-category_list":{"file":"shutterstock_264060908-180x100.jpg","width":180,"height":100,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-180x100.jpg"},"uwi-tiny":{"file":"shutterstock_264060908-40x40.jpg","width":40,"height":40,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-40x40.jpg"},"uwi-email-featured":{"file":"shutterstock_264060908-250x170.jpg","width":250,"height":170,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-250x170.jpg"},"uwi-email":{"file":"shutterstock_264060908-200x140.jpg","width":200,"height":140,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-200x140.jpg"},"uwi-iphone":{"file":"shutterstock_264060908-960x640.jpg","width":960,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-960x640.jpg"},"uwi-iphone-x2":{"file":"shutterstock_264060908-1000x640.jpg","width":1000,"height":640,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-1000x640.jpg"},"uwi-ipad":{"file":"shutterstock_264060908-1000x768.jpg","width":1000,"height":768,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-1000x768.jpg"},"uwi-full-width-video":{"file":"shutterstock_264060908-664x519.jpg","width":664,"height":519,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-664x519.jpg"},"uwi-fb-share-video":{"file":"shutterstock_264060908-403x315.jpg","width":403,"height":315,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-403x315.jpg"},"uwi-featured-content-video":{"file":"shutterstock_264060908-289x159.jpg","width":289,"height":159,"mime-type":"image\/jpeg","source_url":"https:\/\/kinsta.unitedwithisrael.org\/wp-content\/uploads\/2016\/02\/shutterstock_264060908-289x159.jpg"},"uwi-content-loop-video":{"file":"shutterstock_264060908-189x189.jpg","width":189,"height":189,"mime-type":"image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